학술논문
Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes
Document Type
Article
Author
Le Grand, Quentin; Satizabal, Claudia L.; Sargurupremraj, Muralidharan; Mishra, Aniket; Soumaré, Aicha; Laurent, Alexandre; Crivello, Fabrice; Tsuchida, Ami; Shin, Jean; Macalli, Mélissa; Singh, Baljeet; Beiser, Alexa S.; DeCarli, Charles; Fletcher, Evan; Paus, Tomas; Lathrop, Mark; Adams, Hieab H.H.; Bis, Joshua C.; Seshadri, Sudha; Tzourio, Christophe; Mazoyer, Bernard; Debette, Stéphanie
Source
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; 20210101, Issue: Preprints
Subject
Language
ISSN
24519022
Abstract
Subcortical brain structures play a key role in pathological processes of age-related neurodegenerative disorders. Mounting evidence also suggests that early-life factors may have an impact on the development of common late-life neurological diseases, including genetic factors that can influence both brain maturation and neurodegeneration.