학술논문
Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial
Document Type
Article
Author
Han, Joseph K; Bachert, Claus; Fokkens, Wytske; Desrosiers, Martin; Wagenmann, Martin; Lee, Stella E; Smith, Steven G; Martin, Neil; Mayer, Bhabita; Yancey, Steven W; Sousa, Ana R; Chan, Robert; Hopkins, Claire; Ahlström Emanuelsson, Cecilia; Ardusso, Ledit; Armstrong, Michael; Bardin, Philip; Barnes, Sara; Bergna, Miguel; Betz, Christian; Beule, Achim; Blotter, James; Bronescu, Valeriu; Brown, Matthew; Carrie, Sean; Chaker, Adam; Cho, Hyung-Ju; Corriveau, Marie-Noëlle; Courville, Timothy; Cuevas, Mandy; Damask, Cecelia; DeConde, Adam; Del Carpio, Jaime; De Salvo, María; Dhong, Hun-Jong; Durham, Stephen; Edin, Anton; Ehmer Jr, Dale; Elías, Pedro; Fatakia, Adil; Franzese, Christine; Gane, Simon; García, Gabriel; Gillman, Andrew; Groeger, Moritz; Harvey, Richard; Hellgren, Johan; Higgins, Thomas; Hobson, Jonathan; Jangard, Mattias; Janjua, Arif; Kara, Naveed; Karpischenko, Sergey; Kerwin, Edward; Khanova, Fatimat; Kilty, Shaun; Kim, Chang-Hoon; Kim, Seontae; Klimek, Ludger; LaForce, Craig; Leong, Samuel; Marple, Bradley; Mårtensson, Anders; Maspero, Jorge; Massey, Neil; Matz, Jonathan; McDuffie, Chad; Mella, Corina; Miller, Steven; Mirzabekyan, Ekaterina; Moss, Jonathan; Mumneh, Nayla; Nathan, Robert; Neagos, Adriana; Olze, Heidi; Ovchinnikov, Andrey; Ow, Randall; Polyakov, Dmitriy; Radeanu, Doinel; Rhee, Chae-Seo; Rojas, Ramón; Rosenbloom, Jeffrey; Ryazantsev, Sergei; Sader, Chady; Saez Scherbovsky, Pablo; Scadding, Guy; Schlosser, Rodney; Shah-Patel, Heena; Shealy, Ronald; Siddiqi, Ayesha; Silvers, Stacey; Singh, Narinder; Sommer, Doron; Soong, Weily; Sowerby, Leigh; Spafford, Peter; Stefan, Catalin; Sterling, Richard; Svistushkin, Valeriy; Talreja, Neetu; Tarasova, Galina; Tarpay, Martha; Tolcachier, Alberto; Toll, Karin Toll; van Schaik, Carolina; Webb, Luke; Wedner, H James; Wehbe, Luis; Whan Kim, Soo; Wollenberg, Barbara; Wright, Simon; Yakusevich, Vladimir; Yañez, Anahí; Yarin, Yury; Yen, David; Yeol Kim, Hyo
Source
The Lancet Respiratory Medicine; October 2021, Vol. 9 Issue: 10 p1141-1153, 13p
Subject
Language
ISSN
22132600; 22132619
Abstract
Chronic rhinosinusitis with nasal polyps affects approximately 2–4% of the general population, and long-term use of systemic corticosteroids is associated with adverse effects. The aim of this study was to assess the efficacy and safety of mepolizumab in adults with recurrent, refractory severe bilateral chronic rhinosinusitis with nasal polyps.