학술논문
Perioperative pharmacokinetic-guided factor VIII concentrate dosing in haemophilia (OPTI-CLOT trial): an open-label, multicentre, randomised, controlled trial
Document Type
Article
Author
van Moort, Iris; Preijers, Tim; Bukkems, Laura H; Hazendonk, Hendrika C A M; van der Bom, Johanna G; Laros-van Gorkom, Britta A P; Beckers, Erik A M; Nieuwenhuizen, Laurens; van der Meer, Felix J M; Ypma, Paula; Coppens, Michiel; Fijnvandraat, Karin; Schutgens, Roger E G; Meijer, Karina; Leebeek, Frank W G; Mathôt, Ron A A; Cnossen, Marjon H; Cnossen, Marjon H.; Leebeek, Frank W.G.; Mathôt, Ron A.A.; Fijnvandraat, Karin; Coppens, Michiel; Meijer, Karina; Kruip, Marieke J.H.A.; Polinder, Suzanne; Lock, Janske; Hazendonk, Hendrika C.A.M.; Van Moort, Iris; Heijdra, Jessica M.; Goedhart, Marie C.H.J.; Al Arashi, Wala; Preijers, Tim; De Jager, Nico C.B.; Bukkems, Laura H.; Cloesmeijer, Michael E.; Janssen, Alexander; Tamminga, Rienk Y.J.; Brons, Paul; Schols, Saskia E.M.; Eikenboom, Jeroen C.J.; Van der Meer, Felix J.M.; Schutgens, Roger E.G.; Fischer, Kathelijne; Van Galen, Karin P.M.; Beckers, Erik E.A.M.; Heubel-Moenen, Floor C.J.I.; Nieuwenhuizen, Laurens; Ypma, Paula; Driessens, Mariëtte H.E.; Van Vliet, Ineke; Collins, Peter W.; Liesner, Ri; Chowdary, Pratima; Millar, Carolyn M.; Hart, Dan; Keeling, David
Source
The Lancet Haematology; July 2021, Vol. 8 Issue: 7 pe492-e502, 11p
Subject
Language
ISSN
23523026
Abstract
Dosing of replacement therapy with factor VIII concentrate in patients with haemophilia A in the perioperative setting is challenging. Underdosing and overdosing of factor VIII concentrate should be avoided to minimise risk of perioperative bleeding and treatment costs. We hypothesised that dosing of factor VIII concentrate on the basis of a patient's pharmacokinetic profile instead of bodyweight, which is standard treatment, would reduce factor VIII consumption and improve the accuracy of attained factor VIII levels.