학술논문
Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial
Document Type
Article
Author
Lescure, François-Xavier; Honda, Hitoshi; Fowler, Robert A; Lazar, Jennifer Sloane; Shi, Genming; Wung, Peter; Patel, Naimish; Hagino, Owen; Bazzalo, Ignacio J.; Casas, Marcelo M.; Nuñez, Sebastián A.; Pere, Yael; Ibarrola, Carlos M.; Solis Aramayo, Marco A.; Cuesta, Maria C.; Duarte, Andrea E.; Gutierrez Fernandez, Pablo M.; Iannantuono, Maria A.; Miyazaki, Erica A.; Silvio, Javier P.; Scublinsky, Dario G.; Bales, Alessandra; Catarino, Daniela; Fiss, Elie; Mohrbacher, Sara; Sato, Victor; Baylao, Antonio; Cavalcante, Adilson; Correa, Francini; de Andrade, Celso A.; Furtado, Juvencio; Ribeiro Filho, Nelson; Telles, Valéria; Trevelin, Leopoldo T.; Vipich, Ricardo; Boldo, Rodrigo; Borges, Paula; Lobo, Suzana; Luckemeyer, Graziela; Machado, Luana; Alves, Maysa B.; Iglessias, Ana C.; Lago, Marianna M.; Santos, Daniel W.; Chapdelaine, Hugo; Falcone, Emilia L.; Jamal, Rahima; Luong, Me-Linh; Durand, Madeleine; Doucet, Stephane; Carrier, François-Martin; Coburn, Bryan A.; Del Sorbo, Lorenzo; Walmsley, Sharon L.; Belga, Sara; Chen, Luke Y.; Mah, Allison D.; Steiner, Theodore; Wright, Alissa J.; Hajek, J.; Adhikari, Neill; Fowler, Robert A.; Daneman, Nick; Khwaja, Kosar A.; Shahin, Jason; Gonzalez, Carolina; Silva, Rafael; Lindh, Marcelo; Maluenda, Gabriel; Fernandez, Patricia; Oyonarte, Maite; Lasso, Martin; Boyer, Alexandre; Bronnimann, Didier; Bui, Hoang-Nam; Cazanave, Charles; Chaussade, Helene; Desclaux, Arnaud; Ducours, Mailys; Duvignaud, Alexandre; Malvy, Denis; Martin, Lisa; Neau, Didier; Nguyen, Duc; Pistone, Thierry; Soubrane-Wirth, Gaetane; Leitao, Julie; Allavena, Clotilde; Biron, Charlotte; Bouchez, Sabelline; Gaborit, Benjamin; Gregoire, Antoine; Le Turnier, Paul; Lecompte, Anne-Sophie; Lecomte, Raphael; Lefebvre, Maeva; Raffi, Francois; Boutoille, David; Morineau, Pascale H.; Guéry, Romain; Chatelus, Emmanuel; Dumoussaud, Nathalie; Felten, Renaud; Luca, Florina; Goichot, Bernard; Schneider, Francis; Taquet, Marie-Caroline; Groh, Matthieu; Roumier, Mathilde; Neuville, Mathilde; Bachelard, Antoine; Isernia, Valentina; Lescure, F-Xavier; Phung, Bao-Chau; Rachline, Anne; Sautereau, Aurelie; Vallois, Dorothee; Bleher, Yves; Boucher, Delphine; Coudon, Clémentine; Esnault, Jean; Guimard, Thomas; Leautez-Nainville, Sophie; Merrien, Dominique; Morrier, Marine; Motte-Vincent, Pauline; Gabeff, Romain; Leclerc, Hélène; Cozic, Céline; Decours, Romain; Février, Ronan; Colin, Gwenhael; Abgrall, Sophie; Vignes, Dorothee; Sterpu, Raluca; Kuellmar, Mira; Meersch-Dini, Melanie; Weiss, Raphael; Zarbock, Alexander; Antony, Christiane; Berger, Marc; Brenner, Thorsten; Taube, Christian; Herbstreit, Frank; Dolff, Sebastian; Konik, Margarethe; Schmidt, Karsten; Zettler, Markus; Witzke, Oliver; Boell, Boris; Garcia Borrega, Jorge; Koehler, Philipp; Zander, Thomas; Dusse, Fabian; Al-Sawaf, Othman; Köhler, Philipp; Eichenauer, Dennis; Kochanek, Matthias; Shimabukuro-Vornhagen, Alexander; Mellinghoff, Sibylle; Claßen, Annika; Heger, Jan-Michel; Meyer-Schwickerath, Charlotte; Liedgens, Paul; Heindel, Katrin; Belkin, Ana; Biber, Asaf; Gilboa, Mayan; Levy, Itzchak; Litachevsky, Vladislav; Rahav, Galia; Finesod Wiedner, Anat; Zilberman-Daniels, Tal; Oster, Yonatan; Strahilevitz, Jacob; Sviri, Sigal; Baldissera, Elena M.; Campochiaro, Corrado; Cavalli, Giulio; Dagna, Lorenzo; De Luca, Giacomo; Della Torre, Emanuel; Tomelleri, Alessandro; Bernasconi De Luca, Davide; Capetti, Amedeo F.; Coen, Massimo; Cossu, Maria V.; Galli, Massimo; Giacomelli, Andrea; Gubertini, Guido A.; Rusconi, Stefano; Burastero, Giulia J.; Digaetano, Margherita; Guaraldi, Giovanni; Meschiari, Marianna; Mussini, Cristina; Puzzolante, Cinzia; Volpi, Sara; Aiello, Marina; Ariani, Alarico; Chetta, Alfredo A.; Frizzelli, Annalisa; Ticinesi, Andrea; Tuttolomondo, Domenico; Aliberti, Stefano; Blasi, Francesco B.; Di Pasquale, Marta F.; Misuraca, Sofia; Pilocane, Tommaso; Simonetta, Edoardo; Aghelmo, Alessio M.; Angelini, Claudio; Brunetta, Enrico; Canonica, Giorgio W.; Ciccarelli, Michele; Dal Farra, Sara; De Santis, Maria; Ferri, Sebastian; Folci, Marco; Guidelli, Giacomo M.; Heffler, Enrico M.; Loiacono, Ferdinando; Malipiero, Giacomo; Paoletti, Giovanni; Pedale, Rosa; Puggioni, Francesca A.; Racca, Francesca; Zumbo, Aurora; Satou, Morihiko; Honda, Hitoshi; Lisun, Tatyana; Protsenko, Denis; Rubtsov, Nikolay; Beloglazova, Irina; Fomina, Daria; Lysenko, Mariana; Serdotetskova, Sofia; Firstov, Vitali; Gordeev, Ivan; Kokorin, Ilia; Komissarova, Ksenia; Lapochkina, Nina; Luchinkina, Elena; Malimon, Valentin; Mamedguseyinova, Sevinch; Polubatonova, Ksenia; Suvorova, Natalia; Arribas, Jose; Borobia Perez, Alberto M.; de la Calle Prieto, Fernando; Figueira, Juan Carlos; Motejano Sanchez, Rocio; Mora-Rillo, Marta; Prados Sanchez, Concepcion; Queiruga Parada, Javier; Fernandez Arnalich, Francisco; Guerro Barrientos, Maria; Bendala Estrada, Alejandro; Caballero Marcos, Aranzazu; Garcia Leoni, Maria E.; García-Martínez, Rita; Collado, Ana María; Munoz Garcia, Patricia; Torres do Rego, Ana; Villalba García, María V.; Burrillo, Almudena; Valerio Minero, Maricela; Gijon Vidaurreta, Paloma; Infante Herrero, Sonsoles; Velilla, Elena; Machado, Marina; Olmedo, Maria; Pinilla, Blanca; Almirante Gragera, Benito; Cañas Ruano, Maria de la Esperanza; Contreras Medina, Sofia; Cortés Herrera, Alejandro; Falcó Ferrer, Vicenç; Ferrer Roca, Ricard; Nuvials Casals, Xavier; Ribera Pascuet, Esteve; Suanzes Diez, Paula; Rebollo Castro, Pedro; Garcia Alcaide, Felipe; Soriano, Alejandro; Oliver Caldes, Aina; González Cordón, Ana; Cardozo, Celia; De la Mora Cañizo, Lorena; Pena López, Romina; Chamorro, Sandra; Crespillo-Andujar, Clara; Escudero Sanchez, Rosa; Fortún-Abete, Jesús; Monge-Maillo, Begoña; Moreno Zamora, Ana; Norman, Francesca; Sanchez Conde, Matilde; Serrano Villar, Sergio; Vizcarra, Pilar
Source
The Lancet Respiratory Medicine; May 2021, Vol. 9 Issue: 5 p522-532, 11p
Subject
Language
ISSN
22132600; 22132619
Abstract
Elevated proinflammatory cytokines are associated with greater COVID-19 severity. We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical (requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19.