학술논문
Palladium-Catalyzed Dual Coupling Reaction of 2-Iodobiphenyls with o-Bromoanilines through C–H Activation: An Approach for the Synthesis of Tribenzo[b,d,f]azepines
Document Type
Article
Author
Source
Organic Letters; February 2021, Vol. 23 Issue: 4 p1239-1242, 4p
Subject
Language
ISSN
15237060; 15237052
Abstract
A novel and straightforward approach for the synthesis of tribenzo[b,d,f]azepines starting from 2-iodobiphenyls and 2-bromoanilines has been developed. A wide range of tribenzo[b,d,f]azepines were obtained in good to excellent yields via a cascade intermolecular palladium-catalyzed C–H activation/dual coupling reaction. C,C-palladacycles, which are generated by C–H activation of 2-iodobiphenyls, should be the reaction intermediates.