학술논문
Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study
Document Type
Article
Author
Bach, Simon P; Gilbert, Alexandra; Brock, Kristian; Korsgen, Stephan; Geh, Ian; Hill, James; Gill, Talvinder; Hainsworth, Paul; Tutton, Matthew G; Khan, Jim; Robinson, Jonathan; Steward, Mark; Cunningham, Christopher; Levy, Bruce; Beveridge, Alan; Handley, Kelly; Kaur, Manjinder; Marchevsky, Natalie; Magill, Laura; Russell, Ann; Quirke, Philip; West, Nicholas P; Sebag-Montefiore, David; Brown, Gina; Antonio, Peter; Vince, Alex; Hilken, Nick; Sidile, Chakanaka; Wilcockson, Adrian; Peto, Richard; Crosby, Tom; Moran, Brendan; Olliff, Julie; Ashok, Katti; Slawik, Simone; Smethurst, Andrew; Sripadam, Rajaram; Tagore, Veena; Terlizzo, Monica; Philip, Bearn; Davies, Robert; Dodd, Susan; Essapen, Sharadah; Nisar, Pasha; Stewart, Alexandra; Trickett, Jonathan; Ashish, Bansal; Billings, Peter; Chandran, Palanichamy; Corr, Conor; Favill, Edward; Gollins, Simon; Marsh, Peter; Maw, Andrew; Neupane, Rakha; Rajagopal, Ramesh; Cooper, Rachel; Griffith, John; Hatfield, Paul; Lowe, Andy; Ostrowski, Julian; Robinson, Jonathan; Simpson, Rhian; Adams, Richard; Bleehen, Robert; Davies, Michael; Morgan, Meleri; Boone, Darren; Lacey, Nicola; Seddon, Ian; Sizer, Bruce; Stunell, Helen; Wu, Shaobin; Hadaki, Maher; Blunt, Dominic; Cleator, Susan; Darzi, Ara; Goldin, Robert; Ziprin, Paul; Dobson, Mike; Pitt, Mark; Susnerwala, Shabbir; Williamson, Deborah; Howarth, Georgina; Lee, Stephen; Wright, Paul; Hoare, Tim; Horgan, Alan; McDonald, Fiona; Needham, Stephanie; Scott, John; Simmons, Timothy; Biswas, Debashis; Hernon, James; Kapur, Gaurav; Kapur, Sandeep; Sington, James; Speakman, Christopher; Stebbings, William; Williams, Stuart; Adusumalli, Madhavi; Agarwal, Anil; Borowski, David; Garg, Dharmendra; Gill, Talvinder; Hegab, Mohammed; Hobday, Catherine; Rao, Veena; Shrimankar, Jyotsna; Tabaqchali, Mohamed; Wilson, David; Jones, Oliver; Mortensen, Neil; Slater, Andrew; Szuts, Aron; Wang, Lai; Warren, Bryan; Weaver, Andrew; Ahmad, Mukhtar; Alexander, Julian; Flubacher, Maxine; Tarver, David; Baluch, Suhail; Beable, Richard; Cowlishaw, David; Higginson, Antony; Vogiatzis, Prokopios; Cruickshank, Neil; Joy, Howard; Peake, David; Zanetto, Ulises; Saunders, Mark; Sun-Myint, Arthur; Sripadam, Rajaram; Cooper, Rachel; Hatfield, Paul; Teo, Mark; Allan, Arthur; Geh, Ian; Glaholm, John; Goldstein, Mark; Hejmadi, Rahul; Langman, Gerald; Morton, Dion; Nelson, Cyril; Tattersall, Deborah; Falk, Stephen; Longman, Robert; Roach, Huw; Shabbir, Jamshed; Shelley-Fraser, Golda; Thomas, Michael; Cripps, Neil; Haba, Yasser; Harris, Guy; Hookway, Max; Simson, Jay; Skull, Angela; Umar, Tijani
Source
The Lancet Gastroenterology & Hepatology; February 2021, Vol. 6 Issue: 2 p92-105, 14p
Subject
Language
ISSN
24681253
Abstract
Radical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective total mesorectal excision could reduce the adverse effects of treatment without substantially compromising oncological outcomes. We investigated the feasibility of recruiting patients to a randomised trial comparing an organ-preserving strategy with total mesorectal excision.