학술논문
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
Document Type
Article
Author
Thomalla, Götz; Boutitie, Florent; Ma, Henry; Koga, Masatoshi; Ringleb, Peter; Schwamm, Lee H; Wu, Ona; Bendszus, Martin; Bladin, Christopher F; Campbell, Bruce C V; Cheng, Bastian; Churilov, Leonid; Ebinger, Martin; Endres, Matthias; Fiebach, Jochen B; Fukuda-Doi, Mayumi; Inoue, Manabu; Kleinig, Timothy J; Latour, Lawrence L; Lemmens, Robin; Levi, Christopher R; Leys, Didier; Miwa, Kaori; Molina, Carlos A; Muir, Keith W; Nighoghossian, Norbert; Parsons, Mark W; Pedraza, Salvador; Schellinger, Peter D; Schwab, Stefan; Simonsen, Claus Z; Song, Shlee S; Thijs, Vincent; Toni, Danilo; Hsu, Chung Y; Wahlgren, Nils; Yamamoto, Haruko; Yassi, Nawaf; Yoshimura, Sohei; Warach, Steven; Hacke, Werner; Toyoda, Kazunori; Donnan, Geoffrey A; Davis, Stephen M; Gerloff, Christian; Acosta, Boris Raul; Aegidius, Karen; Albiker, Christian; Alegiani, Anna; Almendrote, Miriam; Alonso, Angelika; Althaus, Katharina; Amarenco, Pierre; Amiri, Hemasse; Anders, Bettina; Aniculaesei, Adriana; Appleton, Jason; Arenillas, Juan; Back, Christina; Bähr, Christian; Bardutzky, Jürgen; Baronnet-Chauvet, Flore; Bathe-Peters, Rouven; Bayer-Karpinska, Anna; Becerra, Juan L.; Beck, Christoph; Belchí Guillamon, Olga; Benoit, Amandine; Berhoune, Nadia; Bindila, Daniela; Birchenall, Julia; Blanc-Lasserre, Karine; Blanco Gonzales, Miguel; Bobinger, Tobias; Bodechtel, Ulf; Bodiguel, Eric; Bojaryn, Urszula; Bonnet, Louise; Bouamra, Benjamin; Bourgeois, Paul; Boutitie, Florent; Breuer, Lorenz; Breynaert, Ludovic; Broughton, David; Brouns, Raf; Brugirard, Sébastian; Bruneel, Bart; Buggle, Florian; Cakmak, Serkan; Calleja, Ana; Calvet, David; Carrera, David; Chen, Hsin-Chieh; Cheng, Bastian; Cheripelli, Bharath; Cho, Tae-Hee; Choe, Chi-un; Choy, Lillian; Christensen, Hanne; Ciatipis, Mareva; Cloud, Geoffrey; Cogez, Julien; Cortijo, Elisa; Crozier, Sophie; Damgaard, Dorte; Dani, Krishna; De Coene, Beatrijs; De Hollander, Isabel; De Keyser, Jacques; De Klippel, Nina; De Maeseneire, Charlotte; De Smedt, Ann; del Mar Castellanos Rodrigo, Maria; Deltour, Sandrine; Demeestere, Jelle; Derex, Laurent; Desfontaines, Philippe; Dittrich, Ralf; Dixit, Anand; Dobbels, Laurens; Domigo, Valérie; Dorado, Laura; Druart, Charlotte; Dupont, Kristina Hougaard; Dusart, Anne; Dziewas, Rainer; Ebinger, Martin; Ebner, Matthias; Edjali-Goujon, Myriam; Eisele, Philipp; El Tawil, Salwa; Elhfnawy, Ahmed; Endres, Matthias; Etexberria, Ana; Evans, Nicholas; Fandler, Simon; Fazekas, Franz; Felix, Sandra; Fiebach, Jochen B.; Fiehler, Jens; Filipov, Alexandra; Filipski, Katharina; Fleischmann, Robert; Foerch, Christian; Ford, Ian; Gaenslen, Alexandra; Galinovic, Ivana; Gancedo, Elena Meseguer; Ganeshan, Ramanan; García Esperón, Carlos; Garrido, Alicia; Gattringer, Thomas; Geraghty, Olivia; Geran, Rohat; Gerloff, Christian; Gerner, Stefan; Godon-Hardy, Sylvie; Göhler, Jos; Golsari, Amir; Gomis, Meritxell; Gorriz, David; Gramse, Verena; Grau, Laia; Griebe, Martin; Guerrero, Cristina; Guerzoglu, Damla; Guettier, Sophie; Guiraud, Vincent; Gumbinger, Christoph; Gunreben, Ignaz; Haertig, Florian; Hametner, Christian; Hanseeuw, Bernard; Hansen, Andreas; Hansen, Jakob; Harbo, Thomas; Harloff, Andreas; Harmel, Peter; Häusler, Karl Georg; Heinen, Florian; Held, Valentin; Hellwig, Simon; Hemelsoet, Dimitri; Hennerici, Michael; Herm, Juliane; Hermans, Sylvia; Hernández, María; Hervas Vicente, Jose; Hjort, Niels; Hobeanu, Cristina; Hobohm, Carsten; Höfner, Elmar; Hohenbichler, Katharina; Hommel, Marc; Hoppe, Julia; Hornberger, Eva; Hoyer, Carolin; Huang, Xuya; Ipsen, Nils; Isern, Irina; Ispierto, Lourdes; Iversen, Helle; Jeppesen, Lise; Jimenez, Marta; Jungehülsing, Jan; Jüttler, Eric; Kalladka, Dheeraj; Kallmünzer, Bernd; Kar, Arindam; Kellert, Lars; Kemmling, André; Kessler, Tobias; Khan, Usman; Klein, Matthias; Kleinschnitz, Christoph; Klockziem, Matti; Knops, Michael; Koehler, Luzie; Koehrmann, Martin; Kohlfürst, Heinz; Kollmar, Rainer; Kraft, Peter; Krause, Thomas; Kristensen, Bo; Kröber, Jan M.; Kurka, Natalia; Ladoux, Alexandre; Laloux, Patrice; Lamy, Catherine; Landrault, Emmanuelle; Lauer, Arne; Lebely, Claire; Leempoel, Jonathan; Lees, Kennedy; Leger, Anne; Legrand, Laurence; Lemmens, Robin; Li, Lin; Löbbe, Anna-Mareike; London, Frederic; Lopez-cancio, Elena; Lorenz, Matthias; Louw, Stephen; Lovelock, Caroline; Lozano Sánchez, Manuel; Lucente, Giuseppe; Lückl, Janos; Luna, Alain; Macha, Kosmas; Machet, Alexandre; Mackenrodt, Daniel; Madzar, Dominik; Majoie, Charles; Männer, Anika; Maqueda, Vicky; Marstrand, Jacob; Martinez, Alicia; Marzina, Annika; Mechthouff, Laura; Meden, Per; Meersman, Guy; Meier, Julia; Mellerio, Charles; Menn, Oliver; Meyer, Nadja; Michalski, Dominik; Michels, Peter; Michelsen, Lene; Millán Torne, Monica; Minnerup, Jens; Modrau, Boris; Moeller, Sebastian; Møller, Anette; Morel, Nathalie; Moreton, Fiona; Morin, Ludovic; Moulin, Thierry; Moynihan, Barry; Mueller, Anne K.; Muir, Keith W.; Mulero, Patricia; Mundiyanapurath, Sibu; Mutzenbach, Johannes; Nagel, Simon; Naggara, Oliver; Nallasivan, Arumugam; Navalpotro, Irene; Nave, Alexander H.; Nederkoorn, Paul; Neeb, Lars; Neugebauer, Hermann; Neumann-Haefelin, Tobias; Nighoghossian, Norbert; Oberndorfer, Stefan; Opherk, Christian; Oppel, Lorenz; Oppenheim, Catherine; Orthgieß, Johannes; Ostergaard, Leif; Paindeville, Perrine; Palomeras, Ernest; Panitz, Verena; Patel, Bhavni; Peeters, Andre; Peeters, Dirk; Pellisé, Anna; Pelz, Johann; Pereira, Anthony; Pérez de la Ossa, Natalia; Perry, Richard; Petraza, Salvador; Peysson, Stéphane; Pfeilschifter, Waltraud; Pichler, Alexander; Pierskalla, Alexandra; Pledl, Hans-Werner; Poli, Sven; Pomrehn, Katrin; Poulsen, Marika; Prats, Luis; Presas, Silvia; Prohaska, Elisabeth; Puetz, Volker; Puig, Josep; Puig Alcántara, Josep; Purrucker, Jan; Quenardelle, Veronique; Ramachandran, Sankaranarayanan; Raphaelle, Soulliard; Raposo, Nicolas; Reiff, Tilman; Remmers, Michel; Renou, Pauline; Ribitsch, Martin; Richter, Hardy; Ringleb, Peter; Ritter, Martin; Ritzenthaler, Thomas; Rodier, Gilles; Rodriguez-Regent, Christine; Rodríguez-Yáñez, Manuel; Roennefarth, Maria; Roffe, Christine; Rosenbaum, Sverre; Rosso, Charlotte; Röther, Joachim; Rozanski, Michal; Ruiz de Morales, Noelia; Russo, Francesca; Rutgers, Matthieu; Sagnier, Sharmilla; Samson, Yves; Sánchez, Josep; Sauer, Tamara; Schäfer, Jan H.; Schieber, Simon; Schill, Josef; Schlak, Dennis; Schlemm, Ludwig; Schmidt, Sein; Schonewille, Wouter; Schröder, Julian; Schulz, Andreas; Schurig, Johannes; Schwarting, Sönke; Schwarz, Alexander; Schwarzbach, Christopher; Seidel, Matthias; Seiler, Alexander; Sembill, Jochen; Serena Leal, Joaquin; Shetty, Ashit; Sibon, Igor; Simonsen, Claus Z.; Singer, Oliver; Sivagnanaratham, Aravinth; Smets, Ide; Smith, Craig; Soors, Peter; Sprigg, Nikola; Spruegel, Maximilian; Stark, David; Steinert, Susanne; Stösser, Sebastian; Stuermlinger, Markus; Swinnen, Bart; Tamazyan, Ruben; Tembl, Jose; Terceno Izaga, Mikel; Thijs, Vincent; Thomalla, Götz; Touze, Emmanuel; Truelsen, Thomas; Turc, Guillaume; Turine, Gaetane; Tütüncü, Serdar; Tyrell, Pippa; Ustrell, Xavier; Vadot, Wilfried; Vallet, Anne-Evelyne; Vallet, Pauline; van den Berg, Lucie; van den Berg, Sophie; van Eendenburg, Cecile; Van Hooff, Robbert-Jan; van Sloten, Isabelle; Vanacker, Peter; Vancaester, Evelien; Vanderdonckt, Patrick; Vandermeeren, Yves; Vanhee, Frederik; Veltkamp, Roland; Vestergaard, Karsten; Viguier, Alain; Vilas, Dolores; Villringer, Kersten; Voget, Dieke; von Schrader, Jörg; von Weitzel, Paul; Warburton, Elisabeth; Weber, Claudia; Weber, Jörg; Wegscheider, Karl; Wegscheider, Mirko; Weimar, Christian; Weinstich, Karin; Weise, Christopher; Weise, Gesa; Willems, Chris; Winder, Klemens; Wittayer, Matthias; Wolf, Marc; Wolf, Martin; Wolff, Valerie; Wollboldt, Christian; Wollenweber, Frank; Wouters, Anke; Yalo, Bertrand; Yger, Marion; Younan, Nadia; Yperzeele, Laetita; Zegarac, Vesna; Zeiner, Pia; Ziemann, Ulf; Zonneveld, Thomas; Zuber, Mathieu; Akutsu, Tsugio; Aoki, Junya; Aoki, Junya; Arakawa, Shuji; Doijiri, Ryosuke; Egashira, Yusuke; Enomoto, Yukiko; Fukuda-Doi, Mayumi; Furui, Eisuke; Furuta, Konosuke; Gotoh, Seiji; Hamasaki, Toshimitsu; Hasegawa, Yasuhiro; Hirano, Teryuki; Homma, Kazunari; Ichijyo, Masahiko; Ide, Toshihiro; Igarashi, Shuichi; Iguchi, Yasuyuki; Ihara, Masafumi; Ikenouchi, Hajime; Inoue, Manabu; Inoue, Tsuyoshi; Itabashi, Ryo; Ito, Yasuhiro; Iwama, Toru; Kamiyama, Kenji; Kamiyoshi, Shoko; Kanai, Haruka; Kanematsu, Yasuhisa; Kanzawa, Takao; Kimura, Kazumi; Kitayama, Jiro; Kitazono, Takanari; Koga, Masatoshi; Kondo, Rei; Kudo, Kohsuke; Kusumi, Masayoshi; Kuwahara, Ken; Matsumoto, Shoji; Matsuoka, Hideki; Mihara, Ban; Minematsu, Kazuo; Miura, Ken; Miwa, Kaori; Morita, Naomi; Mouri, Wataru; Murata, Kayo; Nagakane, Yoshinari; Nakase, Taizen; Ohara, Hiromi; Ohara, Nobuyuki; Ohnishi, Hideyuki; Ohta, Hajime; Ohtaki, Masafumi; Ohtani, Ryo; Ohtsuki, Toshiho; Ohyama, Hideo; Okada, Takashi; Okada, Yasushi; Osaki, Masato; Sakai, Nobuyuki; Sanbongi, Yoshiki; Sasaki, Naoshi; Sasaki, Makoto; Sato, Shoichiro; Seki, Kenta; Shimizu, Wataru; Shiokawa, Yoshiaki; Sozu, Takashi; Suzuki, Junichiro; Suzuki, Rieko; Takagi, Yasushi; Takizawa, Shunya; Tanahashi, Norio; Tanaka, Eijiro; Tanaka, Ryota; Tateishi, Yohei; Terada, Tomoaki; Terasaki, Tadashi; Todo, Kenichi; Tokunaga, Azusa; Toyoda, Kazunori; Tsujino, Akira; Ueda, Toshihiro; Uesaka, Yoshikazu; Uotani, Mihoko; Urabe, Takao; Watanabe, Masao; Yagita, Yoshiki; Yakushiji, Yusuke; Yamamoto, Haruko; Yasui, Keizo; Yonehara, Toshiro; Yoshimura, Sohei; Yoshimura, Shinichi; Aarnio, K.; Alemseged, F.; Anderson, C.; Ang, T.; Archer, M.L.; Attia, J.; Bailey, P.; Balabanski, A.; Barber, A.; Barber, P.A.; Bernhardt, J.; Bivard, A.; Blacker, D.; Bladin, C.F.; Brodtmann, A.; Cadilhac, D.; Campbell, B.C.V.; Carey, L.; Celestino, S.; Chan, L.; Chang, W.H.; ChangI, A.; Chen, C.H.; Chen, C.-I.; Chen, H.F.; Chen, T.C.; Chen, W.H.; Chen, Y.Y.; Cheng, C.A.; Cheong, E.; Chiou, Y.W.; Choi, P.M.; Chu, H.J.; Chuang, C.S.; Chung, T.C.; Churilov, L.; Clissold, B.; Connelly, A.; Coote, S.; Coulton, B.; Cowley, E.; Cranefield, J.; Curtze, S.; D'Este, C.; Davis, S.M.; Day, S.; Desmond, P.M.; Dewey, H.M.; Ding, C.; Donnan, G.A.; Drew, R.; Eirola, S.; Field, D.; Frost, T.; Garcia-Esperon, C.; George, K.; Gerraty, R.; Grimley, R.; Guo, Y.C.; Hankey, G.; Harvey, J.; Ho, S.C.; Hogan, K.; Howells, D.; Hsiao, P.M.; Hsu, C.H.; Hsu, C.T.; Hsu, C.-S.; Hsu, J.P.; Hsu, Y.D.; Hsu, Y.T.; Hu, C.J.; Huang, C.C.; Huang, H.Y.; Huang, M.Y.; Huang, S.C.; Huang, W.S.; Jackson, D.; Jeng, J.S.; Jiang, S.K.; Kaauwai, L.; Kasari, O.; King, J.; Kleinig, T.J.; Koivu, M.; Kolbe, J.; Krause, M.; Kuan, C.W.; Kung, W.L.; Kyndt, C.; Lau, C.L.; Lee, A.; Lee, C.Y.; Lee, J.T.; Lee, Y.; Lee, Y.C.; Levi, C.; Levi, C.R.; Lien, L.M.; Lim, J.C.; Lin, C.C.; Lin, C.H.; Lin, C.M.; Lin, D.; Liu, C.H.; Liu, J.; Lo, Y.C.; Loh, P.S.; Low, E.; Lu, C.H.; Lu, C.J.; Lu, M.K.; Ly, J.; Ma, H.; Macaulay, L.; Macdonnell, R.; Mackey, E.; Macleod, M.; Mahadevan, J.; Maxwell, V.; McCoy, R.; McDonald, A.; McModie, S.; Meretoja, A.; Mishra, S.; Mitchell, P.J.; Miteff, F.; Moore, A.; Muller, C.; Ng, F.; Ng, F.C.; Ng, J-L.; O'Brian, W.; O'Collins, V.; Oxley, T.J.; Parsons, M.W.; Patel, S.; Peng, G.S.; Pesavento, L.; Phan, T.; Rodrigues, E.; Ross, Z.; Sabet, A.; Sallaberger, M.; Salvaris, P.; Shah, D.; Sharma, G.; Sibolt, G.; Simpson, M.; Singhal, S.; Snow, B.; Spratt, N.; Stark, R.; Sturm, J.; Sun, M.C.; Sun, Y.; Sung, P.S.; Sung, Y.F.; Suzuki, M.; Tan, M.; Tang, S.C.; Tatlisumak, T.; Thijs, V.; Tiainen, M.; Tsai, C.H.; Tsai, C.K.; Tsai, C.L.; Tsai, H.T.; Tsai, L.K.; Tseng, C.H.; Tseng, L.T.; Tsoleridis, J.; Tu, H.; Tu, H.T-H.; Vallat, W.; Virta, J.; Wang, W.C.; Wang, Y.T.; Waters, M.; Weir, L.; Wijeratne, T.; Williams, C.; Wilson, W.; Wong, A.A.; Wong, K.; Wu, T.Y.; Wu, Y.H.; Yan, B.; Yang, F.C.; Yang, Y.W.; Yassi, N.; Yeh, H.L.; Yeh, J.H.; Yeh, S.J.; Yen, C.H.; Young, D.; Ysai, C.L.; Zhang, W.W.; Zhao, H.; Zhao, L.; Althaus-Knaurer, Katharina; Bendszus, Martin; Berrouschot, Jörg; Bluhmki, Erich; Bovi, Paolo; Chatellier, Gilles; Cove, Lynda; Davis, Stephen; 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Searls, Eric; Song, Shlee S.; Starkman, Sidney; Warach, Steven; Wu, Ona; Yoo, Albert J.; Zand, Ramin
Source
The Lancet; November 2020, Vol. 396 Issue: 10262 p1574-1584, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers.