학술논문
Natural Polymorphisms in Mycobacterium tuberculosisConferring Resistance to Delamanid in Drug-Naive Patients
Document Type
Article
Author
Source
Antimicrobial Agents and Chemotherapy; August 2020, Vol. 64 Issue: 11
Subject
Language
ISSN
00664804; 10986596
Abstract
Mutations in the genes of the F420signaling pathway of Mycobacterium tuberculosiscomplex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosisstrains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes.