학술논문
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial
Document Type
Article
Author
Hill, Michael D; Goyal, Mayank; Menon, Bijoy K; Nogueira, Raul G; McTaggart, Ryan A; Demchuk, Andrew M; Poppe, Alexandre Y; Buck, Brian H; Field, Thalia S; Dowlatshahi, Dar; van Adel, Brian A; Swartz, Richard H; Shah, Ruchir A; Sauvageau, Eric; Zerna, Charlotte; Ospel, Johanna M; Joshi, Manish; Almekhlafi, Mohammed A; Ryckborst, Karla J; Lowerison, Mark W; Heard, Kathy; Garman, David; Haussen, Diogo; Cutting, Shawna M; Coutts, Shelagh B; Roy, Daniel; Rempel, Jeremy L; Rohr, Axel CR; Iancu, Daniela; Sahlas, Demetrios J; Yu, Amy Y X; Devlin, Thomas G; Hanel, Ricardo A; Puetz, Volker; Silver, Frank L; Campbell, Bruce C V; Chapot, René; Teitelbaum, Jeanne; Mandzia, Jennifer L; Kleinig, Timothy J; Turkel-Parrella, David; Heck, Donald; Kelly, Michael E; Bharatha, Aditya; Bang, Oh Young; Jadhav, Ashutosh; Gupta, Rishi; Frei, Donald F; Tarpley, Jason W; McDougall, Cameron G; Holmin, Staffan; Rha, Joung-Ho; Puri, Ajit S; Camden, Marie-Christine; Thomalla, Götz; Choe, Hana; Phillips, Stephen J; Schindler, Joseph L; Thornton, John; Nagel, Simon; Heo, Ji Hoe; Sohn, Sung-Il; Psychogios, Marios-Nikos; Budzik, Ronald F; Starkman, Sidney; Martin, Coleman O; Burns, Paul A; Murphy, Seán; Lopez, George A; English, Joey; Tymianski, Michael; Demchuk, Andrew; Barber, Philip; Smith, Eric; Bal, Simerpreet; Subramaniam, Suresh; Peters, Steven; Couillard, Phillippe; Klein, Gary; Stys, Peter; Menon, Bijoy; Coutts, Shelagh; Almekhlafi, Mohammed; Hill, Michael; Goyal, Mayank; Wong, John; Mitha, Alim; Eesa, Muneer; Morrish, William; Alqatani, Saad; Kashani, Nima; Joshi, Manish; Zerna, Charlotte; Ospel, Johanna; Venkatesan, Prasanna; Teleg, Erika; Sitaram, Amith; Graham, Brett; Van Gaal, Stephen; Moussaddy, Aimen; Chakraborty, Debabrata; Maraj, Nicholas; Loockey, Andrew; Chen, Shuo; Singh, Ravinder; Alsultan, Abdulaziz; Asuncion, Ria; Tse, Dominic; Doshi, Darshan; Volny, Ondrej; Ojha, Piyush; Wadhwa, Ankur; Marko, Martha; Singh, Nishita; Wasyliw, Sanchea; Ryckborst, Karla; Kenney, Carol; Save, Supriya; Jambula, Anitha; Newcommon, Nancy; Hull, Gavin; Blackstock, Darcy; Kiszczak, Sharon; Zimmel, Leslie; Wright, Michelle; Jahraus, Cari; Andersen, Linda; Bohn, Shelly; Paul, Joseph; Zhang, Oiao; Doram, Craig; Lowerison, Mark; Hanley, Andrea; Campbell, Lori; Ure, Ashley; Taylor, Francis; Hul, Dominic; Wiebe, Samuel; Saluzzi, Marina; Blenkin, Nicole; Frayne, Richard; Buck, Brian; Butcher, Kenneth; Shuaib, Ashfaq; Jeerakathil, Tom; Jickling, Glen; Emery, Derek; Rempel, Jeremy; Owen, Richard; Ashforth, Robert; Yeo, Tom; Kotylak, Trevor; O'Kelly, Cian; Chow, Michael; Siddiqui, Muzaffer; Saqqur, Maher; D'Souza, Atlantic; Lloret, Mar; Butt, Asif; Nomani, Ali; Kalashyan, Hayrapet; Thirunavukkarasu, Sibi; Jabs, Juline; Fairall, Paige; Piquette, Lori; Phillips, Stephen; Green, A. Laine; Gubitz, Gordon; Heidenreich, Jens; Huynh, Thien; Shankar, Jai; Maloney, William; Vandorpe, Robert; Schmidt, Matthias; Pickett, Gwynedd; Weeks, Adrienne; Jarrett, Judith; MacDonald, Debbie; Arsenault, Joanna; Kinnear, Ruth; Mandzia, Jennifer; Mayich, Michael; Boulton, Melfort; Bullrich, Maria; Fridman, Sebastian; Kiwan, Ruba; Lee, Donald; Lownie, Stephen; Khaw, Alexander; Pandey, Sachin; Sharma, Manas; Sposato, Luciano; Wade, Kevin; Beauchamp, Beth; Lambourn, Lindsay; Amato-Marziali, Belinda; Poppe, Alexandre; Roy, Daniel; Daneault, Nicole; Deschaintre, Yan; Gioia, Laura; Jacquin, Grégory; Odier, Céline; Stapf, Christian; Iancu, Daniela; Raymond, Jean; Weill, Alain; Lapierre, Marlène; Jadil, Nadia; Jolteus, Judlène; Teitelbaum, Jeanne; Angle, Mark; Hannouche, Mathew; Badawy, Mohamed; Letourneau, Justin; Cortes, Maria; Linnell, Grant; Tampieri, Donateela; Vieira, Lucy; Moussaddy, Aimen; Legault, Catherine; Durcan, Liam; Moore, Angela; Cole, Erin; Magnussen, Claire; Salmon, Kristiana; Khalil, Salma; Desloges, Isabelle; Waxman, Lindsay; Abdon, Wynne; Lai, Sonia; Dowlatshahi, Dar; Iancu, Daniela; Shamy, Michel; Stotts, Grant; Blacquiere, Dylan; Lesiuk, Howard; Quateen, Aiman; Drake, Brian; Dewar, Brian; Daham, Zeinab; Kelly, Michael; Hunter, Gary; Peeling, Lissa; Graham, Brett; Whelan, Ruth; Garner, Aaron; Urroz, Lilian; Maley, Sharleen; Silver, Frank; Casaubon, Leanne; Pikula, Aleksandra; Del Campo, Martin; Schaafsma, Joanna; Jaigobin, Cheryl; Krings, Timo; Pereira, Vitor; Agid, Ronit; Farb, Richard; Kalman, Libby; Cayley, Anne; Williams, Janice; Stewart, Tim; Misquitta, Karen; Bharatha, Aditya; Selchen, Daniel; Marotta, Thomas; Sarma, Dipanka; Montanera, Walter; Spears, Juluan; Saposnik, Gustavo; Kostyrko, Pawel; Li, Yangmei; Parra-Farina, Carmen; Bengzon Diestro, Jose Danilo; Camden, Marie-Christine; Verreault, Steve; Mackey, Ariane; Audet, Marie-Eve; Milot, Geneviève; Lavoie, Pascale; Gariépy, Jean-Luc; Collard, Karine; Haché, Annette; Van Adel, Brian; Sahlas, Demetrios; Alshanbari, Ahmed; Baldwin, Josephine; Catanese, Luciana; Chen, Bing; De Sa Boasquevisque, Danielle; Deshmukh, Aviraj; Knapman, Jordan; Lamers, Shana; Larrazabal, Ramiro; MacMillan, Susan; Mai, Lauren; Mattia, Alicia; Nayar, Sumiti; Ng, Kuan; Oczkowski, Wieslaw; Perera, Kanjana; Shawawrah, Mays; Shoamanesh, Ashkan; Sobhi, Gita; Syed, Nabeel; Taher, Noran; Vandervelde, Cheyanne; Wang Pharm, Di; Field, Thalia; Van Gaal, Stephen; Teal, Philip; Benavente, Oscar; Wilson, Laura; Mann, Sharanpal; Yip, Samuel; Murphy, Colleen; Heran, Manraj; Rohr, Axel; Settecase, Fabio; Redekop, Gary; Haw, Charles; Maclean, Genoveva; Murray, Karina; Chiu, Rosalin; Flexman, Alana; Strecha, Eilidh; Gayton, Yolanda; Yip, Judy; Swartz, Richard; Boulos, Mark; Gladstone, David; Yu, Amy; Hopyan, Julia; Khosravani, Houman; Manosalva Alzate, Herbert; Southwell, Alisia; Kamra, Maneesha; Lopes, Kaitlyn; Kapoor, Arunima; da Costa, Leodante; Yang, Victor; Dyer, Erin; Shah, Ruchir; Knowles, Brenda; Nichols, Jennifer; Patterson, Jennifer; Cope, Krista; Dickerson, Lee; Barton, Katrina; Gray, Kimberly; Massengale, Ticey; Miller, Melanie; Simpson, Cindy; Walker, Sabrina; Tennyson-Yemm, Chlin; Devlin, Thomas; Frei, Donald; Bellon, Richard; Atchie, Benjamin; Kaminsky, Ian; Wilson, Duandelyn; Schraeder, Nicolle; Arias, Eric; Kodis, Lisa; Talley, Mark; Edinger, Alex; Talley, Tiffany; Dempsey, Ita; Williams, Laurie; Williams, Scott; Kupniewski, Sonny; Fasbinder, Brad; Snead, Joanna; Choe, Hana; Mackenzie, Larami; Weisman, Davi; Kozak, Osman; Shah, Qaisar; Gzesh, Dan; Kulandaivel, Kandan; Khoury, John; Klein, Brad; Bussinger, Patricia; Griffin, Lisa; dePalmo, Ashley; Oliva, Cynthia; Jadhav, Ashutosh; Jovin, Tudor; Kenmuir, Cynthia; Jankowitz, Brian; Gross, Bradley; Rocha, Marcelo; Starr, Matthew; Brown, Merritt; Hawkes, Christine; Shah, Kavit; Tememe, Danoushka; Walker, Gregory; Patel, Pratit; Klein, Bradley; Ziayee, Habibullah; Limaye, Kaustubh; Baxendell, Lisa; Gilchrist, Vicki; Feineigle, Patricia; Toseki Haibach, Kelsea; Van Every, Cathy; Desai, Shashyat; Zulfiqar, Maryam; Gibson, Linda; Barrett, Sean; Turkel-Parrella, David; Arcot, Karthikeyan; DiCrescento, Steven; Farkas, Jeffrey; Filipowski, Gregory; Frontera, Jennifer; Joset, Danielle; Liff, Jeremy; Scher, Erica; McDougall, Cameron; Kelly, Cheryl; Patel, Akshal; Monteith, Stephen; Starkman, Sidney; Atchaneeyasakul, Kunakorn; Burgos, Adrian; Chua, Janice Anne; Gaines, Nathan; Grunberg, Ileana; Guzy, Judy; Liu, Zuolu; Maluste, Neil; Ramirez, Lucas; Sharma, Latisha; Heck, Donald; Brown, Morry; McDonald, Colin; Calderon, Mateo; Hargis, Mitch; Roels, Christina; Emmady, Prabhu; Alvi, Talat; McTaggart, Ryan; Jayaraman, Mahesh; Cutting, Shawna; Smith, Wendy; Foley, Susan; Paolucci, Gino; Has, Richard; Quinn, Katie; Fuller, Lindsey; Brierley, Rebecca; Watkins, Christina; Demir, Nicole; Lopez, George; Vargas, Alejandro; Osteraas, Nicholas; Holtz, Becky; Sauvageau, Eric; Hanel, Ricardo; Aghaebrahim, Amin; Chmayssani, Mohamad; Naval, Neeraj; Day, Jason; Dellorso, Scott; Ludwig, Benjamin; Schemmel, Derek; Ebreo, Nancy; Bell, Karen; Lewis, Lanai; Delucia, Marjorie; Nogueira, Raul; Haussen, Diogo; Frankel, Michael; Bhatt, Nirav; Bianchi, Nicolas; Anderson, Aaron; Belagaje, Samir; Liberato, Bernardo; Rangaraju, Srikant; Al-Bayati, Alhamza; Grossberg, Jonathan; Craft, Leah; Schindler, Kiva; Schaad, Erin; Schultz, Meagan; Southerly, Lorretta; Doppelheuer, Shannon; Charlton, Jacquelyn; Faggard, Jason; Barbret, Zuzana; DukSoo Han, Ethan; Walters, Robin; Dolia, Jaydevsinh; El-Jamal, Sleiman; Eby, Brendan; Saleem, Yasir; Pearl, Harrison; Patel, Kishan; Rahman, Haseeb; Butt, Reema; English, Stephen; Puri, Ajit; Howk, Mary; Singh, Jasmeet; Massari, Francesco; DeMacedo Rodrigues, Katyucia; Kuhn, Anna; English, Joey; Barazangi, Nobl; Telischak, Nick; Kim, Warren; Ross, Josh; DeVole, Nata; Redford, Jessica; Ferreira, Milena; Ponting, Katie; Shen, Helen; Bedenk, Ann; Patel, Susila; Fernandess, Julia; Ke, Michael; Spokoyny, Ilanit; Gao, Billy; Tong, David; Chen, Charlene; Wong, Christine; Choe, Jessica; Martin, Coleman; Summers, Debbie; Boutwell, Christine; Olds, Karin; Crandall, Suzanne; Eatman, John; Akhtar, Naveed; Holloway, William; Halpin, Jared; Donegan, Brett; Schindler, Joseph; Hwang, David; Gilmore, Emily; Petersen, Nils; Sheth, Kevin; Brown, Stacy; Beekman, Rachel; George, Benjamin; Kaddouh, Firas; Falcone, Guido; Wira, Charles; Matouk, Charles; Loomis, Caitlin; Amin, Hardik; Stretz, Hans Christoph; Narula, Reshma; Jasne, Adam; Sansing, Lauren; Agarwal, Tijil; Jasak, Sara; Fontaine, Briana; King, Zachary; Kuohn, Lindsey; Orgass, Hailey; Leary, Megan; Nye, Joan; Halbert, Kelsey; Nystrom, Karin; Neuschatz, Kaile; Petrucci, Dawn; Coppola, Anna; Tarpley, Jason; Joyce, Treasure; Hou, Sam; Umekubo, Mark; Nakamura, Catrice; Ovando, Renee; Zuniga, Diana; Nien, Yih Lin; Basto, Fernando Mayor; Arch, Allison; Jong, Laura; Conrad, William; Abbott, Tara; Yao, Jay; Caganap, Scott; Jordan, John; Teitelbaum, George; Darflinger, Robert; Gupta, Rishi; Bain, Marianne; Budzik, Ronald; Czerniak, Jennifer; Groezinger, Katherine; Hicks II, William; Kaskar, Omran; Katz, Brian; Loochtan, Aaron; Pema, Peter; Rai, Vivek; Vora, Nirav; Brown, Amanda; Goodman, Diane; Danenbergs, Barb; Gossett, Monica; Bang, Oh Young; Chung, Jong-Won; Jeon, Pyoung; Kim, Keon Ha; Lim, Yun Jeong; Heo, Ji Hoe; Nam, Hyo Suk; Kim, Young Dae; Park, HyungJong; Hwang, In Gun; Ha, Wooseok; Choi, Jin Kyo; Jeong, Kyungsun; Rha, Joung-Ho; Park, Hee-Kwon; Yoon, Cindy; Kim, Bo-Kyung; Sohn, Sung-Il; Kim, Chang-hyun; Yoo, Joonsang; Hong, Jeong-Ho; Park, Hyungjong; Kim, Sohyeon; Choi, Moonkyung; Bae, Hyoeun; Lee, Jun Seok; Lee, Jae-Joon; Jun, Go-Eun; Jeon, Sujeong; Campbell, Bruce; Mitchell, Peter; Yassi, Nawaf; Davis, Stephen; Donnan, Geoffrey; Parsons, Mark; Yan, Bernard; Dowling, Richard; Bush, Steven; Wu, Teddy; Shah, Darshan; Zhao, Henry; Salvaris, Patrick; Alemseged, Fana; Ng, Felix; Williams, Cameron; Balabanski, Anna; Dos Santos, Angela; Ng, Jo-Lyn; McDonald, Amy; Jackson, David; Tsoleridis, Jessica; Pesavento, Lauren; Kleinig, Timothy John; Nurs, Roy Drew; Cranefield, Jennifer; Scroop, Rebecca; Cagi, Lavenia; Harvey, Jackson; Waters, Michael; Thornton, John; Brennan, Robert; O'Hare, Alan; Power, Sarah; Williams, David; Boyle, Karl; Moynihan, Barry; Liddy, Ann-Marie; Large, Margaret; Cullen, Ailbhe; Walsh, Roisin; Martin, Emma; Lynch, Julie; McElroy, Sinéad; Murphy, Seán; Coveney, Sarah; Deegan, Caroline; Horgan, Gillian; Kelly, Peter; Laffan, Aoife; Llamas-Osorio, Yudy; Lynch, Catherine; Mac Mahon, Peter; Marnane, Michael; McCabe, John; Burns, Paul; Tauro, Suzanne; Cuddy, Sarah; Rennie, Ian; Smyth, Graham; Flynn, Peter; Wiggam, Ivan; Kerr, Enda; Gordon, Patricia; Fearon, Patricia; Roberts, Geralt; Patterson, Cathy; Adams, Karen; Wells, Brian; McFarland, Margaret; Holmin, Staffan; Moreira, Tiago; Sjöstrand, Christina; Mazya, Michael; Almqvist, Håkan; Wahlgren, Nils; Steinberg, Anna; Cooray, Charith; Eriksson, Einar; Thorén, Magnus; Keselman, Boris; Ahmed, NIaz; Holmberg, Åke; Axelsson, Maria; Berglund, Annika; Thomalla, Götz; Golsari, Amir; Hoppe, Julia; Deb-Chatterji, Milani; Cheng, Bastian; Barrow, Ewgenia; Schlemm, Eckhard; Lettow, Iris; Jensen, Märit; Otto, Dagmar; Jaramillo, Kirsten; Appelbohm, Hannes; Fiehler, Jens; Bester, Maxim; Schönfeld, Michael; Brekenfeld, Caspar; Holst, Brigitte; Wortmann, Ginette; Koch, Friederike; Puetz, Volker; Gerber, Johannes; Abramyuk, Andrij; Kaiser, Daniel; Winzer, Simon; Prakapenia, Alexandra; Pallesen, Lars-Peder; Siepmann, Timo; Barlinn, Kristian; Haase, Kathrin; Sauer, Angela; Psychogios, Marios-Nikos; Liman, Jan; Brehm, Alex; Maus, Volker; Hollstein, Nicole; Reinke, Annika; Neitz, Gustav; Schnieder, Marlena; Schwarz, Margret; Ibrahim, Allam; Müller, Julia; Meister, Stefanie; Bäumle, Berit; Chapot, René; Pilgram-Pastor, Sara; Wallocha, Marta; Stauder, Michael; Celik, Ekin; Stracke, Paul; Müller, Nicole; Weber, Ralph; Velktamp, Roland; Nagel, Simon; Ringleb, Peter Arthur; Heyse, Miriam; Amiri, Hemasse; Mundiyanapurath, Sibu; Chen, Min; Bevrle, Elisabeth; Beck, Perdita; Möhlenbruch, Markus alfred; Tymianski, Michael; Potvin, Alphonse; Harris, Cameron; Wang, Chong; Adams, Corey; Mayor, Diana; Garman, Dave; Chau, Davis; Wu, Jane; Lunn, Janet; Heard, Kathy; Bermanis, Liat; Teyes, Lucy; Constant, Marc; Galsim, Maria; Helbin, Michael; Leroux, Michelle; Felix, Nicole; Bendre, Nilima; Cuthbert, Sandra; Brokx, Steve; Zhang, Yichuan; Lingham, Trudy; Kohli, Yatika; Salter, Michael; Liebeschuetz, Joseph; Hofmann, Frieder; Constant, John; Soeder, Tom; Snoke, Kara; Bologa, Monica; Stahl, Kimberly; Graziewicz, Maria
Source
The Lancet; March 2020, Vol. 395 Issue: 10227 p878-887, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.