학술논문
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study
Document Type
Article
Author
McClung, Michael R; O'Donoghue, Michelle L; Papapoulos, Socrates E; Bone, Henry; Langdahl, Bente; Saag, Kenneth G; Reid, Ian R; Kiel, Douglas P; Cavallari, Ilaria; Bonaca, Marc P; Wiviott, Stephen D; de Villiers, Tobias; Ling, Xu; Lippuner, Kurt; Nakamura, Toshitaka; Reginster, Jean-Yves; Rodriguez-Portales, Jose Adolfo; Roux, Christian; Zanchetta, José; Zerbini, Cristiano A F; Park, Jeong-Gun; Im, KyungAh; Cange, Abby; Grip, Laura T; Heyden, Norman; DaSilva, Carolyn; Cohn, Dosinda; Massaad, Rachid; Scott, Boyd B; Verbruggen, Nadia; Gurner, Deborah; Miller, Deborah L; Blair, Micki L; Polis, Adam B; Stoch, S Aubrey; Santora, Arthur; Lombardi, Antonio; Leung, Albert T; Kaufman, Keith D; Sabatine, Marc S; Mautalén, Carlos Alfredo; Man, Zulema; Zanchetta, Jose Ruben; Magaril, Clelia Haydee; Sambrook, Philip; Reginster, Jean-Yves; Geusens, Piet; Goemaere, Stefan; Albergaria, Ben Hur; Zerbini, Cristiano Augusto de Freitas; Castro, Marise Lazaretti; Gregorio, Luiz Henrique; Stoilov, Rumen; Borissova, Anna-Maria I; Hristozov, Kiril Hristov; Temelkova, Nataliya L; Daskalova, Ivona Kirilova; Kuzmanova, Stefka Ivanova; Yaneva-Bichovska, Daniela; Batalov, Anastas Zgurov; Riedemann, Pablo; Rodriguez Portales, José Adolfo; Tang, Hai; Zhu, hanmin; Zhang, Zhenlin; Chao, Aijun; Hu, Yali; Liu, Zhiming; Lu, Juming; Qiu, Mingcai; Gao, Xin; Zhang, Shaofen; Xu, Ling; Xia, Weibo; Liao, Eryuan; Yang, Wenying; Wu, Wen; Dai, Kerong; Hu, Renming; Tang, Hai; Jaller, Juan Jose; Cabal, Francisco; Molina, José Fernando; Cure Cure, Carlos A; Yupanqui-Lozno, Hernan; Chalem, Philippe; Londono, John; Abello, Mauricio; Tobias, Edgardo D; Otero, William; Nikolic, Tatjana; Miskic, Blazenka; Stepan, Jan; Vyskocil, Vaclav; Novosad, Libor; Slesinger, Jan; Novosad, Pavel; Vlckova, Erika; Bortlik, Ladislav; Dokoupilova, Eva; Hala, Tomas; Jensen, Jens-Erik Beck; Brixen, Kim Torsten; Langdahl, Bente Lomholt; Schwarz, Peter; Eskildsen, Peter Claes; Eiken, Pia Agnete; Hermann, Anne Pernille; Gram, Jeppe; Schou, Maiken Brix; Alexandersen, Peter; Nedergaard, Bettina; Mejía, Dolores Magdalena; Estrella De Henriquez, Lourdes; Páez, Norka; Velazco, Casimiro; Valter, Ivo; Vahula, Kadri-Liina; Kull, Ingrid; Maasalu, Katre; Chapurlat, Roland; Fardellone, Patrice; Benhamou, Claude Laurent; Roux, Christian; Weryha, Georges; Herkt, Volkmar; Martz, Rene; Nischik, Ruth; Spieler, Wolfgang; Contzen, Christel; Felsenberg, Dieter; Frieling, Isolde; Frahm, Eike; Briones, Henry; Sandoval, Boris; Barrios, Patricia; García, Abraham; Avendaño, Carlos; González, Magdalena; Guerra, Jeremías; Tuna, Maria; Díaz, Olga Marina; Samayoa, Eduardo; López, Edgar; Barrera, José Raúl; Palencia, Mainor; Cifuentes, Mayra; Alvarado, Georgina; López, Miriam; Chavez, Nilmo; Haase, Franklin; Rivera, Ruddy; González, Claudio; Tan, Kathryn; Leung, Ping Chung; Mandalam, Sheshadri; Pitale, Shailesh Umakant; Bantwal, Ganapathi; Ammini, Ariachery Chinamma; Shaikh, Shehla Sajid Akhta; Kanakatte Mylariah, Prasanna Kumar; Dharmalingam, Mala; Mukhopadhyay, Satinath; Jain, Arpit; Singh, Parminder; Shetty, Naresh; Sathyanarayana, Srikanta Shamanna; Shah, Nalini; Chadha, Manoj Dharam; Bhandankar, Rajendra; Velayutham, Kumaravel; Marwah, Sudha; John, Mathew; Sahay, Rakesh Kumar; Adami, Silvano; Nuti, Ranuccio; Bianchi, Gerolamo; Brandi, Maria Luisa; Minisola, Salvatore; Fiore, Carmelo Erio; Rubinacci, Alessandro; Miyajima, Hisayuki; Yamane, Hiroo; Nakatani, Yuji; Okamoto, Sumiaki; Kuroda, Koji; Fujimori, Motoaki; Itabashi, Akira; Katayama, Kuniaki; Nakajo, Satoru; Somekawa, Yoshiaki; Ohsawa, Yoshimitsu; Tajima, Wataru; Mizuno, Katsunori; Mori, Shigeru; Kanabuchi, Takato; Hashizume, Hiroyuki; Oka, Nobuyuki; Hamada, Kazutoshi; Yamaguchi, Motoi; Hirahara, Fumiki; Atobe, Masaaki; Ohtake, Yoshiharu; Ichikawa, Shuichi; Onishi, Tomoyuki; Matsumoto, Kou; Nakamura, Tetsuro; Shirasawa, Eishi; Katayama, Ko; Takahashi, Mitsugu; Oguma, Tadanori; Matsui, Hideo; Katoh, Yoshiharu; Shigenobu, Keiichi; Onishi, Tsutomu; Shibukawa, Masato; Ikeda, Satoshi; Osaka, Kazuhiro; Kanda, Ryosuke; Inobe, Yoshito; Shigenobu, Masaharu; Hasegawa, Morimasa; Yamaji, Tetsuo; Miyazaki, Yu; Ito, Takayasu; Nakamura, Eisuke; Nagai, Shinji; Lim, Sung-Kil; Chung, Yoon-Sok; Shin, Chan-Soo; Min, Yong-Ki; Kim, Ghi Su; Yoon, Hyun Koo; Kang, Moo-Il; Yang, Kyu-Hyun; Park, Hyoung Moo; Kim, In Joo; Chung, Dong Jin; Chung, Ho Yeon; Jaundzeikare, Sandra; Andersone, Dace; Medne, Agita; Yaghi, Yasser; Alekna, Vidmantas; Kasiulevicius, Vytautas; Purtokaite - Labutiniene, Irina; Krasauskiene, Aurelija; Varanaviciene, Jurate; Basijokiene, Vida; Abraitiene, Agne; Radzeviciene, Lina; Walliser, Jesus; García Hernández, Pedro Alberto; Araujo, Maria Frida; Avila Armengol, Hilario Ernesto; De la Peña, Pilar; Tamayo, Juan; Zazueta, Beatriz; Cons, Fidencio; Gilchrist, Nigel Leslie; Reid, Ian Reginald; Leikis, Robert; Jones, Peter; Singh, Joe Gragrath Pradeep; Halse, Johan Inge; Syversen, Unni; Høivik, Hans Olav; Øfjord, Erik Snorre; Gulseth, Hans Christian; Elle, Sigbjørn; Norheim, Paal Dag; Calvo Quiroz, Armando A.; Cesar Augusto, Pastor A.; León Portocarrero, Manuel Gustavo; Vidal Neira, Luis Fernando; Chavez, Jose; Garro Barrera, Boris; Kuroiwa Sampei, Rita; Luis Fernando, Bellatín V.; Oquelis Cabredo, Rogger; Castillo, Sonia; Morales, Agustin Miguel G; Tan, Perry Pua; Leagogo, Liberato Antonio C; Wang, Edward HM; Li-Yu, Julie T; Sawicki, Andrzej Z; Stasiuk, Barbara; Kania, Grzegorz; Lorenc, Roman; Sidorowicz-Bialynicka, Anna; Szczepanski, Leszek; Franek, Edward; Filip, Rafal; Sekula, Jan; Blicharski, Tomasz; Leszczynski, Piotr; Sewerynek, Ewa; Miazgowski, Tomasz; Milewicz, Andrzej; Dabrowska, Magda; Romaszko, Jerzy; Pluskiewicz, Wojciech; Wojnowski, Lukasz; Codreanu, Catalin; Bolosiu, Horatiu; Ionescu, Ruxandra; Zosin, Ioana; Macovei, Liviu; Bojinca, Mihai; Radulescu, Florin; Pop, Simona; Sarbu, Adrian; Benevolenskaya, Lidia I; Nasonov, Evgeny L; Rozhinskaya, Lyudmila Ya; Oganov, Raphael G; Rodionova, Svetlana S; Shlyakhto, Eugeny Vladimirovich; Trofimov, Vasiliy; Zotkin, Eugeny G; Zazerskaya, Irina E; Grineva, Elena N; Ershova, Olga; Lesnyak, Olga; Ostroumova, Olga D; Malichenko, Svetlana B; Pikhlak, Eduard G; Pilyaev, Valery G; Raskina, Tatiana; Zonova, Elena V; Shirinsky, Valery S; Dimic, Aleksandar N; Cobeljic, Goran; Vujovic, Svetlana; Ellis, Graham Charlston; Lipschitz, Stanley; De Villiers, Tobias Johannes; De Weerd, Albert Jan; Vally, Tasneem; Trinder, Yvonne; Coetsee, Jacobus Ludewikus; Davis, Charles Pierre; Nayiager, Savithree; Hough, Frans Stephanus; Oelofse, Louis F; van der Walt, Eugene; Lombaard, Johannes Jurgens; Blignaut, Suzanne; Govind, Uttam; Fouche, Leon Frederik; Kruger, Dawid Stephanus; Dalmeyer, Johannes Paul; Ferreira, Mada M; Escudero-Contreras, Alejandro; Muñoz Torres, Manuel; Hawkins Carranza, Federico; Perez Castrillon, Jose Luis; García Meijide, Juan Antonio; Jodar Gimeno, Esteban; Palacios Gil-Antuñana, Santiago; de Teresa Parreno, Luis; Martín Mola, Emilio; Alvarez Sanchez, Carmen; Lippuner, Kurt; Tsai, Keh-Sung; Tu, Shih-Te; Chen, Jung-Fu; Lee, Oscar Kuang-Sheng; Hsu, Wen-Wei; Grygorieva, Natalia Viktorivna; Povoroznyuk, Vladyslav Volodymyrovych; Korzh, Mykola Oleksiiovych; Loskutov, Oleksandr Levgeniiovych; Chukov, Andriy Borysovych; Sarmiento, Rex; Thomas, Hawys; Donnachie, Hugh; Pavel-Knox, Irina; Shaw, Hilary; Hassanin, Hana; Abdulhakim, Essam Eldin Ahmed; Savani, Naren; Bachmann, Gloria A; Barrett-Connor, Elizabeth; Binkley, Neil C; Bone, Henry G; Brandon, Donald M; Checketts, Darin David; Fraser, Neil J; Watts, Nelson B; Geller, Steven A; Gimbel, Joseph S; Greenwald, Maria White; Holt, Peter A; Johnston, Cyrus Conrad; Fang, Chien; Kiel, Douglas P; Klashman, David J; Lewiecki, E. Michael; Lowenstein, Mitchell B; McClung, Michael Roy; Nattrass, Susan M; Odio, Alberto; Levengood, Julie; Romaguera, Josefina; Saag, Kenneth G; Sebai, Mohamed Bassam; Snyder, Brian; Kutner, Mark Eliot; Streja, Dan; Schwartz, Elliott P; Christiansen, Mark G
Source
The Lancet Diabetes & Endocrinology; December 2019, Vol. 7 Issue: 12 p899-911, 13p
Subject
Language
ISSN
22138587; 22138595
Abstract
Odanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone mineral density in postmenopausal women with low bone mass. We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis.