학술논문
In vitrosynergy of echinocandins with triazoles against fluconazole-resistant Candida parapsilosiscomplex isolates
Document Type
Article
Author
Source
Journal of Global Antimicrobial Resistance; June 2020, Vol. 21 Issue: 1 p331-334, 4p
Subject
Language
ISSN
22137165
Abstract
•The distribution of 15 fluconazole-resistant clinical isolates of Candida parapsilosiscomplex were as follows: Candida parapsilosis sensu stricto(n = 7), C. orthopsilosis(n = 5) and C. metapsilosis(n = 3).•In vitro combinations of fluconazole with anidulafungin (fractional inhibitory concentration index, FICI 0.07–0.37), fluconazole with micafungin (FICI 0.25–0.5), itraconazole with anidulafungin (FICI 0.15–0.37) and itraconazole with micafungin (FICI 0.09–0.37) were synergistic.•The combination of fluconazole and itraconazole with either anidulafungin or micafungin demonstrated synergistic interactions against C. parapsilosisspecies complex, especially against isolates with elevated MIC values.