학술논문
Comparative Effects of Guanfu Base A and Guanfu Base G on HERG KChannel
Document Type
Article
Author
Source
Journal of Cardiovascular Pharmacology; January 2012, Vol. 59 Issue: 1 p77-83, 7p
Subject
Language
ISSN
01602446; 15334023
Abstract
Guanfu base A (GFA) and Guanfu base G (GFG) are chemicals isolated from Aconitum coreanum. The potassium channel encoded by the human ether-a-go-go related gene(HERG) plays an important role in repolarization of the cardiac action potential. The purpose of the present study was to investigate the effects of GFA and GFG on the HERG channel and its structure–function relationship.