학술논문
Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3Acorrelation among phenotype, genotype, and mRNA expression
Document Type
Article
Author
Source
Pharmacogenetics and Genomics; November 2008, Vol. 18 Issue: 11 p989-998, 10p
Subject
Language
ISSN
17446872; 17446880
Abstract
Many antiepileptic drugs (AEDs) prevent seizures by blocking voltage-gated brain sodium channels. However, treatment is ineffective in 30 of epilepsy patients, which might, at least in part, result from polymorphisms of the sodium channel genes. We investigated the association of AED responsiveness with genetic polymorphisms and correlated any association with mRNA expression of the neuronal sodium channels.