학술논문
Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
Document Type
Article
Author
Busse, William W; Bleecker, Eugene R; FitzGerald, J Mark; Ferguson, Gary T; Barker, Peter; Sproule, Stephanie; Olsson, Richard F; Martin, Ubaldo J; Goldman, Mitchell; Yañez, Anahí; Fernández, Marcelo; Tolcachier, Alberto; Belloni, Juan; Taborda, Jorge; De Salvo, Maria; Maspero, Jorge; Victorio, Carlos; Navarta, Miguel Chirino; Grilli, Monica; Rodríguez, Pablo; Otaola, María; Cambursano, Víctor; Malamud, Patricia; Stok, Ana; Arce, German; Roza, Osiris; Scherbovsky, Fernando; Elias, Pedro; Saez, Maria Salazan; Peters, Matthew; Phillips, Martin; Upham, John; Gibson, Peter; Thien, Francis; Douglass, Jo; Thomas, Paul; Bardin, Philip; Sajkov, Dimitar; Hew, Mark; Langton, David; Pez, Andreia; Fritscher, Carlos; Hetzel, Jorge; Mattos, Waldo; Stelmach, Rafael; Antila, Martti; Fernandes, Ana Luisa; Metev, Hristo; Ivanov, Yavor; Bogdanova, Aneliya; Markova, Ana Dancheva; Peneva, Marinka; Veselinova, Rumyana; Petkova, Tatyana; Petrova, Vanushka; Shopova, Elena; Ivanova, Yuliya; Yotsova, Rumyana; Kirkova, Ginka; Petrova, Galina; Dachev, Svetoslav; Sotirova, Kostadinka; Stoyanova, Mariyana; Yakov, Oleg; Ilieva-Fartunova, Vanya; Lemiere, Catherine; Laviolette, Michel; Yang, William; FitzGerald, J Mark; Pek, Bonavuth; Killorn, William Patrick; Poirier, Claude; Chouinard, Guy; Melenka, Lyle; Leigh, Richard; Nair, Parameswaran; Dorscheid, Delbert; Martin, James; Pavie, Juana; Rosenblut, Andres; Cartagena, Claudia; Quilodran, Carlos; Muñoz, Silvia; Malkusova, Ivana; Veverka, Josef; Holub, Stanislav; Mares, Jaroslav; Kozel, Radovan; Kopecka, Daniela; Zindr, Vladimir; Cerva, Pavel; Chanez, Pascal; Bourdin, Arnaud; Devouassoux, Gilles; Taille, Camille; De Blay, Frédéric; Goupil, Francois; Leroyer, Christophe; Gourcerol, Delphine; Didi, Toufik; Didier, Alain; Garcia, Gilles; Bonniaud, Philippe; Vasram, Riazate Rossanaly; Lommatzsch, Marek; Harnest, Ulf; Linnhoff, Anneliese; Keller, Claus; Hoheisel, Gerhard; Förster, Karin; Schultz, Thomas; Schenkenberger, Isabelle; Kirschner, Joachim; Schmoller, Tibor; Zielen, Stefan; Kornmann, Marc; Beck, Ekkehard; Volgmann, Lutz; Dichmann, Rolf; Overlack, Axel; Winkler, Jörg; Mikloweit, Petra; Ballenberger, Sabine; Rolke, Mathias; Korn, Stephanie; Pabel, Helmut; Hoffmann, Martin; Feimer, Jan; Rabe, Klaus; Deckelmann, Regina; Welte, Tobias; Ohbayashi, Hiroyuki; Hozawa, Soichiro; Shimoda, Terufumi; Yoshida, Makoto; Nagakura, Toshikazu; Kamei, Tadashi; Sano, Yasuyuki; Kagami, Shinichiro; Takahashi, Hisaho; Haida, Michiko; Kimura, Goro; Nakamura, Hiroyuki; To, Yasuo; Shinkai, Masaharu; Shimokawaji, Tadasuke; Kudo, Makoto; Shijyubo, Noriharu; Tochigi, Takao; Kato, Motokazu; Tanaka, Akihiko; Gon, Yasuhiro; Sasaki, Norihisa; Ohdaira, Tetsuro; Omori, Chiharu; Takahashi, Toshiki; Takeuchi, Satomi; Nakajima, Kiyotaka; Makita, Hironi; Kaneko, Masahiro; Furuta, Kenjiro; Taniguchi, Masami; Inobe, Yoshito; Miki, Hiroshi; Nakamura, Yoichi; Miyazawa, Naoki; Yano, Shuichi; Iijima, Masayuki; Yamato, Tsuyoshi; Diaz, Javier; Matsuno, Alberto; Felix, Efrain; Guerreros, Alfredo; Daly, Alejandro; Rodriguez Chariarse, Fernando; Salazar, Danilo; Castro, Socorro; Chavez, William; Estrella, Rolando; Aquino, Teresita; Atienza, Tito; Samoro, Ronnie; Isidro, Marie Grace Dawn; Kuna, Piotr; Antczak, Adam; Bednarek, Michał; Mądra-Rogacka, Danuta; Hofman, Teresa; Jutel, Marek; Pisarczyk-Bogacka, Ewa; Kot, Agata; Mróz, Robert; Czupryńska-Borkowska, Małgorzata; Żurowska-Gębala, Małgorzata; Dyczek, Andrzej; Jasieniak-Pinis, Grażyna; Wojnowski, Piotr; Trębas-Pietraś, Ewa; Dobryniewska, Małgorzata; Stobiecki, Marcin; Tarnowska-Matusiak, Marzenna; Magner, Alina; Kolczyński, Andrzej; Kachel, Tomasz; Bartuzi, Zbigniew; Majorek-Olechowska, Bernadetta; Śliwiński, Paweł; Balicka, Violetta; Hajoł, Elżbieta; Stachera, Jacek; Rachel, Marta; Michnar, Marek; Tałałaj, Jarosław; Springer, Ewa; Napora, Piotr; Grzelewski, Tomasz; Bijata-Bronisz, Renata; Świderska, Anna; Mincewicz, Grzegorz; Sankowski, Zbigniew; Fijołek, Tomasz; Kwaśniewski, Artur; Jerzyńska, Joanna; Cygler, Jerzy; Olesiejuk, Ryszard; Von Steiner, Iwona; Machowiak, Wojciech; Filipek, Krzysztof; Piskorz, Piotr; Uhryn, Ewa; Nittner-Marszalska, Marita; Rybicka-Liszewska, Elżbieta; Bodzenta-Łukaszyk, Anna; Chełmińska, Marta; Krupa-Borek, Izabella; Skucha, Wojciech; Płoszczuk, Anna; Mihaescu, Traian; Petrui, Ioan Dorin; Savu, Angelica; Apti, Ghiulten; Toma, Claudia; Trailescu, Ana; Sokurenko, Sergei; Trofimov, Vasiliy; Leshchenko, Igor; Shaporova, Natalia; Ilyashevich, Inna; Stitsenko, Irina; Vizel, Alexander; Ilkovich, Yulia; Tikhanov, Dmitrii; Goncharova, Svetlana; Ezhov, Andrey; Ignatova, Galina; Izmozherova, Nadezhda; Berdnikova, Nadezhda; Goryachkina, Ludmila; Popova, Veronika; Bolieva, Laura; Rebrov, Andrey; Nosov, Vladimir; Magnitskaya, Olga; Nedogoda, Sergey; Abrosimov, Vladimir; Molotkov, Artem; Reshedko, Galina; Smirnov, Mikhail; Osipenko, Marina; Pavlysh, Elena; Myasoedova, Svetlana; Lenskaya, Liudmila; Chistyakov, Valery; Vishneva, Elena; Uon, Liliya; Zateyschikova, Anna; Laleko, Svetlana; Pak, Tatiana; Bruning, Axel; Naidoo, Visvakuren; Reddy, Jeevren; Van Zyl Smit, Richard; Park, Hae-Sim; Cho, Young Joo; Cho, Sang-Heon; Lee, Sang Haak; Lee, Byung Jae; Kim, Ju Sang; Cho, You Sook; Park, Choon-Sik; Kim, Mi-Kyeong; Koh, Young-Il; Kim, Joo-Hee; Lee, Sook Young; Lee, Sang Pyo; Park, Jung Won; Yoo, Kwang Ha; Yoon, Hyoungkyu; Lee, Jaechun; Hur, Gyu-Young; Lee, Soo Keol; Kim, HeeKyoo; Ramos Barbón, David; Laffond Yges, Elena; Martínez Moragón, Eva; Arias Guillen, Miguel; Saura Vinuesa, Alberto; Sánchez-Toril López, Fernando; Velasco Garrido, José Luis; García-Cosio Piqueras, Borja; Pérez de Llano, Luis; Valero Santiago, Antonio Luis; Rubio, Myriam Calle; Bjermer, Leif; Lundbäck, Bo; Gemicioglu, Bilun; Bavbek, Sevim; Ediger, Dane; Erdinc, Munevver; Hanta, Ismail; Nayci, Sibel; Arinc, Sibel; Iashyna, Liudmyla; Mostovoy, Yuriy; Ostrovskyy, Mykola; Kuryk, Lesia; Lemko, Ivan; Ospanova, Tetyana; Moskalenko, Liubov; Korzh, Oleksii; Blazhko, Viktor; Krakhmalova, Olena; Romaniuk, Liliia; Dytyatkovs'ka, Yevgeniya; Yakovenko, Oleh; Gavrysyuk, Volodymyr; Burhan, Hassan; Saralaya, Dinesh; Scott, Stephen; Morice, Alyn; Jackson-Voyzey, Ewart; Win, Thida; Nasser, Shuab; Harrison, Richard; Chaudhuri, Rekha; Nordstrom, Monica; De, Pradip; Masoli, Matthew; Mansur, Adel; Gunstone, Anthony; Niven, Robert; Harrison, Timothy; Babu, Suresh; Bhuchar, Subodh; Kureishy, Shahrukh; Zwetchkenbaum, John; Kaplan, Lawrence; Bleecker, Eugene; Reyes, Santiago; Fakih, Faisal; Heuer, Marvin; Klein, Ryan; Marcus, Michael; Hussain, Iftikhar; Tanus, Tonny; Raissy, Hengameh; Alpizar, Sady; Rodriguez, Hector; Gleich, Gerald; Bridges, Tracy; Pouzar, Joe; Steven, Gary; Matz, Jonathan; Krstevska, Shana; Ziworitin, Dama; Kaplan, Adolfo; Sublett, James; DeAngelo, James; Darter, Amy; Agaiby, John; Hagan, John; Davis, Enrique; Siri, Dareen; Mcevoy, Charlene; Dharma, Chrisette; Karimjee, Najmuddin; Kelsen, Steven; Frade, Manuel; Silverthorn, Amy; Kline, Joel; Averill, Francis; Ruiz, Jose; Robinette, Emory; Shaikh, Zeeshan; Aguilar, Carlos; Nish, William; Alvarez, German; Ismail, Younus; Parikh, Purvi; Leong, Mila; Murphy, Dennis; Garcia, Francisco; Goldsobel, Alan; Blanco, Antonio; Campbell, Edward; Perez, Guido; Chupp, Geoffrey; Bates, Toby; Perez, Vandely; Wenzel, Sally; Shenoy, Kartik; Katial, Rohit; Bernstein, David; Parikh, Neil; Sims, William; Ferguson, Gary; Pham, David; George, Anu; Beasley, Richard; Perez, Gilberto; Garver, Robert; Garcia-Portela, Miriam; Wong, Stephen; Soong, Weily; Guillot, Richard; Hudes, Golda; Arif, Ahmed; Binker, Josefa; Villareal, Manuel; Ziegner, Ulrike; Ojile, Joseph; Goswami, Sanjeev; Piniella, Carlos; Segal, Ilia; Zafra, Heidi; Lee, Mitchell; Tarpay, Martha; Panuto, John; Merchant, Rajan; Springsteen, Peter; Scialla, Timothy; Shapero, Paul; Allen, Karen; Moss, Mark; Cruz, Humberto; Rumbyrt, Jeffrey; Boyd, Amy; Nathan, Robert; Bernstein, Jonathan; Jacobs, Joshua; Ginchansky, Elliot; Johnston, Janice; Baxter, Barbara; Johnson II, Thomas; Apaliski, Stephen; Corder, Clinton; Fuentes, David; Diaz, Joseph; Ngo, Chau; Le, Lan
Source
The Lancet Respiratory Medicine; January 2019, Vol. 7 Issue: 1 p46-59, 14p
Subject
Language
ISSN
22132600; 22132619
Abstract
Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody that has been shown to safely reduce exacerbations and improve lung function for patients with asthma. We assessed the long-term safety and efficacy of benralizumab for patients with severe, uncontrolled eosinophilic asthma.