학술논문
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
Document Type
Article
Author
Hernandez, Adrian F; Green, Jennifer B; Janmohamed, Salim; D'Agostino, Ralph B; Granger, Christopher B; Jones, Nigel P; Leiter, Lawrence A; Rosenberg, Anne E; Sigmon, Kristina N; Somerville, Matthew C; Thorpe, Karl M; McMurray, John J V; Del Prato, Stefano; Del Prato, Stefano; McMurray, John J.V.; D'Agostino, Ralph B.; Granger, Christopher B.; Hernandez, Adrian F.; Janmohamed, Salim; Leiter, Lawrence A.; Califf, Robert M; Holman, Rury; DeMets, David; Riddle, Matthew; Goodman, Shaun; McGuire, Darren; Alexander, Karen; Devore, Adam; Melloni, Chiara; Patel, Chetan; Kong, David; Bloomfield, Gerald; Roe, Matthew; Tricoci, Pierluigi; Harrison, Rob; Lopes, Renato; Mathews, Robin; Mehta, Rajendra; Schuyler Jones, William; Vemulapalli, Sreekanth; Povsic, Thomas; Eapen, Zubin; Dombrowski, Keith; Kolls, Brad; Jordan, Dedrick; Ambrosy, Andrew; Greene, Stephen; Mandawat, Aditya; Shavadia, Jay; Cooper, Lauren; Sharma, Abhinav; Guimaraes, Patricia; Friedman, Daniel; Wilson, Matt; Endsley, Patricia; Gentry, Tracy; Collier, Jeannie; Perez, Kathleen; James, Kourtnei; Roush, Jennifer; Pope, Connie; Howell, Christina; Johnson, Megan; Bailey, Matt; Cole, Joanna; Akers, Teresa; Vandyne, Beth; Thomas, Betsy; Rich, Jenny; Bartone, Susan; Beaulieu, Gail; Brown, Kim; Chau, Tuan; Christian, Tamra; Coker, Rebecca; Greene, Deb; Haddock, Trevorlyn; Jenkins, Wendy; Haque, Ghazala; Marquess, Marsha; Pesarchick, Jean; Rethaford, Renee; Stone, Allegra; Al Kawas, Firas; Anderson, Michelle; Enns, Robert; Sinay, Isaac; Mathieu, Chantal; Yordanov, Victor; Hramiak, Irene; Haluzik, Martin; Galatius, Søren; Guerci, Bruno; Nauck, Michael; Migdalis, Ilias; Tan, Choon Beng Kathryn; Kocsis, Gyozo; Giaccari, Andrea; Lee, Moon Kyu; Muñoz, Ernesto German Cardona; Cornel, Jan; Birkeland, Kare; Pinto, Miguel; Tirador, Louie; Olesinska-Mader, Martyna; Shestakova, Marina; Distiller, Larry; Lopez-Sendon, Jose; Eliasson, Bjorn; Chiang, Chern-En; Srimahachota, Suphot; Mankovsky, Boris; Bethel, M Angelyn; Dungan, Kathleen; Kosiborod, Mikhail; Alvarisqueta, Andres; Baldovino, Jorge; Besada, Diego; Calella, Pedro; Cantero, Maria Cecilia; Castaño, Patricia; Chertkoff, Alejandro; Cuadrado, Jesus; De Loredo, Luis; Dominguez, Andrea; Español, Maria Vanesa; Finkelstein, Hernan; Frechtel, Gustavo; Fretes, Jose; Garrido Santos, Natalia; Gonzalez, Joaquin; Litvak, Marcos; Loureyro, Juan; Maffei, Laura; Maldonado, Natacha; Mohr Gasparini, Diego; Orio, Silvia; Perez Manghi, Federico; Rodriguez Papini, Nelson; Sala, Jorgelina; Schygiel, Pablo; Sposetti, Georgina; Ulla, Maria; Verra, Fernando; Zabalua, Silvina; Zaidman, Cesar; Crenier, Laurent; Debroye, Corinne; Duyck, Francis; Scheen, André; Van Gaal, Luc; Vercammen, Chris; Damyanova, Velichka; Dimitrov, Stefan; Kovacheva, Snezhina; Lozanov, Lachezar; Margaritov, Viktor; Mihaylova-Shumkova, Rositsa; Nikolaeva, Antoaneta; Stoyanova, Zhasmina; Akhras, Ronald; Beaudry, Yves; Bedard, Jacques; Berlingieri, Joseph; Chehayeb, Raja; Cheung, Stephen; Conway, James; Cusson, Jean; Della Siega, Anthony; Dumas, Richard; Dzongowski, Peter; Ferguson, Murdo; Gaudet, Daniel; Grondin, Francois; Gupta, Anil; Gupta, Milan; Halperin, Frank; Houle, Pierre-Alain; Jones, Michael; Kouz, Simon; Kovacs, Christopher; Landry, Daniel; Lonn, Eva; O'Mahony, William; Peterson, Sean; Reich, Dennis; Rosenbloom, Alan; St-Maurice, Francois; Tugwell, Barna; Vizel, Saul; Woo, Vincent; Brychta, Tomas; Cech, Vladimir; Dvorakova, Eva; Edelsberger, Tomas; Halciakova, Katarina; Krizova, Jarmila; Lastuvka, Jiri; Piperek, Martin; Prymkova, Vera; Raclavska, Lea; Silhova, Elena; Urbanek, Robin; Vrkoc, Jan; Andersen, Ulla; Brønnum-Schou, Jens; Hove, Jens; Jensen, Jan Skov; Kober, Lars; Kristiansen, Ole Peter; Lund, Per; Melchior, Thomas; Nyvad, Ole; Schou, Morten; Boye, Alain; Cadinot, Didier; Gouet, Didier; Henry, Patrick; Kessler, Laurence; Lalau, Jean-Daniel; Petit, Catherine; Thuan, Jean-Francois; Voinot, Christel; Vouillarmet, Julien; Axthelm, Christoph; Berger, Dirk; Bieler, Tasso; Birkenfeld, Andreas; Bott, Jochen; Busch, Klaus; Caca, Karel; Chevts, Julia; Donaubauer, Torsten; Erlinger, Rudolf; Funke, Klaus; Grosskopf, Josef; Hagenow, Andreas; Hamann, Monika; Hartard, Manfred; Heymer, Peter; Huppertz, Wolfgang; Illies, Gabriele; Jacob, Stephan; Jung, Thomas; Kahrmann, Gerd; Kast, Petra; Kellerer, Monika; Kempe, Hans-Peter; Khariouzov, Andrei; Klausmann, Gerhard; Klein, Christiane; Kleinecke-Pohl, Uwe; Kleinertz, Klaus; Koch, Thorsten; Kosch, Christine; Lorra, Babette; Luedemann, Joerg; Luttermann, Matthias; Maxeiner, Stephan; Milek, Karsten; Moelle, Andrea; Neumann, Gerhard; Nischik, Ruth; Oehrig-Pohl, Edith; Plassmann, Georg; Pohlmeier, Lars; Proepper, Felix; Regner, Stefan; Rieker, Werner; Rose, Ludger; Samer, Holger; Sauter, Joachim; Schaper, Frank; Schiffer, Clemens; Schmidt, Juergen; Scholz, Bernd-M.; Schulze, Joerg; Segner, Alexander; Seufert, Jochen; Sigal, Helena; Steindorf, Joerg; Stockhausen, Juergen; Stuebler, Petra; Taeschner, Heidrun; Tews, Dietrich; Tschoepe, Diethelm; Wilhelm, Karl; Zeller-Stefan, Helga; Avramidis, Iakovos; Bousboulas, Stavros; Bristianou, Magdalini; Dimitriadis, Georgios; Elisaf, Moses; Kotsa, Kalliopi; Melidonis, Andreas; Mitrakou, Asimina; Pagkalos, Emmanouil; Papanas, Nikolaos; Pappas, Angelos; Sampanis, Christos; Tentolouris, Nikolaos; Tsapas, Apostolos; Tzatzagou, Glykeria; Ozaki, Risa; Hajdú, Csaba; Harcsa, Eleonóra; Konyves, Laszlo; Mucsi, János; Pauker, Zsolt; Petró, Gizella; Plés, Zsolt; Revesz, Katalin; Sándor, Vangel; Vass, Viktor; Avogaro, Angelo; Boemi, Massimo; Bonadonna, Riccardo; Consoli, Agostino; De Cosmo, Salvatore; Di Bartolo, Paolo; Dotta, Francesco; Frontoni, Simona; Galetta, Marianna; Gambineri, Alessandra; Gazzaruso, Carmine; Giorgino, Francesco; Lauro, Davide; Orsi, Emanuela; Paolisso, Giuseppe; Perriello, Gabriele; Piatti, Piermarco; Pontiroli, Antonio; Ponzani, Paola; Rivellese, Angela Albarosa; Sesti, Giorgio; Tonolo, Giancarlo; Trevisan, Roberto; Ahn, Chul Woo; Baik, Sei-Hyun; Cha, Bong-Soo; Chung, Choon-Hee; Jang, Hak Chul; Kim, Chong-Jin; Kim, Hye Soon; Kim, In Joo; Lee, Eun Young; Lee, Hyoung Woo; Lee, Kwan-Woo; Moon, Keon-Woong; Namgung, June; Park, Kyong Soo; Yoo, Soon Jib; Yu, Jaemyung; Llamas, Edmundo-Alfredo Bayram; Cervantes-Escárcega, Jose-Luis; Flota-Cervera, Luis Fernando; González-González, José Gerardo; Pascoe-Gonzalez, Sara; Pelayo-Orozco, Emilia Susana; Ramirez-Diaz, Santiago-Paulino; Saldana-Mendoza, Arturo; Jerjes-Díaz, Carlos Sánchez; Torres-Colores, Jose Juan; Vidrio-Velázquez, Maricela; Villagordoa-Mesa, Juan; Beijerbacht, Hugo Peter; Groutars, Reginald G.E.J.; Hoek, Boudewijn A; Hoogslag, Pieter A.M.; Kooy, Adriaan; Kragten, Johannes A.; Lieverse, Aloysius G.; Swart, Hendrik P.; Viergever, Eric P.; Ahlqvist, Jørn; Cooper, John; Gulseth, Hanne; Guttormsen, Gaute; Wium, Cecilie; Arbañil, Hugo; Calderon, Jorge; Camacho, Luis; Espinoza, Augusto Dextre; Garrido, Elizabeth; Luna, Alejandro; Manrique, Helard; Revoredo, Frederick Massucco; Gonzales, Rolando Vargas; Rincon, Luis Zapata; Zubiate, Carlos; Ebo, Geraldine; Morales-Palomares, Ellen; Arciszewska, Malgorzata; Banach, Marek; Bijata-Bronisz, Renata; Derezinski, Tadeusz; Gadzinski, Waldemar; Gajek, Jacek; Klodawska, Katarzyna; Krzyzagorska, Ewa; Madej, Andrzej; Miekus, Pawel; Opiela, Jaroslaw; Romanczuk, Piotr; Siegel, Anna; Skokowska, Ewa; Stankiewicz, Andrzej; Stasinska, Teresa; Trznadel-Morawska, Iwona; Witek, Robert; Aksentyev, Sergey; Bondar, Irina; Demidova, Irina; Dreval, Alexander; Ershova, Olga; Galstyan, Gagik; Garganeeva, Alla; Izmozherova, Nadezhda; Karetnikova, Victoria; Kharakhulakh, Marina; Khokhlov, Aleksandr; Kobalava, Zhanna; Koshelskaya, Olga; Kosmacheva, Elena; Kostin, Vladimir; Koziolova, Natalia; Kuzin, Anatoly; Lesnov, Victor; Lysenko, Tatyana; Markov, Valentin; Mayorov, Alexander; Moiseev, Sergey; Myasoedova, Svetlana; Petunina, Nina; Rebrov, Andrey; Ruyatkina, Ludmila; Samoylova, Julia; Sazonova, Olga; Shilkina, Natalia; Sokolova, Nadezhda; Vasilevskaya, Olga; Verbovaya, Nelli; Vishneva, Elena; Vorobyev, Sergey; Vorokhobina, Natalya; Zanozina, Olga; Zhdanova, Elena; Zykova, Tatyana; Burgess, Lesley; Coetzee, Kathleen; Dawood, Saleem; Lombard, Landman; Makotoko, Ellen; Moodley, Rajendran; Oosthuysen, Wessels; Sarvan, Mohamed; Calvo Gómez, Carlos; Cano Rodríguez, Isidoro; Castro Conde, Almudena; Cequier Fillat, Angel; Cuatrecasas Cambra, Guillem; de Álvaro Moreno, Fernando; De Teresa Parreño, Luis; Delgado Lista, Javier; Domínguez Escribano, José Ramón; Durán García, Santiago; Elvira González, Javier; Fernández Rodríguez, José María; Goday Arno, Alberto; Gomez Huelgas, Ricardo; González Juanatey, José Ramón; Hernandez Mijares, Antonio; Jiménez Díaz, Víctor Alfonso; Jodar Gimeno, Esteban; Lucas Morante, Tomás; Marazuela, Monica; Martell Claros, Nieves; Mauricio Puente, Didac; Mena Ribas, Elena; Merino Torres, Juan Francisco; Mezquita Raya, Pedro; Nubiola Calonge, Andreu; Ordoñez Sánchez, Xavier; Pascual Izuel, Jose Maria; Perea Castilla, Verónica; Pérez Pérez, Antonio; Perez Soto, Isabel; Quesada Charneco, Miguel; Quesada Simón, Angustias; Redón Mas, Josep; Rego Iraeta, Antonia; Rodriguez Alvarez, Maria; Rodríguez Rodríguez, Irene; Sabán Ruiz, José; Soto González, Alfonso; Tinahones Madueno, Francisco; Trescoli Serrano, Carlos; Ulied Armiñana, Angels; Bachus, Erasmus; Berndtsson Blom, Katarina; Eliasson, Ken; Koskinen, Pekka; Larnefeldt, Hans; Lif-Tiberg, Cornelia; Linderfalk, Carina; Lund, Gustav; Lundman, Pia; Moris, Linda; Olsson, Åke; Salmonsson, Staffan; Sanmartin Berglund, Johan; Sjöberg, Folke; Söderberg, Stefan; Torstensson, Ingemar; Chen, Jung-Fu; Tien, Kai Jen; Tseng, Shih-Ting; Tu, Shih-Te; Wang, Chih-Yuan; Wang, Ji-Hung; Phrommintikul, Arintaya; Yamwong, Sukit; Jintapakorn, Woravut; Hutayanon, Pisit; Sansanayudh, Nakarin; Bazhan, Larysa; Fushtey, Ivan; Grachova, Mariya; Katerenchuk, Vitaliy; Korpachev, Vadym; Kravchun, Nonna; Larin, Oleksandr; Mykhalchyshyn, Galyna; Myshanych, Halyna; Oleksyk, Olga; Orlenko, Valeriia; Pashkovska, Nataliia; Pertseva, Nataliia; Petrosyan, Olena; Smirnov, Ivan; Vlasenko, Maryna; Zlova, Tetiana; Aye, Myint; Baksi, Arun; Balasubramani, Mathangi; Beboso, Ronnie; Blagden, Mark; Bundy, Charles; Cookson, Tobias; Copland, Allan; Emslie-Smith, Alistair; Green, Fiona; Gunstone, Anthony; Issa, Basil; Jackson-Voyzey, Ewart; Johnson, Andrew; Maclean, Malcolm; McKnight, John; Muzulu, Solomon; O'Connell, Ian; Oyesile, Babatunde; Patterson, Catherine; Pearson, Ewan; Philip, Sam; Smith, Paul; Sukumaran, Usha; Abbas, Jalal; Aggarwala, Gaurav; Akhter, Faiq; Andersen, James; Anglade, Moise; Argoud, Georges; Ariani, Mehrdad; Ashdji, Reswan; Bakhtari, Ladan; Banerjee, Subhash; Bartlett, Andrew; Baum, Howard; Bays, Harold; Beasley, Richard; Belfort de Aguiar, Renata; Benjamin, Sabrina; Bhagwat, Ravi; Bhargava, Anuj; Bode, Bruce; Bratcher, Christina; Briskin, Toby; Brockmyre, Andrew; Broughton, Raymond; Brown, Judith; Budhraja, Madhusudan; Cannon, Kevin; Carr, Jewell; Cathcart, Harold; Cavale, Arvind; Chaykin, Louis; Cheung, Deanna; Childress, Richard; Cohen, Allan; Condit, Jonathan; Cooksey, Erin; Cornett, George Mitchell; Dauber, Ira; Davila, William; De Armas, Luis; Dean, Julius; Detweiler, Robert; Diaz, Ernesto; Di Giovanna, Michael; Dor, Isaac; Drummond, Waymon; Eagerton, Donald; Earl, John; Eaton, Charles; Ellison, Howard; Farris, Neil; Fiel, Thomas; Firek, Anthony; First, Brian; Forgosh, Les; French, William; Gandy, Winston; Garcia, Ronald; Gill, Santosh; Gordon, Murray; Guice, Michael; Gummadi, Siva; Hackenyos, Jonathan; Hairston, Kristen; Hanson, Lenita; Harrison, Lindsay; Hartman, Israel; Heitner, John; Hejeebu, Srini; Hermany, Paul; Hernandez-Cassis, Carlos; Hidalgo, Horacio; Higgins, Alexander; Ibrahim, Hassan; Jacobs, Shahram; Johnson, David; Joshi, Parag; Kaster, Steven; Kellum, Daniel; Kim, Christopher; Kim, Ellen; Kirby, William; Knouse, Albert; Kulback, Steven; Kumar, Mariananda; Kuruvanka, Tulsidas; Labroo, Ajay; Lasswell, William; Lentz, John; Lenzmeier, Thomas; Lewis, David; Li, Zhaoping; Lillestol, Michael; Little, Raymond; Lorraine, Richard; McKeown-Biagas, Cecilia; McNeill, Robert; Mehta, Anand; Miller, Alan; Moran, Joseph; Morawski, Emily; Nadar, Venkatesh; O'Connor, Thomas; Odio, Alberto; Parker, Reginald; Patel, Rajesh; Phillips, Lawrence; Raad, George; Rahman, Aref; Raikhel, Marina; Raisinghani, Ajit; Rajan, Raj; Rasouli, Neda; Rauzi, Frank; Rohr, Kathryn; Roseman, Hal; Rovner, Sergio; Saba, Fadi; Sachson, Richard; Schabauer, Alex; Schneider, Ricky; Schuchard, Timothy; Sensenbrenner, John; Shlesinger, Yshay; Singh, Narendra; Sivalingam, Kanagaratnam; Stonesifer, Larry; Storey, Daniel; Suh, David; Tahir, Mohammed; Tan, Anjanette; Tan, Marilyn; Taylon, Alain; Thakkar, Maitreya; Tripathy, Devjit; Uwaifo, Gabriel; Vedere, Amarnath; Venugopal, Chandra; Vo, Anthony; Welch, Michelle; Welker, James; White, Alexander; Willis, John; Wynne, Alan; Yazdani, Shahram; Green, Jennifer B; Rosenberg, Anne; Price, Lauren; Sigmon, Kristina; Lokhngina, Yuliya; Xing, Weibing; Overton, Robert; Stewart, Murray; Stead, Janet; Lindsay, Alistair; Patel, Vickas; Ross, Jorge; Soffer, Joseph; Daga, Shruti; Sowell, Margaret; Patel, Prashant; Garvey, Louisa; Ackert, Jessica; Abraham, Sybil; Sabol, Mary Beth; Altobelli, Desma; Ha, JuYoung; Kulkarni, Mangesh; Somerville, Matthew; Noronha, Drusilla; Casson, Ed; Zang, Eddie; Sandhu, Chamandeep; Kumar, Rakesh; Chen, David; Taft, Lin; Patel, Rajivkumar; Ye, June; Shannon, Jennifer; Wilson, Tim; Babi, Charleen; Miller, Diane; Jones, Nigel P; Thorpe, Karl; Russell, Rachael; Bull, Georgina; Hereghty, Belinda; Fernandez-Salazar, Eva; Longley, Troy; Donaldson, Jill; Jarosz, Marie; Murphy, Karen; Adams, Patricia; Smith, Peter; James, Rachel; Richards, Jackie; Sedani, Sangeeta; Althouse, Denise; Watson, David; Lorimer, Jamie; Lauder, Steven; Schultheis, Ron; Womer, Terese; Wraight, Ella; Li, Wenyan; Price-Olsen, Emma; Watson, Anthony; Kelly, Aoife; McLaughlin, Patricia; Fleming, John; Schubert, Jessica; Schleiden, Debra; Harris, Tara; Prakash, Rahul; Breneman, Jody; Deshpande, Sameer; Saswadkar, Aarti; Kumari, Aditi; Shitut, Aditi; Raorane, Amruta; Karmalkar, Anisha; Mhambrey, Ankita; Bhosale, Archana; Vaphare, Ashok; Patil, Ashwini P; Khandelwal, Chaitali; Shaik, Fayaz; Nadar, Madhumitha; Karka, Mounika; Kadgaonkar, Neha; Gupta, Nikita; Aher, Nutan; Potnis, Omkar; Naicker, Pallavi; Shinde, Rakesh; Sharma, Richa; Godse, Rupali; Solanki, Sheetal; Sahu, Shruti; Dumbre, Snehal; Kumar, Somesh; Patil, Suradnya; Mandal, Trisha
Source
The Lancet; October-November 2018, Vol. 392 Issue: 10157 p1519-1529, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.