학술논문
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial
Document Type
Article
Author
Calfee, Carolyn S; Delucchi, Kevin L; Sinha, Pratik; Matthay, Michael A; Hackett, Jonathan; Shankar-Hari, Manu; McDowell, Cliona; Laffey, John G; O'Kane, Cecilia M; McAuley, Daniel F; Johnston, Andrew J; Paikray, Archana; Yates, Cat; Polgarova, Petra; Price, Esther; McInerney, Amy; Zamoscik, Katarzyna; Dempsey, Ged; Seasman, Colette; Gilfeather, Lynn; Hemmings, Noel; O'Kane, Sinead; Johnston, Paul; Pokorny, Lukas; Nutt, Chris; O'Neill, Orla; Prashast, Prashast; Smalley, Chris; Jacob, Reni; O'Rourke, James; Sultan, Syed Farjad; Schilling, Carole; Perkins, Gavin D; Melody, Teresa; Couper, Keith; Daniels, Ron; Gao, Fang; Hull, Julian; Gould, Timothy; Thomas, Matthew; Sweet, Katie; Breen, Dorothy; Neau, Emer; Peel, Willis J; Jardine, Catherine; Jefferson, Paul; Wright, Stephen E; Harris, Kayla; Thomas, Matthew; Hierons, Sarah; Laffey, John; McInerney, Veronica; Camporota, Luigi; Lei, Katie; Kaul, Sundeep; Chibvuri, Molly; Gratrix, Andrew; Bennett, Rachael; Martinson, Victoria; Sleight, Lisa; Smith, Neil; Hopkins, Philip A; Hadfield, Daniel; Casboult, Sarah; Wade-Smith, Fiona; Dawson, Julie; Mellis, Clare; Harris, Clair; Parsons, Georgina; Helyar, Sinead; Bodenham, Andrew R; Elliot, Stuart; Beardow, Zoe; Birch, Sian; Marsh, Brian; Martin, Teresa; Dhrampal, Akesh; Rosbergen, Melissa; Webb, Stephen; Bottrill, Fiona; Reschreiter, Henrik; Barcraft-Barnes, Helena; Camsooksai, Julie; Johnston, Andrew; Clarkson, Aisling; Bentley, Conor; Cooper, Lauren; Qui, Yongyan; Mitchell, Natalie; Carrera, Ronald; Whitehouse, Arlo; Danbury, Christopher M; Jacques, Nicola; Brown, Abby; Rogerson, David; Morris, Craig; Walsh, Timothy; Gillies, Mike; Price, Grant; Kefala, Kallirroi; Young, Neil; Hope, David; McCulloch, Corrienne; Antonelli, Jean; Ramsay, Pam; Everingham, Kirsty; Boardman, Louise; Dawson, Heidi; Pollock, Fiona; Thompson, Joanne; Welters, Ingeborg D; Poole, Lee; Hampshire, Peter; Hall, Alison; Williams, Karen; Walker, Anna; Youds, Laura; Hendry, Samantha; Waugh, Victoria; Patrick-Heselton, Julie; Shaw, David; Chaudry, Irfan; Baldwin, Jacqueline; Drage, Stephen; Ortiz-Ruiz de Gordoa, Laura; McAuley, Daniel; Bannon, Leona; Quinn, Vanessa; McNamee, Lia; White, Griania; Cecconi, Maurizio; Mellinghoff, Johannes; Ryan, Donal; Nichol, Alistair; Agarwal, Banwari; Meale, Paula; James, Sarah; Dhadwal, Kulwant; Martin, Daniel; Walecka, Agnieszka; Ward, Stephen; Trinder, John; Hagan, Samantha; Montgomery, Janice; Leonard, Catherine; Lemon, Elizabeth; Trinick, Tom; Buddhavarapu, Murthy; Ward, Geraldine; Bassford, Christopher; Davidson, Alan; McGuigan, Kate; Benchiheub, Anissa; Hickey, Naomi; Binning, Alexander; Henderson, Steven; Wood, J A; Burtenshaw, Andrew J; Kelly, Dawn; Martin, Terry; Thrush, Jessica; Wollaston, Julie; Graystone, Stephen; Nicol, Gavin; Sellors, Gareth
Source
The Lancet Respiratory Medicine; September 2018, Vol. 6 Issue: 9 p691-698, 8p
Subject
Language
ISSN
22132600; 22132619
Abstract
Precision medicine approaches that target patients on the basis of disease subtype have transformed treatment approaches to cancer, asthma, and other heterogeneous syndromes. Two distinct subphenotypes of acute respiratory distress syndrome (ARDS) have been identified in three US-based clinical trials, and these subphenotypes respond differently to positive end-expiratory pressure and fluid management. We aimed to investigate whether these subphenotypes exist in non-US patient populations and respond differently to pharmacotherapies.