학술논문
Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score
Document Type
Article
Author
Carbone, Marco; Nardi, Alessandra; Flack, Steve; Carpino, Guido; Varvaropoulou, Nikoletta; Gavrila, Caius; Spicer, Ann; Badrock, Jonathan; Bernuzzi, Francesca; Cardinale, Vincenzo; Ainsworth, Holly F; Heneghan, Michael A; Thorburn, Douglas; Bathgate, Andrew; Jones, Rebecca; Neuberger, James M; Battezzati, Pier Maria; Zuin, Massimo; Taylor-Robinson, Simon; Donato, Maria F; Kirby, John; Mitchell-Thain, Robert; Floreani, Annarosa; Sampaziotis, Fotios; Muratori, Luigi; Alvaro, Domenico; Marzioni, Marco; Miele, Luca; Marra, Fabio; Giannini, Edoardo; Gaudio, Eugenio; Ronca, Vincenzo; Bonato, Giulia; Cristoferi, Laura; Malinverno, Federica; Gerussi, Alessio; Stocken, Deborah D; Cordell, Heather J; Hirschfield, Gideon M; Alexander, Graeme J; Sandford, Richard N; Jones, David E; Invernizzi, Pietro; Mells, George F; Thomas, Caradog; Rahman, Meshbah; Yapp, Tom; Lye Ch'ng, Chin; Harrison, Melanie; Sturgess, Richard; Galaska, Roman; Healey, Chris; Whiteman, Jessica; Czaijkowski, Marek; Gray, Catherine; Gunasekera, Anton; Gyawli, Pranab; Premchand, Purushothaman; Mann, Steven; Elliott, Keith; Kapur, Kapil; Watson, Alan; Foster, Graham; Trembling, Paul; Subhani, Javaid; Harvey, Rory; McCorry, Roger; Adgey, Carolyn; Hobson, Lucie; Mulvaney-Jones, Caroline; Evans, Richard; Mathialahan, Thiriloganathan; Ramanaden, David; Gasem, Jaber; Van Duyvenvoorde, Greta; Shorrock, Christopher; Seward, Katie; Southern, Paul; Tibble, Jeremy; Penn, Ruth; Gorard, David; Maiden, Jane; Damant, Rose; Palegwala, Altaf; Jones, Susan; Alexander, Graeme; Mells, George; Sandford, Richard; Whiteman, Jessica; Dolwani, Sunil; Prince, Martin; Silvestre, Valeria; Foxton, Matthew; Dungca, Eleanor; Mitchison, Harriet; Wheatley, Natalie; Gooding, Ian; Doyle, Helen; Karmo, Mazn; Kent, Melanie; Saksena, Sushma; Braim, Delyth; Patel, Minesh; Lord, Susan; Ede, Roland; Paton, Alison; Austin, Andrew; Lancaster, Nicola; Sayer, Joanna; Gibbins, Andrew; Hogben, Karen; Hovell, Chris; Fisher, Neil; Carter, Martyn; Koss, Konrad; Musselwhite, Janine; Muscariu, Florin; Piotreowicz, Andrzej; McKay, Alexandra; Grimley, Charles; Neal, David; Ting Tan, Lai; Lim, Guan; Brighton, Jacqueline; Foale, Carole; Ala, Aftab; Saeed, Athar; Flahive, Kerry; Wood, Gordon; Townshend, Paula; Ford, Chris; Brown, Jonathan; Kordula, Jean; Bowles, Jane; Wilkinson, Mark; Palmer, Caroline; Ramage, John; Gordon, Harriet; Featherstone, James; Ridpath, Jo; Ngatchu, Theodore; Levi, Sass; Shaukat, Syed; Sadeghian, Joy; Shidrawi, Ray; Williams, Bronwen; Abouda, George; Jones, Sarah; Duggan, Claire; Hynes, Abigail; Narain, Mark; Rees, Ian; Salam, Imroz; Crossey, Mary; Taylor-Robinson, Simon; Brown, Ashley; MacNicol, Carolyn; Williams, Simon; Wilhelmsen, Elva; Banim, Paul; Raymode, Parizade; Chilton, Andrew; Das, Debasish; Lee, Hye-Jeong; Curtis, Howard; Heneghan, Michael; Gess, Markus; Durant, Emma; Drake, IM; Bishop, Rebecca; Davies, Mervyn; Jones, Rebecca; Aldersley, Mark; Ncube, Noma; McNair, Alistair; Srirajaskanthan, Raj; Sen, Sambit; Casey, Rebecca; Bird, George; Mendall, Mike; Cowley, Caroline; Barnardo, Adrian; Kitchen, Paul; Yoong, Kevin; Amore, Kelly; Sirdefield, Dawn; Orpe, Jacky; Mathew, Ray; MacFaul, George; Wrigth, Aruna; Shah, Amir; Evans, Chris; Keggans, Janie; Bird, Bridget; Baxter, Gwen; Saha, Subrata; Pollock, Katharine; Hughes, Maggie; Bramley, Peter; Grieve, Emma; Young, Karin; Fraser, Andrew; Mukhopadhya, Ashis; Ocker, Kate; Mills, Peter; Hines, Francis; Shallcross, Chris; Wilkins, Joy; Grellier, Leonie; Campbell, Stewart; Martin, Kirsty; Bathgate, Andrew; Innes, Caron; Shepherd, Alan; Rushbrook, Simon; Valliani, Talal; Przemioslo, Robert; Fairlamb, Helen; Macdonald, Chris; Eastick, Anne; Metcalf, Jane; Tanqueray, Elizabeth; Shmueli, Udi; Holbrook, Becky; Davis, Andrew; Browning, Julie; Naqvi, Asifabbas; Walker, Kirsten; Lee, Tom; Verheyden, Juliette; Slininger, Susan; Ryder, Stephen D; Chapman, Roger; Collier, Jane; O'Donnell, Denise; Stafford, Lizzie; Williamson, Kate; Kent, Linda; Klass, Howard; Ninkovic, Mary; March, Linda; Cramp, Matthew; Simpson, Diane; Dickson, Christine; Sharer, Nicholas; Hayes, Maria; Goggin, Patrick; Quinne, Mary; Pearson, Sallyanne; Hoeroldt, Barbara; Jones, Linda; Wright, Alice; Booth, Jonathan; Loftus, Alison; Lipscomb, George; Dewhurst, Hannah; Gunter, Emma; Williams, Earl; Fouracres, Anna; Farrington, Liz; Graves, Lyn; Hussaini, Hyder; Stableforth, Bill; Marriott, Suzie; Ayres, Reuben; Leoni, Marina; Burroughs, Andrew; Marshall, Eileen; Thorburn, Douglas; Tyrer, David; Martin, Kate; Lombard, Martin; Patanwala, Imran; Dali-Kemmery, Lola; Lambourne, Victoria; Maltby, Julia; Vyas, Samir; Colley, Julie; Shinder, Bal; Singhal, Saket; Jones, Jayne; Mills, Marisa; Gleeson, Dermot; Carnahan, Mandy; Butterworth, Jeff; Boulton, Kerenza; Taylor, Natalie; George, Keith; Harding, Tim; Tregonning, Julie; Douglass, Andrew; Brown, Carly; Clifford, Gayle; Panter, Simon; Gocher, Denise; Shearman, Jeremy; Bray, Gary; Hamilton, Maria; Butcher, Graham; Forton, Daniel; Mclindon, John; Curtis, Janette; Das, Debashis; Shewan, Tracey; Cowan, Matthew; Whatley, Gregory; Nasseri, Mariam; Grover, Bob; Sivaramakrishnan, Nurani; Ducker, Samantha; Houghton, Kathryn; Jones, David; Griffiths, Laura; Tripoli, Sherill; Pitcher, Maxton; Shpuza, Ervin; White, Nikki; Ghosh, Deb; Douds, Andrew; Green, Marie; Brookes, Matthew; Cumlat, Lourdes; Wong, Voi Shim; Warner, Karen; Netherton, Kimberley; Mandal, Adtya; Jain, Snjiv; Gupta, Hemant; Sanghi, Pradeep; Pereira, Steve; Neuberger, James; Gunson, Bridget; Hirschfield, Gideon; Lim, Reina Teegan; Gallagher, Susan; Clement, Darren; Brind, Alison; Watts, Gill; Mupudzi, Mcdonald; Wright, Mark; Gitahi, Jane; Gordon, Fiona; Gocher, Denis; Unitt, Esther; Pateman, Hilary; Batham, Sally; Delahooke, Toby; Grant, Allister; Conder, Jill; Higham, Andrew; Cox, Mark; O'Donohoe, Lynn; Currie, Lynn; King, Alistair; Oblak, Metod; Collins, Carole; Whalley, Simon; Quinn, Marie; Baird, Yolanda; Amey, Isobel; Fraser, Jocelyn; Li, Andy; Cotterill, Donna; Bell, Andrew; Watson, Alan; Singhal, Amit; Gee, Ian; Greer, Sandra; Ang, Yeng; Ransford, Rupert; Allison, Joanna; Gotto, James; Dyer, Simon; Sweeting, Helen; Millson, Charles; Invernizzi, Pietro; Carbone, Marco; Cristoferi, Laura; Bonato, Giulia; Malinverno, Federica; Bernuzzi, Francesca; Alvaro, Domenico; Labbadia, Giancarlo; Bragazzi, Maria Consiglia; Andreone, Pietro; Muratori, Luigi; Azzaroli, Francesco; Floreani, Annarosa; Galli, Andrea; Tarocchi, Mirko; Giannini, Edoardo; Miele, Luca; Gasbarrini, Antonio; Grieco, Antonio; Marrone, Giuseppe; Donato, Maria Francesca; Valenti, Luca; Marra, Fabio; Marzioni, Marco; Maroni, Luca; Rigamonti, Cristina; Zuin, Massimo; Battezzati, Pier Maria; Picciotto, Antonino
Source
The Lancet Gastroenterology & Hepatology; September 2018, Vol. 3 Issue: 9 p626-634, 9p
Subject
Language
ISSN
24681253
Abstract
Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters.