학술논문
Adjunctive rifampicin for Staphylococcus aureusbacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial
Document Type
Article
Author
Thwaites, Guy E; Scarborough, Matthew; Szubert, Alexander; Nsutebu, Emmanuel; Tilley, Robert; Greig, Julia; Wyllie, Sarah A; Wilson, Peter; Auckland, Cressida; Cairns, Janet; Ward, Denise; Lal, Pankaj; Guleri, Achyut; Jenkins, Neil; Sutton, Julian; Wiselka, Martin; Armando, Gonzalez-Ruiz; Graham, Clive; Chadwick, Paul R; Barlow, Gavin; Gordon, N Claire; Young, Bernadette; Meisner, Sarah; McWhinney, Paul; Price, David A; Harvey, David; Nayar, Deepa; Jeyaratnam, Dakshika; Planche, Tim; Minton, Jane; Hudson, Fleur; Hopkins, Susan; Williams, John; Török, M Estee; Llewelyn, Martin J; Edgeworth, Jonathan D; Walker, A Sarah; Scarborough, Matthew; Kamfose, Musa; de Veciana, Ana; Gordon, Nicola Claire; Peto, Leon; Pill, Gemma; Clarke, Tiphanie; Watson, Laura; Young, Bernadette; Griffiths, Dai; Vaughn, Ali; Anson, Luke; Liu, Elian; Perera, Sanuki; Rylance-Knight, Lydia; Cantell, Carmen; Moroney, Ruth; Edgeworth, Jonathan D; Thwaites, Guy; Bisnauthsing, Karen; Querol-Rubiera, Antonio; Gibbs, Charlotte; Patel, Amita; Hemsley, Carolyn; Goodman, Anna L; Wyncoll, Duncan; Biswas, Jason; Fitzpatrick, Jennifer; Roberts, Lizzie; Millard, James; Stone, Neil; Cape, Angela; Hurley, Lisa; Tam, Chi Kai; Nsutebu, Emmanuel; Hoyle, Marie-Claire; Maitland, Kate; Trainor, Leona; Reynolds, Helen; Harrison, Jennifer; Anson, Jim; Lewis, Joseph; Folb, Jonathan; Goodwin, Lynsey; Beeching, Nicholas; Dyas, Sarah; Winslow, Helen; Foote, Elizabeth; Roberts, Paul; Natarajan, Pavithra; Chrdle, Alex; Fenech, Manuel; Allsop, Hannah; Tilley, Robert; Austin-Hutchison, Rachel; Barrett, Louise; Brookes, Karen; Carwithen, Leanne; Conbeer, Andrew; Cunningham, Richard; Eglinton, Charlotte; Fok, Rosie; Gott, Hannah; Hughes, Shona; Jones, Lewis; Kalita, Maggie; King, Angela; March, Linda; Marner, Mike; Mynes, Tracey; Plant, Aiden; Price, Suzanne; Sercombe, Judy; Stolton, Alison; Wallis, Mark; West, Marie-Claire; Westcott, Jackie; Williams, Claire; Wosley, Rob; Yabsley, Leona; Greig, Julia; Butland, Laura; Sorrell, Julie; Mitchell, Tamara; Alli, Abiola; Meiring, James; Masake, Boingotlo; Rowson, Carlene; Smart, Lynne; Makey, Laura; Moll, Sarah; Cunningham, Jane; Ryalls, Kim; Birchall, Kathryn; Middle, Janet; Jackson, Yvonne; Swift, Diane; Cole, Joby; Subramanian, Bala; Okhuoya, Faith; Edwards, Maria; Bailey, Cheryl; Warren, Rebecca; Islam, Gayti; Ankcorn, Michael; Birchall, Sarah; Jones, Paul; Humphries, John; Booth, Stephen; Evan, Cariad; Wyllie, Sarah; Flatt, Andrew; Strakova, Lenka; Hayes, Maria; Valentine, Stacey; James, Clare; Wands, Mary; Cortes, Nicolas; Khan, Nisa; Porter, Robert; Martin, Zoe; Yip, Keith; Preedy, Helen; Chesterfield, Helen; Dobson, Tracey; Walker, Colin; Llewelyn, Martin; Dunne, Angela; Latter, Laura; Porges, Alison; Price, James; Paul, John; Behar, Laura; Robinson, Louise; Murray, Amy; Fitzpatrick, Jennifer; Sargent, Tenessa; Ridley, Carrie; de Gordoa, Laura Ortiz-Ruiz; Gilliam, Deborah; McPherson, Carole; Matthews, Simon; Foreman, Emma; Jarghese, Rajesh; Beddoe, Alisha; Martin, Sebastien; Shaw, Sephora; Wlazly, Dominika; Cole, Maggie; Gihawi, Abraham; Cole, Kevin; Török, M Estée; Gouliouris, Theodore; Bedford, Luke; Saunderson, Rebecca B; Mariolis, Ilias; Bousfield, Rachel; Ramsay, Isobel; Greaves, Daniel; Aliyu, Sani; Cox, Kim; Mlemba, Lois; Whitehead, Lynne; Vyse, Naval; Bolton, Mark; Williams, John; Lambert, Pauline; Chadwick, David; Baillie, Kirsty; Cain, Martyn; Bellamy, Richard; Wong, Jason; Thompson, Jane; Vassallo, Helen; Skotnicka, Agnieszka; Boyce, Andrea; Donnelly, Anthony; Wilson, Peter; FitzGerald, Graham; Dean, Victoria; Warnes, Kristian; Reyes, Anna; Rahman, Saadia; Tsang, Lillian; Williams, Joanne; Morris-Jones, Stephen; Hopkins, Susan; Witness, Elen; Brady, Orla; Woodford, Elizabeth; Pettifer, Teresa; McCadden, Angela; Marks, Ben; Collier, Sophie; Mack, Damien; Warren, Simon; Brown, Colin; Lyons, Adrian; Taiyari, Sara; Mepham, Stephen; Sweeney, Anna; Brown, Li-An; Auckland, Cressida; Potter, Alison; Mandiza, Jess; Hough, Maxine; Williams, Sue; Renton, Caroline; Walters, Fiona; Nadolski, Maria; Evans, Andree; Tarrant, Polly; Curley, Katherine; Whiteley, Sophie; Halpin, Julia; Hutchings, Melanie; Todd, Shirley; Lohan, Christop; Chapter, Tamika; Folland, Emma; Colville, Alaric; Marden, Katy; Morgan, Marina; Fok, Rosie; Porter, Rob; Baxter, Mel; Minton, Jane; Rippon, Sarah; Cevik, Muge; Chapman, Judith; Kemp, Tim; Vincent, Rachel; Osborne, Dave; Platt, Tracey; Calderwood, James; Cook, Bernadette; Bedford, Caroline; Galloway-Browne, Leanne; Abberley, Nadine; Attack, Kelly; Allen, Joanna; Lal, Pankaj; Harrison, Melanie; Stevenson, Sarah; Brooks, Carol; Harlow, Paula; Ewing, Jordan; Cooper, Shirley; Balancio-Tolentino, Roderick; O'Neil, Laura; Tagney, Rebecca; Shackcloth, Daniela; Planche, Tim; Fellows, James; Millett, Ruth; Studham, Jo; de Souza, Cherrelle; Howell, Geoffrey; Greaves, Hezron; Foncel, Ella; Kurup, Rahul; Briggs, Jack; Smith, Melody; Suarez, Cristina; Sorrentino, Giordana; Scobie, Antonia; Houston, Angela; Ahmad, Fozia; Breathnach, Aodhan; Chahuan, Rakhee; Wilkins, Katie; Guleri, Achyut; Waddington, Natalia; Sharma, Rashmi; Flegg, Peter; Kollipara, Veenu; Alam, Mazhar; Potter, Andrew; Donaldson, Stacey; Armer, Charlote; Frudd, Julie; Jeyaratnam, Dakshika; Joy, Manju; Mathews, Asha; Glass, Stephen K; Ajayi, Ayodele; Fife, Amanda; Qaiser, Saba; Sheehan, Sharon; Muñoz-Villaverde, Sergio; Yogo, Noah; De Abreu, Ines; Notcheva, Gaynor; Flanagan, Joanna; Watson, Cordelia; Sais, Efisia; Adedayo, Adetunji; Chu, Vicky; Shaw, Georgina; Graver, Michelle A; Palmer, Rebecca; Palmer, Donna; Haile, Senait; Gordon, Joanne; Tam, Chi Kai; Mandar, Kirandip; Szypura, Weronika; Jenkins, Neil; Marange, Josephine; Shabangu, Vusumuzi; Moore, Katy; Lyons, Jill; Munang, Melinda; Sangombe, Mirriam; Moran, Ed; Hussain, Abid; Wiselka, Martin; Lewszuk, Adam; Batham, Sally; Ellis, Kate; Bahadur, Leila; White, Helena; Pareek, Manish; Sahota, Amandip; Coleman, Stephen; Pateman, Hilary; Kotecha, Atul; Sim, Christopher; Rosser, Andrew; Deane, Jill; Nendick, Richard; Aldridge, Catherine; Clarke, Anne; Wood, Michelle; Marshall, Adele; Stephenson, Lynsey; Matheson-Smith, Tracy; Sloss, John; Potts, Kathryn; Malkin, Joanne; Ftika, Lemonia; Raviprakash, Veena; Sutton, Julian; Malachira, Ahalya; Kean, Miranda; Criste, Kristine; Gladas, Kirsty; Andrews, Caroline; Hutchison, Clare; Adams, Ellen; Andrews, Janet; Romans, Belinda; Ridley, Nicola; Ekani, Melanie; Mitchell, Julie; Smith, Nicola; Clark, Tristan; Glover, Sarah; Reed, Robert; Yam, Tat; Burton, Holly; Said, Rasha; Harvey, David; Janvier, Amy; Jacob, Reni; Smalley, Chris; Fair, Alison; Lord, Susan; Ripalda, Kate; Wooldridge, Helen; Cotter, Luis; Cardoso, Gus; Strachan, Elaine; Kaler, Gagan; Mohamoodally, Adam; Lawrence, Emma; Prime, Zoe; Abrahams, Rachel; Price, David Ashley; Rigden, Lesley; Shewan, Laura; Cullen, Katherine; Emmerson, Ingrid; Martin, Karen; Wilson, Hesther; Higham, Charley; Taylor, Kathryn Louise; Ong, Edmund; Patel, Bijal; Bond, Helena; Gradwell, Janine; Widdrington, John; Graham, Clive; Thornthwaite, Sarah; Prentice, Scott; Poultney, Una; Crowther, Hannah; Fairlamb, Helen; Hetherington, Emily; Brewer, Chris; Banerjee, Suryabrata; Hamson, Clare; McSkeane, Anna; McWhinney, Paul; Sharratt, Paula; Thorpe, Joanne; Kimachia, Sue; Wilson, Helen; Jeffs, Benjamin; Masters, Leslie; Wilson, Jonathan; Platt, Judith; Burgess, Lisa; Chadwick, Paul; Jeans, Adam; Keatley, Claire; Moran, Amanda; Swann, Zoe; Pagett, Katherine; Peel, Alex; Howard, Jason; Meisner, Sarah; Maloney, Kate; Masdin, Avril; Wright, Louise; Barlow, Gavin; Crossman, Samantha; Lowthorpe, Vicki; Moore, Emma; Moss, Peter; Parkin, Angela; Wolstencroft, Adam; Warner, Bev; Tarbotton, Clare; Eyre, Alison; Anderson, Anne; Burdett, Tina; Driffill, Amy; Walker, Ann Sarah; Hudson, Fleur; Szubert, Alex; Cairns, Janet; Ward, Denise; Webb, Helen; Russell, Charlotte; Jackson, Brooke; Otiko, Damilola; Borg, Chiara; Masters, Lindsey; Islam, Zaheer; Díaz-Montaña, Carlos; Johnson, Debbie
Source
The Lancet; February 2018, Vol. 391 Issue: 10121 p668-678, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Staphylococcus aureusbacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureuskilling, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection.