학술논문
Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial
Document Type
Article
Author
Bath, Philip M; Woodhouse, Lisa J; Appleton, Jason P; Beridze, Maia; Christensen, Hanne; Dineen, Robert A; Duley, Lelia; England, Timothy J; Flaherty, Katie; Havard, Diane; Heptinstall, Stan; James, Marilyn; Krishnan, Kailash; Markus, Hugh S; Montgomery, Alan A; Pocock, Stuart J; Randall, Marc; Ranta, Annemarei; Robinson, Thompson G; Scutt, Polly; Venables, Graham S; Sprigg, Nikola; Christensen, L M; Bentsen, L; Krarup Hansen, C; Thomsen, T T; Kruuse, C; Jensen, H H; Hansen, S S; Petrovic, V; Beridze, N; Kakabadze, N; Kherkheulidze, T; Kakabadze, D; Toidze, I; Lobjanidze, N; Akiashvili, N; Tevdoradze, A; Khizanishvili, N; Tsanava, T; Taylor, R; Iniesta, I; Kok, J; Duignan, J; Funnell, M; Cariga, P; Rodriguez, M; Watson, I J; Tennant, S; Macleod, M; Furnace, J; Gow, H; Irvine, J; Joyson, A; Nelson, S; Taylor, V; Smith, M; Bellfield, R; Hairsine, B; Davies, R; Dodd, A; Corrigan, J; Doherty, M; Ahmed, A; Denniss, C; Johnson-Holland, S; Kay, K A; Palau, R Icart; Auld, G; Daboo, P; Erande, R; Grimwood, G; Hove, D; Howaniec, L; Redjep, O; Rangasamay, R; Butt, G; Sandler, D; Reddan, J; Stafford, S; McIlmoyle, J; Maguire, S; Murphy, P; Chambers, J; Guthrie, L; Osborn, M; Steele, A; Burn, M; Benford, A; Misra, A; Hilton, D; O'Brien, E; Amis, E; Finlay, S; Mitchell, J; Geraghty, O; Harvey, K; Hazel, B; Mashate, S; Wilding, P; Sajid, M; Ball, M; Gascoyne, R; Sivakumar, R; Wright, A; Chatterjee, K; Booth, S; Eccleson, H; Kelly, C; Leason, S; Perkins, C; Bruce, D; Brown, E; Clayton, S; Garside, M; Rogers, G; Lawrence, E; Mahmood, S; Watchurst, C; Chadha, D; Glover, L; Holford, L; Smith, K; Walstow, D; Williams, R; O'Shea, L; Goodsell, J; Athulathmudali, C; Barbon, E; Namushi, R; Jacob, P; Johnson, L; Morse, D; McGhee, C; Speirs, O; Atkinson, S; Peacocke, A; Langhorne, P; Graham, R; Wright, F; McAlpine, C; Ravindrane, A; Bajoriene, M; Matter, L; Windebank, S; Giallombardo, E; Dellafera, D; Eglinton, C; Wilson, J; Broughton, D; Chapman, K; Dixon, L; Zaidi, M; Ayes, K; Kessell, J; Manawadu, D; Adegbaju, O; Aeron-Thomas, J; Anderson, K; Brigden, A; Cattermole, E; Good, J; Hassan, S; Khoromana, E; Lee-Carbon, L; Marks, K; Mckenzie, E; Sikondari, N; Cooper, M; Whysall, K; Wynter, I; Bamford, J; Hassan, A; Wanklyn, P; Kambafwile, M; Makawa, L; Waugh, D; Veraque, E; Soliman, MGG; Arif, S; Brown, R; Butler, S; Hewitt, C; Hindle, J; Pusalkar, A; Beadle, H; Chan, K; Siddiqui, M; Dangri, P; Buddha, S; Asokanathan, A; Mistri, A; Eveson, D; Musarrat, K; Manning, L; Anand, S; Christian, P; Khan, S; Patel, C; Sein, M; Banns, J; Gibson, E; Gordon, T; Gruenbeck, Y; Wong, S; Datta, P; Bateman, G; Jackson, L; Needle, A; Duodu, Y; Oliver, R; Padilla-Harris, C; Barber, M; Esson, D; Brodie, F; McInnes, C; Fotherby, K; Butler, D; Morgan, D; Preece, K; Willberry, A; Dent, M; Hammonds, F; Hunt, J; Vernon, C; O'Kane, D; Faola, F; Lai, P; O'Callaghan, J; Smith, C; Price, C; Lakey, R; Riddell, V; Smith, A; Storey, G; Munshi, S; Buck, A; Clarke, J; Gilzeane, N; Godfrey, M; Keshvara, R; Richardson, C; Roffe, J; Ryan, L; Shelton, F; Sunman, W; Tittle, A; Tomlinson, J; Whittamore, K; Wilkes, G; Owusu-Agyei, P; Temple, N; Mangion, D; Hardwick, A; Netherton, K; Nor, A Mohd; Hyams, B; Norman, S; Persad, N; Ragab, S; Dickson, C; Dube, J; Jinks, E; Knops, K; Wadams, B; Ali, K; Gaylard, J; Spurling, G; Sztriha, L; Ajao, T; Alao, M; Chan, F K; Webster, P; Howard, P; Dobson, T J; Hyatt, L; Sims, D; Cunningham, J; Esisi, B; Cassidy, T; Bokhari, M; McClelland, B; Mokoena, B; Gunathilagan, G; Jones, S; Reader, M; Thomas, G; Tilby, S; Findlay, P; Barrett, F; Leslie, F; Ross, S; Shread, I; Okwera, J; Howe, J; Harrington, F; Courtauld, G; Schofield, C; Donnelly, R; Maddula, M; Scott, J; Beavan, J; Muhidden, K; Memon, I; Clarke, M; Hedstrom, A; Mills, L; Hemsley, A; Bowring, A; Boxall, L; Kingwell, H; Keenan, S; Roughan, C; Manoj, A; Cox, P; Fletcher, G; Lopez, P; Emsley, H; Gregary, B; McLoughlin, A; Raj, S; Roffe, C; Abano, N; Barry, A; Butler, A; Carpio, R; Castro, K; Finney, K; Gomm, S; Hiden, J; Grocott, J; Lyjko, S; Maguire, H; Remegoso, A; Sanyal, R; Stevens, S; Natarajan, I; Chembala, J; Muddegowda, G; Warusevitane, A; Blight, A; Balazikova, O; Lawlor, C; Shaw, L; Button, D; Howcroft, D; Lucas, S; Madigan, B; McCann, S; Dixit, A; Barkat, A; Davis, J; Fawcett, M; Finlay, L; Guy, H; Hays, C; Hogg, V; Horsley, E; Hubbuck, C; Pringle, C; Stevenson, C; Storey, K; Thompson, T; Woodward, S; Banerjee, A; Allcock, C; Merotra, S; Douglass, C; Campbell, E; Jarapa, R; Johnes, M; Keaveney, C; Marsden, T; Naing, Z; Perez, J; Shaw, K; Black, T; Anthony, A; Clarke, C; Paterson, J; Deighton, K; Temlett, E; Blank, C; Doyle, C; Duty, S; Gill, K; Harkness, K; Kamara, C; Richards, E; Elfandi, K; Guyler, P; Harman, P; Khuoge, C; Kunhunny, S; Tysoe, S; Moynihan, B; Adedoyin, T; Chopra, N; Dayal, N; Ghatala, R; Jeyaraj, N; Jones, I; Kennedy, F; Kerin, L; Khanom, N; Lewis, S; Maheswaran, S; Montague, L; Niemierko, M; O'Reilly, J; Trippier, S; Watson, F; Wilkinson, P; Young, E; Dizayee, K; Cochrane, H; O'Connell, J; Mokoena, L; Osborne, E; Nair, A; Greig, J; Jenkins, C; Powell, J; Price, F; Chowdhury, M; Brixey, S; Hunt, L; Rands, N; Rose, G; Stoddart, S; Srinivasan, M; Motherwell, N; Shekhar, R; Fuller, T; Lankester, A; Lingwood, P; Rankin, C; Webb, H; Jupp, B; Bell, J; Hann, G; Longland, B; Ovington, C; Bhaskaran, B; Ayres, G; Bailey, C; Bearne, H; Buxton, J; Fitzell, P; Hilaire, C; Kelly, D; Szabo, S; Tomlin, D; Gamble, E; Charles, B; Kumar, R; Fluskey, T; Mellor, Z; Peters, J; Sutton, V; Kenton, A; Martin, I; Nyabadza, S; Ghosh, S; Henry, M; Kumar, B; Bruce, D; Ambulo, C; Crawford, S; Nozedar, T; Platton, M; Cvoro, V; Couser, M; McCormick, K; Wilkinson, D; Javaid, K; Hurdowar, S; Attygalle, T; Sundayi, S; Orugun, O; Crowther, H; Jolly, R; Poultney, U; Azim, A; Krasinska-Chavez, M; White, J; Sengupta, N; Margalef, J; Metiu, M G; Meenakshisundaram, S; Dealing, S; Hargroves, D; Beranova, E; Cowie, L; Rudenko, H; Thomson, A; Verrion, A; Rashed, K; Board, S; Buckley, C; Hayward, D; Jenkins, K; Keeling, E; Rowland-Axe, R; Vickers, C; Wood, D; Lehman, A; Erande, R; Patel, M; Russell, H; Rehman, H; Forrest, D; Farren, P
Source
The Lancet; March 2018, Vol. 391 Issue: 10123 p850-859, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with that of guideline-based antiplatelet therapy.