학술논문
Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial
Document Type
Article
Author
Connolly, Stuart J; Eikelboom, John W; Bosch, Jackie; Dagenais, Gilles; Dyal, Leanne; Lanas, Fernando; Metsarinne, Kaj; O'Donnell, Martin; Dans, Anthony L; Ha, Jong-Won; Parkhomenko, Alexandr N; Avezum, Alvaro A; Lonn, Eva; Lisheng, Liu; Torp-Pedersen, Christian; Widimsky, Petr; Maggioni, Aldo P; Felix, Camilo; Keltai, Katalin; Hori, Masatsugu; Yusoff, Khalid; Guzik, Tomasz J; Bhatt, Deepak L; Branch, Kelley R H; Cook Bruns, Nancy; Berkowitz, Scott D; Anand, Sonia S; Varigos, John D; Fox, Keith A A; Yusuf, Salim; SALA, JORGELINA; CARTASEGNA, LUIS; VICO, MARISA; HOMINAL, MIGUEL ANGEL; HASBANI, EDUARDO; CACCAVO, ALBERTO; ZAIDMAN, CESAR; VOGEL, DANIEL; HRABAR, ADRIAN; SCHYGIEL, PABLO OMAR; CUNEO, CARLOS; LUQUEZ, HUGO; MACKINNON, IGNACIO J.; AHUAD GUERRERO, RODOLFO ANDRES; COSTABEL, JUAN PABLO; BARTOLACCI, INES PALMIRA; MONTANA, OSCAR; BARBIERI, MARIA; GOMEZ VILAMAJO, OSCAR; GARCIA DURAN, RUBEN OMAR; SCHIAVI, LILIA BEATRIZ; GARRIDO, MARCELO; INGARAMO, ADRIAN; BORDONAVA, ANSELMO PAULINO; PELAGAGGE, MARIA JOSE; NOVARETTO, LEONARDO; ALBISU DI GENNERO, JUAN PABLO; IBANEZ SAGGIA, LUZ MARIA; ALVAREZ, MOIRA; VITA, NESTOR ALEJANDRO; MACIN, STELLA MARIS; DRAN, RICARDO DARIO; CARDONA, MARCELO; GUZMAN, LUIS; SARJANOVICH, RODOLFO JUAN; CUADRADO, JESUS; NANI, SEBASTIAN; LITVAK BRUNO, MARCOS RAUL; CHACON, CAROLINA; MAFFEI, LAURA ELENA; GRINFELD, DIEGO; VENSENTINI, NATALIA; MAJUL, CLAUDIO RODOLFO; LUCIARDI, HECTOR LUCAS; GONZALEZ COLASO, PATRICIA DEL CARMEN; FERRE PACORA, FREDY ANTONI; VAN DEN HEUVEL, PAUL; VERHAMME, PETER; ECTOR, BAVO; DEBONNAIRE, PHILIPPE; VAN DE BORNE, PHILIPPE; LEROY, JEAN; SCHROE, HERMAN; VRANCKX, PASCAL; ELEGEERT, IVAN; HOFFER, ETIENNE; DUJARDIN, KARL; INDIO DO BRASIL, CLARISSE; PRECOMA, DALTON; ABRANTES, JOSE ANTONIO; MANENTI, EULER; REIS, GILMAR; SARAIVA, JOSE; MAIA, LILIA; HERNANDES, MAURO; ROSSI, PAULO; ROSSI DOS SANTOS, FABIO; ZIMMERMANN, SERGIO LUIZ; RECH, RAFAEL; ABIB JR, EDUARDO; LEAES, PAULO; BOTELHO, ROBERTO; DUTRA, OSCAR; SOUZA, WEIMAR; BRAILE, MARIA; IZUKAWA, NILO; NICOLAU, JOSE CARLOS; TANAJURA, LUIZ FERNANDO; SERRANO JUNIOR, CARLOS VICENTE; MINELLI, CESAR; NASI, LUIZ ANTONIO; OLIVEIRA, LIVIA; DE CARVALHO CANTARELLI, MARCELO JOSE; TYTUS, RICHARD; PANDEY, SHEKHAR; LONN, EVA; CHA, JAMES; VIZEL, SAUL; BABAPULLE, MOHAN; LAMY, ANDRE; SAUNDERS, KEVIN; BERLINGIERI, JOSEPH; KIAII, BOB; BHARGAVA, RAKESH; MEHTA, PRAVINSAGAR; HILL, LAURIE; FELL, DAVID; LAM, ANDY; AL-QOOFI, FAISAL; BROWN, CRAIG; PETRELLA, ROBERT; RICCI, JOSEPH A; GLANZ, ANTHONY; NOISEUX, NICOLAS; BAINEY, KEVIN; MERALI, FATIMA; HEFFERNAN, MICHAEL; DELLA SIEGA, ANTHONY; DAGENAIS, GILLES R; DAGENAIS, FRANCOIS; BRULOTTE, STEEVE; NGUYEN, MICHEL; HARTLEIB, MICHAEL; GUZMAN, RANDOLPH; BOURGEOIS, RONALD; RUPKA, DENNIS; KHAYKIN, YAARIV; GOSSELIN, GILBERT; HUYNH, THAO; PILON, CLAUDE; CAMPEAU, JEAN; PICHETTE, FRANCIS; DIAZ, ARIEL; JOHNSTON, JAMES; SHUKLE, PRAVIN; HIRSCH, GREGORY; RHEAULT, PAUL; CZARNECKI, WLODZIMIERZ; ROY, ANNIE; NAWAZ, SHAH; FREMES, STEPHEN; SHUKLA, DINKAR; JANO, GABRIEL; COBOS, JORGE LEONARDO; CORBALAN, RAMON; MEDINA, MARCELO; NAHUELPAN, LEONARDO; RAFFO, CARLOS; PEREZ, LUIS; POTTHOFF, SERGIO; STOCKINS, BENJAMIN; SEPULVEDA, PABLO; PINCETTI, CHRISTIAN; VEJAR, MARGARITA; TIAN, HONGYAN; WU, XUESI; KE, YUANNAN; JIA, KAIYING; YIN, PENGFEI; WANG, ZHAOHUI; YU, LITIAN; WU, SHULIN; WU, ZONGQUI; LIU, SHAO WEN; BAI, XIAO JUAN; ZHENG, YANG; YANG, PING; YANG, YUN MEI; ZHANG, JIWEI; GE, JUNBO; CHEN, XIAO PING; LI, JUNXIA; HU, TAO HONG; ZHANG, RUIYAN; ZHENG, ZHE; CHEN, XIN; TAO, LIANG; LI, JIANPING; HUANG, WEIJIAN; FU, GUOSHENG; LI, CHUNJIAN; DONG, YUGANG; WANG, CHUNSHENG; ZHOU, XINMIN; KONG, YE; SOTOMAYOR, ARISTIDES; ACCINI MENDOZA, JOSE LUIS; CASTILLO, HENRY; URINA, MIGUEL; AROCA, GUSTAVO; PEREZ, MARITZA; MOLINA DE SALAZAR, DORA INES; SANCHEZ VALLEJO, GREGORIO; FERNANDO, MANZUR J; GARCIA, HENRY; GARCIA, LUIS HERNANDO; ARCOS, EDGAR; GOMEZ, JUAN; CUERVO MILLAN, FRANCISCO; TRUJILLO DADA, FREDY ALBERTO; VESGA, BORIS; MORENO SILGADO, GUSTAVO ADOLFO; ZIDKOVA, EVA; LUBANDA, JEAN-CLAUDE; KALETOVA, MARKETA; KRYZA, RADIM; MARCINEK, GABRIEL; RICHTER, MAREK; SPINAR, JINDRICH; MATUSKA, JIRI; TESAK, MARTIN; MOTOVSKA, ZUZANA; BRANNY, MARIAN; MALY, JIRI; MALY, MARTIN; WIENDL, MARTIN; FOLTYNOVA CAISOVA, LENKA; SLABY, JOSEF; VOJTISEK, PETR; PIRK, JAN; SPINAROVA, LENKA; BENESOVA, MIROSLAVA; CANADYOVA, JULIA; HOMZA, MIROSLAV; FLORIAN, JINDRICH; POLASEK, ROSTISLAV; COUFAL, ZDENEK; SKALNIKOVA, VLADIMIRA; BRAT, RADIM; BRTKO, MIROSLAV; JANSKY, PETR; LINDNER, JAROSLAV; MARCIAN, PAVEL; STRAKA, ZBYNEK; TRETINA, MARTIN; DUARTE, YAN CARLOS; POW CHON LONG, FREDDY; SANCHEZ, MAYRA; LOPEZ, JOSE; PERUGACHI, CARMITA; MARMOL, RICARDO; TRUJILLO, FREDDY; TERAN, PABLO; TUOMILEHTO, JAAKKO; TUOMILEHTO, HENRI; TUOMINEN, MARJA-LEENA; TUOMILEHTO, HENRI; KANTOLA, ILKKA; STEG, GABRIEL; ABOYANS, VICTOR; LECLERCQ, FLORENCE; FERRARI, EMILE; BOCCARA, FRANCK; MESSAS, EMMANUEL; MISMETTI, PATRICK; SEVESTRE, MARIE ANTOINETTE; CAYLA, GUILLAUME; MOTREFF, PASCAL; STOERK, STEFAN; DUENGEN, HANS-DIRK; STELLBRINK, CHRISTOPH; GUEROCAK, OSMAN; KADEL, CHRISTOPH; BRAUN-DULLAEUS, RUEDIGER; JESERICH, MICHAEL; OPITZ, CHRISTIAN; VOEHRINGER, HANS-FRIEDRICH; APPEL, KARL-FRIEDRICH; WINKELMANN, BERNHARD; DORSEL, THOMAS; NIKOL, SIGRID; DARIUS, HARALD; RANFT, JURGEN; SCHELLONG, SEBASTIAN; JUNGMAIR, WOLFGANG; DAVIERWALA, PIROZE; VORPAHL, MARC; BAJNOK, LASZLO; LASZLO, ZOLTAN; NOORI, EBRAHIM; VERESS, GABOR; VERTES, ANDRAS; ZSARY, ANDRAS; KIS, ERNO; KORANYI, LASZLO; BAKAI, JUDIT; BODA, ZOLTAN; POOR, FERENC; JARAI, ZOLTAN; KEMENY, VENDEL; BARTON, JOHN; MCADAM, BRENDAN; MURPHY, ANDREW; CREAN, PETER; MAHON, NIALL; CURTIN, RONAN; MACNEILL, BRIAIN; DINNEEN, SEAN; HALABI, MAJDI; ZIMLICHMAN, REUVEN; ZELTSER, DAVID; TURGEMAN, YOAV; KLAINMAN, ELIEZER; LEWIS, BASIL; KATZ, AMOS; ATAR, SHAUL; ZIMLICHMAN, REUVEN; NIKOLSKY, EUGENIA; BOSI, STEFANO; NALDI, MONICA; FAGGIANO, POMPILIO; ROBBA, DEBORA; MOS, LUCIO; SINAGRA, GIANFRANCO; COSMI, FRANCO; OLTRONA VISCONTI, LUIGI; CARMINE, DE MATTEIS; DI PASQUALE, GIUSEPPE; DI BIASE, MATTEO; MANDORLA, SARA; BERNARDINANGELI, MARINO; PICCINNI, GIOVANNI CARLO; GULIZIA, MICHELE MASSIMO; GALVANI, MARCELLO; VENTURI, FLAVIO; MOROCUTTI, GIORGIO; BALDIN, MARIA GRAZIA; OLIVIERI, CARLO; PERNA, GIAN PIERO; CIRRINCIONE, VINCENZO; KANNO, TAKAYASU; DAIDA, HIROYUKI; OZAKI, YUKIO; MIYAMOTO, NAOMASA; HIGASHIUE, SHINICHI; DOMAE, HIROSHI; HOSOKAWA, SHINOBU; KOBAYASHI, HIROO; KURAMOCHI, TAKEHIKO; FUJII, KENSHI; MIZUTOMI, KAZUAKI; SAKU, KEIJIRO; KIMURA, KAZUO; HIGUCHI, YOSHIHARU; ABE, MITSUNORI; OKUDA, HARUHITO; NODA, TOSHIYUKI; MITA, TERUAKI; HIRAYAMA, ATSUSHI; ONAKA, HARUHIKO; INOKO, MORIAKI; HIROKAMI, MITSUGU; OKUBO, MUNENORI; AKATSUKA, YUTAKA; IMAMAKI, MIZUHO; KAMIYA, HARUO; MANITA, MAMORU; HIMI, TOSHIHARU; UENO, HIDEKI; HISAMATSU, YUJI; AKO, JUNYA; NISHINO, YASUHIRO; KAWAKAMI, HIDEO; YAMADA, YUTAKA; KORETSUNE, YUKIHIRO; YAMADA, TAKAHISA; YOSHIDA, TETSURO; SHIMOMURA, HIDEKI; KINOSHITA, NORIYUKI; TAKAHASHI, AKIHIKO; YUSOFF, KHALID; WAN AHMAD, WAN AZMAN; ABU HASSAN, MUHAMMAD RADZI; KASIM, SAZZLI; ABDUL RAHIM, AIZAI AZAN; MOHD ZAMRIN, DIMON; MACHIDA, MASAHARU; HIGASHINO, YORIHIKO; UTSU, NORIAKI; NAKANO, AKIHIKO; NAKAMURA, SHIGERU; HASHIMOTO, TETSUO; ANDO, KENJI; SAKAMOTO, TOMOHIRO; PRINS, F.J.; LOK, DIRK; MILHOUS, JOHANNES GERT-JAN; VIERGEVER, ERIC; WILLEMS, FRANK; SWART, HENK; ALINGS, MARCO; BREEDVELD, ROB; DE VRIES, KEES-JAN; VAN DER BORGH, ROGER; OEI, FANNY; ZOET-NUGTEREN, STIENEKE; KRAGTEN, HANS; HERRMAN, JEAN PAUL; VAN BERGEN, PAUL; GOSSELINK, MARCEL; HOEKSTRA, EDUARD; ZEGERS, ERWIN; RONNER, EELKO; DEN HARTOG, FRANK; BARTELS, GERARD; NIEROP, PETER; VAN DER ZWAAN, COEN; VAN ECK, JACOB; VAN GORSELEN, EDWIN; GROENEMEIJER, BJORN; HOOGSLAG, PIETER; DE GROOT, MARC ROBERT; LOYOLA, ALDRIN; SULIT, DENNIS JOSE; REY, NANNETTE; ABOLA, MARIA TERESA; MORALES, DANTE; PALOMARES, ELLEN; ABAT, MARC EVANS; ROGELIO, GREGORIO; CHUA, PHILIP; DEL PILAR, JOSE CARLO; ALCARAZ, JOHN DENNIS; EBO, GERALDINE; TIRADOR, LOUIE; CRUZ, JOSEFINA; ANONUEVO, JOHN; PITARGUE, ARTHUR; JANION, MARIANNA; GUZIK, TOMASZ; GAJOS, GRZEGORZ; ZABOWKA, MACIEJ; RYNKIEWICZ, ANDRZEJ; BRONCEL, MARLENA; SZUBA, ANDRZEJ; CZARNECKA, DANUTA; MAGA, PAWEL; STRAZHESKO, IRINA; VASYUK, YURY; SIZOVA, ZHANNA; POZDNYAKOV, YURY; BARBARASH, OLGA; VOEVODA, MIKHAIL; POPONINA, TATIANA; REPIN, ALEXEY; OSIPOVA, IRINA; EFREMUSHKINA, ANNA; NOVIKOVA, NINA; AVERKOV, OLEG; ZATEYSHCHIKOV, DMITRY; VERTKIN, ARKADIY; AUSHEVA, AZA; COMMERFORD, PATRICK; SEEDAT, SAADIYA; VAN ZYL, LOUIS; ENGELBRECHT, JAN; MAKOTOKO, ELLEN MAKONLI; PRETORIUS, CATHARINA ELIZABETH; MOHAMED, ZAID; HORAK, ADRIAN; MABIN, THOMAS; KLUG, ERIC; BAE, JANG-HO; KIM, CHEOLHO; KIM, CHONG-JIN; KIM, DONG-SOO; KIM, YONG JIN; JOO, SEUNGJAE; HA, JONG-WON; PARK, CHUL SOO; KIM, JANG YOUNG; KIM, YOUNG-KWON; JARNERT, CHRISTINA; MOOE, THOMAS; DELLBORG, MIKAEL; TORSTENSSON, INGEMAR; ALBERTSSON, PER; JOHANSSON, LARS; AL-KHALILI, FARIS; ALMROTH, HENRIK; ANDERSSON, TOMMY; PANTEV, EMIL; TENGMARK, BENGT-OLOV; LIU, BO; RASMANIS, GUNDARS; WAHLGREN, CARL-MAGNUS; MOCCETTI, TIZIANO; PARKHOMENKO, ALEXANDER; TSELUYKO, VIRA; VOLKOV, VOLODYMYR; KOVAL, OLENA; KONONENKO, LYUDMYLA; PROKHOROV, OLEKSANDR; VDOVYCHENKO, VALERIY; BAZYLEVYCH, ANDRIY; RUDENKO, LEONID; VIZIR, VADYM; KARPENKO, OLEKSANDR; MALYNOVSKY, YAROSLAV; KOVAL, VALENTYNA; STOROZHUK, BORYS; COTTON, JAMES; VENKATARAMAN, ASOK; MORIARTY, ANDREW; CONNOLLY, DEREK; DAVEY, PATRICK; SENIOR, ROXY; BIRDI, INDERPAUL; CALVERT, JOHN; DONNELLY, PATRICK; TREVELYAN, JASPER; CARTER, JUSTIN; PEACE, AARON; AUSTIN, DAVID; KUKREJA, NEVILLE; HILTON, THOMAS; SRIVASTAVA, SUNNY; WALSH, RONALD; FIELDS, RONALD; HAKAS, JOSEPH; PORTNAY, EDWARD; GOGIA, HARINDER; SALACATA, ABRAHAM; HUNTER, JOHN J.; BACHARACH, J MICHAEL; SHAMMAS, NICOLAS; SURESH, DAMODHAR; SCHNEIDER, RICKY; GURBEL, PAUL; BANERJEE, SUBHASH; GRENA, PAUL; BEDWELL, NOEL; SLOAN, STEPHEN; LUPOVITCH, STEVEN; SONI, ANAND; GIBSON, KATHLEEN; SANGRIGOLI, RENEE; MEHTA, RAJENDRA; I-HSUAN TSAI, PETER; GILLESPIE, EVE; DEMPSEY, STEPHEN; HAMROFF, GLENN; BLACK, ROBERT; LADER, ELLIS; KOSTIS, JOHN B.; BITTNER, VERA; MCGUINN, WILLIAM; BRANCH, KELLEY; MALHOTRA, VINAY; MICHAELSON, STEPHEN; VACANTE, MICHAEL; MCCORMICK, MATTHEW; ARIMIE, RALUCA; CAMP, ALAN; DAGHER, GEORGE; KOSHY, N. MATHEW; THEW, STEPHEN; COSTELLO, FREDERICK; HEIMAN, MARK; CHILTON, ROBERT; MORAN, MICHAEL; ADLER, FREDRIC; COMEROTA, ANTHONY; SEIWERT, ANDREW; FRENCH, WILLIAM; SEROTA, HARVEY; HARRISON, ROBERT; BAKAEEN, FAISAL; OMER, SHUAB; CHANDRA, LOKESH; WHELAN, ALAN; BOYLE, ANDREW; ROBERTS-THOMSON, PHILIP; ROGERS, JAMES; CARROLL, PATRICK; COLQUHOUN, DAVID; SHAW, JAMES; BLOMBERY, PETER; AMERENA, JOHN; HII, CHRIS; ROYSE, ALISTAIR; SINGH, BHUWAN; SELVANAYAGAM, JOSEPH; JANSEN, SHIRLEY; LO, WINGCHI; HAMMETT, CHRISTOPHER; POULTER, ROHAN; NARASIMHAN, SESHASAYEE; WIGGERS, HENRIK; NIELSEN, HENRIK; GISLASON, GUNNAR; KOBER, LARS; HOULIND, KIM; BOENELYKKE SOERENSEN, VIBEKE; DIXEN, ULRIK; REFSGAARD, JENS; ZEUTHEN, ELISABETH; SOEGAARD, PETER; HRANAI, MARIAN; GASPAR, LUDOVIT; PELLA, DANIEL; HATALOVA, KATARINA; DROZDAKOVA, ERIKA; COMAN, IOAN; DIMULESCU, DOINA; VINEREANU, DRAGOS; CINTEZA, MIRCEA; SINESCU, CRINA; ARSENESCU, CATALINA; BENEDEK, IMRE; BOBESCU, ELENA; DOBREANU, DAN; GAITA, DAN; IANCU, ADRIAN; ILIESIU, ADRIANA; LIGHEZAN, DANIEL; PETRESCU, LUCIAN; PIRVU, OCTAVIAN; TEODORESCU, IULIA; TESLOIANU, DAN; VINTILA, MARIUS MARCIAN; CHIONCEL, OVIDIU
Source
The Lancet; January 2018, Vol. 391 Issue: 10117 p205-218, 14p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease.