학술논문
Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial
Document Type
Article
Author
Petrie, John R; Chaturvedi, Nishi; Ford, Ian; Brouwers, Martijn C G J; Greenlaw, Nicola; Tillin, Therese; Hramiak, Irene; Hughes, Alun D; Jenkins, Alicia J; Klein, Barbara E K; Klein, Ronald; Ooi, Teik C; Rossing, Peter; Stehouwer, Coen D A; Sattar, Naveed; Colhoun, Helen M; Nickerson, H; Lou, O; Dutta, S; Haw, J; Anderson, C; Kean, S; Thomson, E; Gillespie, L; Gibb, J; Greenlaw, N; Keech, A; Jenkins, A; March, K; Williams, S; Coady, E; Bots, M; Dreyer, J; Jan, T; Sheffy, K; Lusky, R; Peleg, S; Shore, A; Carty, D; Donnan, P; Witham, M; Adler, A; Lonn, E; Rauchhaus, P; Lindsay, R; Brouwers, M; Van-Melckebeke, J; Gillespie, L; Hamill, T; Cuthbertson, L; Murray, A; Jolly, L; Miller, E; Hair, J; Bell, A; Carmichael, S; Douglas, E; Surtees, P; Dinnett, E; Allan, J; Watson, C; McLaughlin, M; Brindley, G; Smillie, E; Motherwell, D; MacDonald, S; Ellis, P; Stuart, D; Travers, M; Brearley, S; Greig, L; Colman, P; Nankervis, A; Forulanos, S; West, D; Vaughan, S; Bjorasen, M; Donlan, J; Vrazas, J; O'Neal, D; Horsburgh, J; Pater, H; Kent, S; Twigg, S; Fulcher, G; Denner, R; Piotrowicz, A; Januszewski, A; Coy, A; Paul, T; McDonald, C; Tereschyn, S; Schmidt, N; Weingert, M; Heard, H; Burke, S; Ooi, TC; Lochnan, H; Sorisky, A; Keely, E; Malcolm, J; Maranger, J; Favreau, C; Petherick, S; Boles, K; Rossing, P; Hansen, TW; Lund, S; Hemmingsen, B; Thorogood, N; Green, K; Robinson, T; Abouglilia, K; Nayman, D; Miller, C; Warren, R; Aizawa, K; Balasubramani, M; Toth, S; Harvey, K; Birch, G; Atkin, S; Sathyapalan, T; James, A; Javed, Z; Wilding, J; Martin, B; Birch, S; Wilcox, A; Watson, N; Oliver, N; Jugnee, N; Rutter, M; Turgut, T; Shaju, A; Yau, S; Subin, S; Walker, M; Wake, D; Miller, C; Millward, A; Chong, P; Hibbert, M; George, J; Schaper, N; Pinxt, J; op het Roodt, J; Phillips, Sam; Murray, L; Sleigh, L; Collier, A; Sit, LE; Allan, K; Cook, J; Campbell, K; Hodge, L; Leese, G; Reekie, G; Jaap, A; Sudworth, A; White, A; McKnight, J; Steven, L; McKay, G; Llano, A; Currie, G; Lennon, E; Johnstone, J; Shields, K
Source
The Lancet Diabetes & Endocrinology; August 2017, Vol. 5 Issue: 8 p597-609, 13p
Subject
Language
ISSN
22138587; 22138595
Abstract
Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease.