부산대학교 도서관

Abstract: Carbamylation is an irreversible process of non-enzymatic modification of proteins by the breakdown products of urea. The degree of carbamylation has been proposed as an indicator of the control of uremia by dialysis. Our aim is to study potential determinants of carbamylated hemoglobin (CarbHb) and the relationship between CarbHb with dialysis adequacy and common complications of CRF. The study was carried out on 35 patients with CRF on regular hemodialysis (HD) (group 1), 35 patients with CRF on conservative treatments (group 2), and 35 normal controls (group 3). For all groups complete history, clinical examination, routine laboratory investigations, ECG, efficiency of dialysis for group 1 using KT/V, nerve conduction, resting ECG, and CarbHb level were taken. In HD patients, CarbHb correlates with Kt/V (P < 0.001) and neuropathy (P = 0.004). Mean CarbHb is 129.47 ± 23.50, 88.09 ± 9.41, and 30.7950 ± 1.9395 μg CV/g Hb for groups 1, 2, and 3, respectively. ROC curve CarbHb with resting ECG shows the area under the curve (0.765, 0.718) for group 1 and 2, respectively. ROC curve study for CarbHb and nerve affection shows group area under the curve (0.766, 0.551) for group 1 and 2, respectively. CarbHb is higher in uremia and more with regular HD than in patients under conservative treatment. In HD patients CarbHb correlates with KT/V and can be used as a supportive measure for adequacy of dialysis. The presence of complications like IHD and neuropathy in dialysis patients correlates with CarbHb, which can be used as a marker for the tendency to develop these complications.