부산대학교 도서관

A large proportion of the genome of most higher eukaryotes consists of transcriptionally-repressed repetitive DNA. To better understand how repressed chromatin states are inherited from one generation to the next, we performed a genome-wide RNA interference screen in Caenorhabditis elegans to identify genes required for the quantitative repression of an integrated multicopy transgene array in somatic cells. This revealed that inhibition of many components of the DNA replication machinery during early embryonic development leads to a global reduction in levels of the repressive histone post-translational modification H3K27me3 across the genome and a global increase in the levels of the active modifications H3K4me3 and H3K36me3. These results contribute to our understanding of inheritance of chromatin states.
Programa de doctorat en Biomedicina