학술논문
Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.
Document Type
Author
Source
BMC Cancer BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation. 14(1)
Subject
Language
English
ISSN
1471-2407
Abstract
Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.