학술논문
Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Document Type
Author
Khalili, Bita; Lee, Yunsung; Li-Gao, Ruifang; Masso, Jaan; Myhre, Ronny; Palviainen, Teemu; Rietveld, Cornelius; Koellinger, Philipp D.; Kweon, Hyeokmoon; Burik, Casper; Ning, Yuchen; Ahlskog, Rafael; Xia, Charley; Abner, Erik; Bao, Yanchun; Bhatta, Laxmi; Faquih, Tariq; de Feijter, Maud; Fisher, Paul; Gelemanović, Andrea; Giannelis, Alexandros; Hottenga, Jouke-Jan; Teumer, Alexander; Verweij, Resnke; Willoughby, Emily; Agerbo, Esben; Bergmann, Sven; Boomsma, D; Borglum, Anders; Brumpton, Ben; Davies, Neil; Esko, Tonu; Gordon, Scott D; Homuth, Georg; Ikram, M Arfan; Johannesson, Magnus; Kaprio, Jaakko; Kidd, Michael; Kutalik, Zoltán; Kwong, Alex; Lee, James J.; Luik, Annemarie; Magnus, Per; Marques-Vidal, Pedro; Martin, Nicholas G; Mook-Kanamori, Dennis; Mortensen, Preben; Oskarsson, Sven; Pedersen, Emil; Polašek, Ozren; Rosendaal, Frits; Smart, Melissa C.; Snieder, Harold; van der Most, Peter J; Vollenweider, Peter; Völzke, Henry; Willemsen, Gonneke; Beauchamp, Jonathan; DiPrete, Thomas; Karlsson Linnér, Richard; Lu, Qiongshi; Morris, Tim; Okbay, Aysu; Harden, K; Abdellaoui, Abdel; Hill, William; de Vlaming, Ronald; Benjamin, Daniel
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Subject
Language
English
Abstract
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes. Our GWAS-derived polygenic index captures 1 - 4% of income variance, with only one-fourth attributed to direct genetic effects. A phenome-wide association study using this polygenic index showed reduced risks for a broad spectrum of diseases, including hypertension, obesity, type 2 diabetes, coronary atherosclerosis, depression, asthma, and back pain. The income factor showed a substantial genetic correlation (0.92, s.e. = .006) with educational attainment (EA). Accounting for EA's genetic overlap with income revealed that the remaining genetic signal for higher income related to better mental health but reduced physical health benefits and increased participation in risky behaviours such as drinking and smoking.