부산대학교 도서관

Background: Febrile infection-related epilepsy syndrome (FIRES) describes a rare epilepsy syndrome in childhood in which refractory status epilepticus occurs following a febrile infection. The factors effecting the outcome are so far unknown.Objective: The aim is the identification of clinical predictors that enable an estimation of the outcome during the acute phase.Material and methods: A retrospective observational study was carried out with 93 children, descriptive statistics with the collection of 31 parameters, selection of 12 independent variables and exploratory analysis of the effect of the variables on the outcome using multiple linear regression analysis, definition of the outcome based on the modified Rankin scale for children (poor outcome defined as 4–6 points).Results: Intubation anesthesia was necessary to stop the status epilepticus in 67.2% of the children. A longer duration of intubation correlated with a worse outcome. Children who were intubated and ventilated for more than 8 weeks consistently showed a poor outcome.Conclusion: After more than 8 weeks of intubation, the probability of a good outcome is estimated as being very low, so that a change of the treatment goal to a palliative treatment must be considered.