학술논문
Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats
Document Type
Original Paper
Author
da Silva Costa, Nathalia; de Araujo, Joana Ramos; da Silva Melo, Manuela Fernandes; da Costa Mota, Jéssica; Almeida, Patricia Pereira; Coutinho-Wolino, Karen Salve; Da Cruz, Beatriz Oliveira; Brito, Michele Lima; de Souza Carvalho, Thaís; Barreto-Reis, Emanuelle; de Luca, Beatriz Gouvêa; Mafra, Denise; Magliano, D.’Angelo Carlo; de Souza Abboud, Renato; Rocha, Ramon Silva; da Cruz, Adriano Gomes; de Toledo Guimarães, Jonas; Stockler-Pinto, Milena Barcza
Source
Probiotics and Antimicrobial Proteins. :1-15
Subject
Language
English
ISSN
1867-1306
1867-1314
1867-1314
Abstract
Dairy foods have become an interest in chronic kidney disease (CKD) due to their nutritional profile, which makes them a good substrate for probiotics incorporation. This study evaluated the effect of probiotic-enriched Minas cheese with Lactobacillus acidophilus La-05 in an experimental rat model for CKD on cardiac, inflammatory, and oxidative stress parameters. Male Wistar rats were divided into 4 groups (n = 7/group): 5/6 nephrectomy + conventional Minas cheese (NxC); 5/6 nephrectomy + probiotic Minas cheese (NxPC); Sham + conventional Minas cheese (ShamC); Sham + probiotic Minas cheese (ShamPC). Offering 20 g/day of Minas cheese with Lact. acidophilus La-05 (108 –109 log CFU/g) for 6 weeks. The cardiomyocyte diameter was determined. Superoxide dismutase (SOD) activity in plasma, heart, kidney, and colon tissue was performed. At the end of supplementation, no significant changes in lipid profile and renal parameters were found. The NxPC group showed a decrease in cardiomyocyte diameter compared to the NxC group (16.99 ± 0.85 vs. 19.05 ± 0.56 μm, p = 0.0162); also they showed reduced plasmatic SOD activity (502.8 ± 49.12 vs. 599.4 ± 94.69 U/mL, p < 0.0001). In summary, probiotic-enriched Minas cheese (Lact. acidophilus La-05) consumption suggests a promisor cardioprotective effect and was able to downregulate SOD activity in a rat model of CKD.Graphical Abstract: