부산대학교 도서관

Age-related cataracts are the leading cause of visual impairment among older adults. Many significant cases remain undiagnosed or neglected in communities, due to limited availability or accessibility to cataract screening. In the present study, we report the development and validation of a retinal photograph-based, deep-learning algorithm for automated detection of visually significant cataracts, using more than 25,000 images from population-based studies. In the internal test set, the area under the receiver operating characteristic curve (AUROC) was 96.6%. External testing performed across three studies showed AUROCs of 91.6–96.5%. In a separate test set of 186 eyes, we further compared the algorithm’s performance with 4 ophthalmologists’ evaluations. The algorithm performed comparably, if not being slightly more superior (sensitivity of 93.3% versus 51.7–96.6% by ophthalmologists and specificity of 99.0% versus 90.7–97.9% by ophthalmologists). Our findings show the potential of a retinal photograph-based screening tool for visually significant cataracts among older adults, providing more appropriate referrals to tertiary eye centers.
Age-related cataracts are characterized by clouding of the eye’s lens and cause vision impairment or loss. Here the authors develop a retinal photograph-based deep-leaning method to detect visually significant cataracts and report that it detects cataracts with similar accuracy to ophthalmologists.