학술논문
Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
Document Type
Original Paper
Author
Navarrete-Muñoz, Eva-Maria; Vioque, Jesus; Toledo, Estefanía; Oncina-Canovas, Alejando; Martínez-González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Fitó, Montserrat; Romaguera, Dora; Alonso-Gómez, Ángel M.; Wärnberg, Julia; Martínez, J. Alfredo; Serra-Majem, Luís; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, José; Pintó, Xavier; Tur, Josep A.; López-Miranda, José; Bueno-Cavanillas, Aurora; Matía-Martín, Pilar; Daimiel, Lidia; Sánchez, Vicente Martín; Vidal, Josep; de Cos Blanco, Ana Isabel; Ros, Emili; Diez-Espino, Javier; Babio, Nancy; Fernandez-Carrion, Rebeca; Castañer, Olga; Colom, Antoni; Compañ-Gabucio, Laura; Lete, Itziar Salaverria; Crespo-Oliva, Edelys; Abete, Itziar; Tomaino, Laura; Casas, Rosa; Fernandez-Garcia, José Carlos; Santos-Lozano, José Manuel; Sarasa, Iziar; Gámez, José M.; Garcia-Rios, José M. Antonio; Martín-Pelaez, Sandra; Ruiz-Canela, Miguel; Díaz-López, Andrés; Martinez-Lacruz, Raul; Zomeño, Maria Dolors; Rayó, Elena; Sellés, Cristina Gisbert; Canudas, Silvia; Goday, Albert; García-de-la-Hera, Manoli
Source
European Journal of Nutrition. 60(2):1125-1136
Subject
Language
English
ISSN
1436-6207
1436-6215
1436-6215
Abstract
Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial.Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders.Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead.Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.