학술논문

Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study
Document Type
Original Paper
Author
Abbas, Z.Abburu, S.Abd Ghaffar, M. K.Abdelhadi, M.Abdikadir, H. R.Abdulmajid, A.Abid, H.Abid, A.Abuhussein, N.Abul, M. H.Acquaah, F.Acres, M.Adams, R.Adams, R. D.Adebayo, A. A.Adeleja, I.Adjei, H.Afzal, Z.Agarwal, V.Ahern, N.Ahmad, K.Ahmad, S.Ahmed, M.Ahmed, H.Ahmed, N.Ahmed, S.Ahmed, F.Ahn, J. S.Aidoo-Micah, G. E.Aildasani, L.Aithie, J. M.Akhtar, S.Ali, S.Ali, A.Ali, B.Ali, M.Ali, H.Alizadeh, M.Allan, C.Allen, J. L. Y.Allot, R.Al-Mousawi, A.Al-Obaedi, O.Al-Robeye, A.Amajuoyi, A.Amin, H.Amin, O.Amphlett, A. H.Anandarajah, C.Anderson, L.Anderson, L. B.Anderson, S. M.Ang, A.Angelov, S.Anilkumar, A.Anim-Addo, N.Ansari, N.Antoniou, I.Archer, C. H.Arif, T.Asbjoernsen, C. A.Ashfaq, U.Ashken, L.Ashraf, S. F.Ashraf, S.Ashton, A. J.Ashwood, J.Aslanyan, A.Asmadi, A.Assadullah, S.Atayi, A.Atraszkiewicz, B. A.Attalla, M.Austreng, L.Auyoung, E.Avery, P.Axelson, T.Aziz, H.Aziz, N.Baker, A. N.Bakewell, Z. R.Bakhsh, A.Balaji, S.Balian, V.Bamgbose, F. A.Barai, I.Barnes, J.Barrow, T. R.Barthorpe, A. E.Bartlett, J.Bartlett, R. D.Barton, E. C.Bassam, N.Bassett, J.Bassiony, S.Bath, M. F.Batho, A.Batt, E.Bazeer, H. Z.Beckett, J.Beecroft, S.Behar, N.Bell, N.Bell, L.Bell, A.Bemand, T. P.Bergara, T.Bernstein, I.Bethell, G. S.Bhanderi, S.Bhangu, A.Bhaskaran, G.Bhatt, N.Bhatti, M.Bhome, R.Bhudia, R.Bingham, G.Blege, H. K.Blessed, R.Bloomer, J.Bloomfield, T.Blore, C. D.Bolton, W.Bolton, L.Bonsu, S.Bookless, L. R.Bose, R.Botchey, S.Boulton, A. J.Boxall, N.Boyle, J.Braganza, L.Brathwaite-Shirley, C.Bravo, M.Brecher, J.Bremner, R. H.Brennan, C.Brennan, E.Brennan, K.Brent, G.Brewer, C. F.Brewster, O.Bright, M.Brown, D.Brown, E.Brown, F. S.Brown, E. J.Broyd, A.Brzyska, K.Buakuma, P.Buchan, A. M.Buckle, R. T.Bucko, A. M.Bulley, F.Bullman, L. M.Bullock, N. P.Burgess, A.Burke, J.Burke, D.Burke, E.Burney, L. J.Callan, R.Campbell, J.Canning, N.Canning, E.Cao, Y.Cardwell, A. E.Carr, L.Carr, R.Carroll, A. F.Carter, D.Carthew, L.Chamberlain, M.Chan, N.Chan, C.Chandan, N.Chapman, S. J.Charalambos, M. A.Charalambous, G.Charania, A.Charavanamuttu, V.Chaudhary, M.Chaudhry, F. I.Chaudhry, W. W.Cheema, H.Chen, J. H.Chen, X.Chen, M.Cheng, K.Chervenkoff, J.Cheskes, L.Cheung, F.Chew, L. S.Chew, L.Chhabra, A.Chhina, C.Chilima, C. P.Chillarge, G.Chilvers, N. J.Chin, H.Chin, R.Chisholm, E. G.Chitnis, A. R.Chiu, S. M.Chong, B. F.Chong, J.Choo, K. P.Chrastek, D.Chua, E. Y.Chung, A.Claireaux, H. A.Clark, I. J.Clarke, A. K.Cleere, J.Clement, K. D.Clesham, K.Coates, A.Cody, A.Cody, N.Coffey, D.Coffey, C. J.Coffin, J.Cole, S. J.Collier, H.Collins, A.Collins, D.Collinson, S.Cooper, G. E.Cooper, D.Copley, H. C.Copley, P. C.Cornish, E.Cotton, A.Coulson, R.Cox, S. E.Craig, A. R.Craig, E.Craig-McQuaide, A.Crewdson, J. A.Croall, A.Crozier, L.Cullen, C.Cullen, S.Culleton, G.Cumber, E.Cumber, E. M.Cumming, S.Cundy, O. J.Cunha, P.Curran, A.Cuthbert, G.Cymes, W.Daoub, A.Darr, S.Das, M.Datta, U.Davies, N.Davies, J.Davies, J. E.Davies, K.Davis-Hall, M.Dawar, R.Dawson, P. M.de Bernier, G. L.Deall, C.Dean, R.Dean, S.Dean, W.Dear, K.Deas, G.Debenham, R.Deekonda, P.Delport, A.Demetri, A. M.Dennis, Y. F.Dennis, R.Derbyshire, L.Devabalan, Y.Devlin, E.Dewdney, C. J.Dhanji, A.Dhar, M.Dhutia, A. J.Diaper, C.Dickson, J.Din, W.Dindyal, S.Dinsmore, L.Doan, L.Dobson, J.Dogra, T.Doherty, C.Dolaghan, M.Dolbec, K. S.Dorman, C.Drake, T. M.Drislane, C.Dube, P.Duffy, A.Duke, K.Duncumb, J. W.Dunn, C. E.Durr, A.Durrani, B.Dutt, S.Dyal, A. R.Dynes, K.Edison, M. A.Edozie, F.Egan, R. J.Egerton, C.Elangovan, V.Elf, D.Elkawafi, M.Elliott, L. E.Elseedawy, M.Empey, J.English, W.Entwisle, J. H.Eparh, K.Eragat, M.Eraifej, J.Esteve, L.Farmer, J. D.Fautz, T.Favero, N.Fawaz, A. S.Fergurson, P.Fern, J.Filby, J. J.Filipescu, T.Fitzgerald, J. E.FitzPatrick, D.Fleck, R.Fletcher, L.Fong, J.Forrest, P. R.Forte, B.Foster, N. L.Francescon, C. T.Frank, A. L.Fung, T. M. P.Gabriel, J.Gaffney, S.Galloway, E.Gandhi, K.Gardiner, N.Gardner, E.Gardner, H.Gatfield, W. A.Gauntlett, L.Gentry, S.George, D.Geraghty, J. M.Ghaffar, A.Gilbert, H.Giles, J. E.Gill, P.Gill, C. K.Girling, C.Glasbey, J. C.Glover, T. E.Goh, B.Goh, R. W.Gohil, K.Gokani, S.Gold, D.Golding, D. M.Goldsmith, T.Goodier, R.Goradia, H.Gouda, P.Gouldthrope, C.Govinden, S.Graham, C. J.Gratton, R.Gray, L.Greenhalgh, A. D.Greig, R. J.Griffin, E. J.Grossart, C. M.Grundy, L.Gulati, J.Gundogan, B.Gupta, V.Gwozdz, A. M.Siddiqui, Z. H.Hague, A.Hameed, M.Hanrahan, M.Haq, H.Harbhajan Singh, G. S.Hardie, J.Harding, F.Hardy, M. R.Harries, P.Harris, R. T.Harris, L. N.Harrison, E. M.Harrison, P. L. M.Hartley, J.Hartley, S.Harvey, J.Hassan, S.Hayat, M.Hayat, U.Hayes, J. D. B.He, A.Healy, L.Heathcote, E.Heer, R. S.Heminway, R.Henderson, I.Henderson, L. A.Henderson, C.Heneghan, H.Henson, A. D.Heppenstall-Harris, G.Herron, J.Heskin, J.Hester, E.Hewitt, C. M.Heywood, E. G.Hibberd, A.Hickling, S. L.Higgins, A.Higgs, L.Hill, A.Hindle Fisher, I.Hirani, S.Hirst, F.Hitchen, N.Ho, W.Ho, S.Hoban, K. A.Holliday, R. B. S.Holloway, C.Holmes, C.Holmes, M. J. V.Holton, P.Holyoak, H.Horne, L.Horst, C.Horth, D.Hoskins, T. C.Howells, L.Hu, L.Huang, H. C.Hudson-Phillips, S.Hughes, F.Hughes, B. A.Hughes, R. K.Hulley, K.Hung, G.Hurst, P. C.Husnoo, S. B.Hussain, N.Hussain, O.Ibrahim, I.Ibrahim, A.Ingham, R.Ingram, E.Iqbal, S.Iqbal, A.Isaac, A.Jackson, H. R.Jackson, S.Jacob, L.Jafree, D. J.Jaitley, A.Jalota, P.Jamal, N.Jathanna, N.Jawad, A. S.Jayakody, N.Jenkin, S. L.Jenvey, C.Jewell, P. D.Jhala, H.Jindal, A.Johnston, A.Johnston, J.Johnstone, M.Jordan, H. E. M.Joshi, K. R.Joshi, D.Joyce, H. L.Joyner, C.Jubainville, C. L.Jull, P.Kadicheeni, M.Kahar, A.Kalra, N.Kanabar, S.Kane, T.Karia, M.Karia, P.Karsan, R. B.Karunakaran, P.Kaushal, A.Kazmi, Z.Keane, P.Keane, C. P.Keane, N.Kee, J. Y.Keeling, R. E.Keelty, N.Keevil, H.Kelly, M.Kelly, M. E.Kelly, N.Kennedy, E. D.Kennedy, H. R.Kerai, A.Kerr, A. L.Khajuria, A.Khalid, H.Khan, T.Khan, M.Khan, S.Khan, U.Khan, A.Khangura, J.Khanijau, R.Khatri, C.Khattak, M.Khetarpal, A. A.Khokhar, H. A.Khonat, Z.Khonsari, P.Kiff, R.Kim, S.Kim, J. W.Kimani, L.King, M.Kishore, A.Kisyov, I.Kitt, H.Knight, C. L.Kong, C. Y.Kong, C.Kosasih, S. R.Koshy, R. M.Kotecha, D.Koumpa, F.Kow, K.Koysombat, K.Kreibich, A.Kretzmer, L.Kumar, A. N.Kumaran, G.Kwan, M. L.Kwang, P.Lakhani, M.Lakhani, S. M.Lakshmipathy, G.Lalor, P.Lamont, J.Lankage, C. M.Lavery, J.Lazenby, D.Ledsam, A.Lee, A. H. Y.Lee, S.Lees, D. M.Lek, C.Leong, S.Leslie, K. E.Leung, W.Lewis, T.Li, N.Li, M. M.Liew, Y.Liew, W.Lim, K.Lim, J.Lim, D.Lim, A. E.Lim, S. J.Lim, S.Lim, E.Linton, A.Liu, S.Liu, C.Livesey, A.Lo, T.Lockey, J. W.Logan, A. E.Loke, W.Long, F.Lopes, S.Lotfallah, A.Lou, C. N.Loughran, D.Loveday, J.Low, J. Y. L.Lu, Q.Lua Boon Xuan, J.de Carvalho, J. LucasLuhishi, A.Luk, C. Y.Lunawat, S.Lwin, K. N.Lykoudis, P. M.Lynch, A. S.Lynne, S.Lyons, R.Maamari, R.MacAskill, A.MacDonald, J.Mackin, S.Maclennan, D.Mah, J.Mahboob, S.Maheswaran, Y.Mahmood, J.Majid, S.Major, C.Malaj, M.Malik, A.Mallick, S.Malys, M. K.Manson, R.Mansoor, S.Maple, N.Marchal, S. T.Markham, R. M.Marsden, M.Marsh, A.Marshall, D. C.Martin, A. L.Martin, R.Maru, D.Mason, J. D.Masood, M.Mastan, A.Matheson, J.Matthams, J.Matthews, B. W.Matthews, J. H.Maxwell-Armstrong, C.Mazan, K.Mazumdar, E.McAleer, S.McAleer, E.McAllister, R.McAuley, D.McBride, A.McCabe, G.McCance, E.McCann, M.McClymont, L. F.McCormack, D. R.McCrann, C.McDowell, M.McEnhill, P. M.McFarlane, H.McGalliard, R. J.McGarrigle, C.McGarvie, S.Mcgenity, C.McGowan, C.McGrath, A.McGregor, R. J.McIntyre, C. J.Mckean, E.McKelvey, L. L.McKerr, C. N.McKevitt, K. L.McLaughin, C.McLean, R. C.McLure, S. W.McMenamin, M.McMullan, R.McNamee, L.McRobbie, H. D.Meek, J.Mehdi, A.Mehta, J. K.Menon, A.Mian, A.Mills, E. D.Mills, M.Mills, H.Milne, S.Minhas, M.Miranda, B. H.Mirdavoudi, V.Mirza, M.Mishra, A.Mistry, S.Mistry, B. D.Mitchell, H.Mitha, N.Mithrakumar, P.Mitrasinovic, S.Mittapalli, D.Mogan, Y. P.Mohamud, M.Mohan, M.Mohan, K.Mohite, A.Momoh, Z.Moody, N.Moon, R. D. C.Moradzadeh, J.Morgan, F.Morgan, C.Morley, R.Morris, F.Morris, S.Morrison, P.Morrison, C. J.Mortimer, A.Murkin, C.Murphy, L.Murray, S. E.Murtaza, A.Mushtaq, J.Nachiappan, R.Nadanakumaran, K.Naqib, S.Narain, A.Naran, P.Narang, Y.Narayan, P.Narramore, R.Narwani, V.Navayogaarajah, V.Naveed, H.Nayee, H.Nehikhare, I.Nelaj, S.Neo, Y. N.Neophytou, C.Nepogodiev, D.Nesargikar, P. N.Ng, K.Ng, J. C. K.Ng, G. S.Ng, J. Q.Ng, A. Y. L.Ng, S.Ng, L.Nicholls, K.Nixon, G.Norris, J. M.North, A. S.Norton, J.Ntala, C.O’Bryan, M.O’Carroll, O.O’Connell, C.O’Connor, A.O’Connor, S.O’Flynn, L. D.O’Kane, A.O’Loughlin, R. A.O’Neill, S.O’Neill, E. M.O’Reilly, D.O’Sullivan, D. A.O’Sullivan, K.Obute, R. D.Odeleye, A.Omar, A.Omara, S.Omer, H. M.Ong, K. K.Oremule, B.Osei-Kuffour, D.Osman, S.Owasil, R.Owczarek, S.Williams, R. P.Paine, H. R.Pal, S.Palkhi, E.Palmer, C.Pandey, A.Pandey, G.Paraoan, V.Park, J. H.Parker, O.Parker, J.Parkin, J.Parsons, S.Parthiban, S.Patel, P.Patel, M.Patel, T.Patel, S.Patel, N.Patel, J. 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T.Robinson, M.Robinson, C.Robson, J.Rocke, A. S.Rogers, J. E.Rogers, S.Rojoa, D.Rookes, C. W.Rosen O’Sullivan, H.Ross, T.Ross, H.Rothwell, L.Roy, C. S. D.Ruiz, E. M.Russell, G.Ryan, M.Sabine, L. M.Sagar, R.Sagmeister, M.Sahathevan, A.Sait, M. S.Sajjad, U.Salam, G. J.Sale, T.Salem, M.Salih, A. E.Salmon, D.Sanders, J. A.Sandhu, K. K.Sandhu, S.Sangal, P.Sarvanandan, T.Sarwar, S.Sasapu, K.Satterthwaite, L.Schulz, T. M.Scotcher, S. E.Seager, E.Seedat, M.Segall, E.Sellathurai, J.Selvachandran, H.Semana, A. D.Semnani, S. A.Semple, E.Seneviratne, N.Sethi, R. K.Shafi, A. M. A.Shafiq, N. M.Shah, A.Shah, J. P.Shah, R.Shah, S.Shaheen, H.Shahid, S.Shahidi, S.Shakweh, E.Shanahan, D.Sharifpour, M.Shatkar, V.Shaunak, R.Sheldon, A.Shepherd, R.Shepherd, P.Sherif, M. A.Sherliker, G. X. J.Sheth, S.Shoa, M.Shufflebotham, H.Shuker, B. A.Shukla, A.Shumon, S.Shurovi, B. N.Shuttleworth, R. H.Siddiqui, M.Sii, S.Sim, N. K.Sim, P.Sim, D.Simpson, R.Simpson, A.Singagireson, S.Singh, B.Singh, K.Singh, R.Singh, S.Sinha, Y.Sirakaya, M.Sitta, O.Slade, R.Smith, N.Smith, D. N. E.Smith, A. C. D.Sng, S.Soo, Y. H.Soon, W. C.Sorah, T.Spence, O.Spencer, T.Springford, L. R.Sreh, A.Srikantharajah, M.Sritharan, P.Stanger, S. A.Stanley, G. H.Stather, P. W.Steel, M.Stein, J.Stevens, S.Stewart, G. E.Stezaker, S.Stoddart, M. T.Stokes, S.Stone, E. J.Stott, G. D.Strange, E.Street, A. N.Sukkari, M.Sukumar, S.Suleman, Y. N.Sullivan, J. A. L.Sun, E.Sundar-Singh, M.Suresh, S.Suresh, R. S.Syeed, J. A.Sykes, M. C.Szczap, A.Tahir, M.Tahmina, A.Tai, A.Talukdar, S. S.Tan, Y. H.Tan, R.Tan, E. T.Tan, D.Tan, Y.Tan, S.Tan, E. S. M.Tay, A. Y.Tayeh, S.Tear, A. K.Telfer, R.Teng, V.Teoh, P. J.Thacoor, A.Thakker, C. E.Thakur, H.Tharakan, R. G.Tharmachandirar, T.Theodoreson, M. D.Theodoropoulou, K.Thethi, R.Thevathasan, A. A.Thirumal, V.Thomas, G.Thomas, D.Thompson, O. D.Thompson, J. D.Tilston, T. W.Toale, C.Toh, C.Toner, E.Tongo, F.Tonkins, M.Topham, C.Torlot, G. E.Torrance, H. D.Trail, M.Traynor, B. P.Trecarten, S.Trimble, A.Trist, A. J.Tsui, A. Y.Tung, L.Turaga, S.Turley, H.Turnbull, J. A.Turner, L.Turner, M.Turner, E. J. H.Turner, J.Ungcharoen, N.Uppal, E.Valli, A.Vanmali, P.Varley, R.Varma, R. K.Varma, D.Varma, N.Vaughan, R.Venn, M.Ventre, C. M.Verma, K.Verma, S.Vernon, O. K.Vithanage, N. A.Vivekanantham, S.Wadanamby, S.Waldron, R. M.Walford, R. A.Wali, A.Wall, C.Walsh, S. L.Wan, J. C.Wang, S.Wang, A.Ward, N.Ward, T.Ward, A. E.Warren, N.Warwick, H. L.Watson, N.Watson, R. P.Weaver, R.Webb, E.Weinberg, D.Wells, M.Weston, C.Wetherall, N.Whacha, C.Whatling, E. A.Whewell, H.White, A.White, C. J.White, U.Whitehurst, K.Whitham, R. D. J.Whittingham, H.Wijesekera, M.Wild, J. R. L.Wilkinson, D.Williams, M.Williams, M. R.Williams, P.Wills, J.Wilson, H. C. P.Wilson, H.Wilson, R.Wiltshire, J. J.Winarski, A.Wing, V. C.Wingfield, L. R.Winslow, F.Woin, E.Wong, V.Wong, E.Wood, A. D.Woodcock, N.Woodward, H.Woon, E.Wright, A.Wright, E. V.Wye, J.Wylam, D.Wylie, J.Wynell-Mayow, W. M.Xiao, C.Xu, G. X.Xylas, D.Yan, A.Yang, T.Yates, J. A.Yener, A.Yim, N.Yoganathan, S.Yong, C. S.Yong, N.Yousif, A.Yow, L.Yuen, R.Zegeye, M. I.Zhao, J.Ziff, O.Ziprin, P.Zuhair, M.STARSurg Collaborative
Source
World Journal of Surgery: Official Journal of the International Society of Surgery/Société Internationale de Chirurgie. January 2017 41(1):47-55
Subject
Language
English
ISSN
0364-2313
1432-2323
Abstract
Background: Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery.Methods:Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals.Results:From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560).Conclusions:Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery.