학술논문
Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts
Document Type
Original Paper
Author
Hvidtfeldt, Ulla Arthur; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jørgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Katsouyanni, Klea; Ketzel, Matthias; Leander, Karin; Magnusson, Patrik K. E.; Nagel, Gabriele; Pershagen, Göran; Rizzuto, Debora; Samoli, Evangelia; So, Rina; Stafoggia, Massimo; Tjønneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Zhang, Jiawei; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole
Source
British Journal of Cancer. 129(4):656-664
Subject
Language
English
ISSN
0007-0920
1532-1827
1532-1827
Abstract
Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown.Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2 ), fine particles (PM2.5 ), black carbon (BC), ozone (O3 ) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2 , 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5 , 1.10 (0.97, 1.25) per 0.5 10−5 m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3 .Conclusions: We observed indications of an association between exposure to NO2 , PM2.5 , and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.