학술논문
Single-cell multiomic analyses sheds light on mitochondrial mutational selection
Document Type
Brief Communication
Source
Nature Genetics. 55(7):1083-1085
Subject
Language
English
ISSN
1061-4036
1546-1718
1546-1718
Abstract
Single large-scale mitochondrial DNA deletions cause a spectrum of disease with differing severities and tissue expressivity. Quantification of single-cell deletion levels with multi-modal cellular readouts provides insights into hematopoietic cell fate and disease manifestation.