부산대학교 도서관

To investigate the effects of quercetin on the expression of microRNA-155 (miR-155) and the functions of lipopolysaccharide (LPS)-treated extravillous trophoblast cells. Cell apoptosis significantly increased and invasion cell number and wound healing rate significantly decreased in the model group compared with the NC group (P < 0.001). Quercetin supplement significantly improved the cell apoptosis rate, invasion cell number and wound healing rate (P < 0.05, respectively) compared with the model group. However, after miR-155 transfection, the cell apoptosis rate, invasion cell number and wound healing rate were similar to those in the model group. RT-qPCR and WB assays showed that quercetin decreased miR-155 gene expression and p-JunB and p-FosB protein expression levels. Quercetin pretreatment can protect extravillous trophoblast cells from apoptosis and loss of migratory and invasive abilities through down-regulating the expression of miR-155, which may be a mechanism that inhibits the development of preeclampsia by in vitro study.