학술논문
Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population
Document Type
article
Source
Brazilian Journal of Medical and Biological Research. January 2017 50(7)
Subject
Language
English
ISSN
0100-879X
Abstract
Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripheral blood samples from individuals with different ethnic backgrounds. The t(14;18) translocation was found in 45 of 85 White individuals (52.94%); in 57 of 72 Black individuals (79.17%); and in 68 of 70 individuals (97.14%) of Japanese-descent. In conclusion, the frequency of the t(14;18) translocation in the Brazilian population varies according to the ethnic background.