학술논문
Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019
Document Type
article
Author
Koh, Benjamin; Tan, Darren Jun Hao; Ng, Cheng Han; Fu, Clarissa Elysia; Lim, Wen Hui; Zeng, Rebecca Wenling; Yong, Jie Ning; Koh, Jia Hong; Syn, Nicholas; Meng, Wang; Wijarnpreecha, Karn; Liu, Ken; Chong, Choon Seng; Muthiah, Mark; Luu, Hung N; Vogel, Arndt; Singh, Siddharth; Yeoh, Khay Guan; Loomba, Rohit; Huang, Daniel Q
Source
JAMA Network Open. 6(8)
Subject
Language
Abstract
ImportanceEmerging data suggest that the incidence of early-onset cancers, defined as cancers diagnosed in people younger than 50 years, is increasing, but updated data are limited.ObjectiveTo characterize the patterns in the incidence of early-onset cancers in the US from 2010 to 2019 and provide granular data on the cancers with the fastest-growing incidence rates.Design, setting, and participantsThis population-based cohort study analyzed data from 17 National Cancer Institute Surveillance, Epidemiology, and End Results registries from January 1, 2010, to December 31, 2019. Age-standardized incidence rates per 100 000 people were extracted for early-onset cancers, with rates age adjusted to the US standard population. A total of 562 145 patients with early-onset cancer between 2010 and 2019 were identified and included. Data were analyzed from October 16, 2022, to May 23, 2023.Main outcomes and measuresPrimary outcomes were incidence rates and descriptive epidemiological data for people younger than 50 years with cancer. The annual percentage change (APC) of the age-standardized incidence rate was estimated using the Joinpoint regression program.ResultsAmong 562 145 patients (324 138 [57.7%] aged 40-49 years; 351 120 [62.5%] female) with early-onset cancer, 4565 (0.8%) were American Indian or Alaska Native, 54 876 (9.8%) were Asian or Pacific Islander, 61 048 (10.9%) were Black, 118 099 (21.0%) were Hispanic, 314 610 (56.0%) were White, and 8947 (1.6%) were of unknown race and/or ethnicity. From 2010 to 2019, the age-standardized incidence rate of early-onset cancers increased overall (APC, 0.28%; 95% CI, 0.09%-0.47%; P = .01) and in female individuals (APC, 0.67%; 95% CI, 0.39%-0.94%; P = .001) but decreased in male individuals (APC, -0.37%; 95% CI, -0.51% to -0.22%; P