학술논문
Macular spatial distribution of preserved autofluorescence in patients with choroideremia
Document Type
article
Author
Hariri, Amir H; Ip, Michael S; Girach, Aniz; Lam, Byron L; Fischer, M Dominik; Sankila, Eeva-Marja; Pennesi, Mark Edward; Holz, Frank G; Maclaren, Robert E; Birch, David G; Hoyng, Carel B; MacDonald, Ian M; Black, Graeme C; Tsang, Stephen H; Bressler, Neil M; Stepien, Kimberly E; Larsen, Michael; Gorin, Michael B; Meunier, Isabelle; Webster, Andrew R; Sadda, SriniVas
Source
British Journal of Ophthalmology. 103(7)
Subject
Language
Abstract
Background/aimsTo better understand the pattern of degeneration progression in cases with choroideremia.MethodsA cohort of genotypically confirmed choroideremia cases who underwent optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging was studied. Using HEYEX review software, the foveal centre was marked on FAF images under guidance of corresponding OCT images, followed by application of an ETDRS grid. The boundaries of preserved autofluorescence (AF) were manually segmented in each individual ETDRS subfield. The regional distribution of preserved AF was assessed by comparing its area among the various subfields.ResultsA total of 168 eyes from 84 choroideremia cases were enrolled. There was a statistically significant difference in the amount of preserved AF area between inner subfields as determined by one-way analysis of variance (F (3,668)=9.997, p