학술논문

Genome-wide association study identifies 30 loci associated with bipolar disorder
Document Type
article
Author
Stahl, Eli ABreen, GeromeForstner, Andreas JMcQuillin, AndrewRipke, StephanTrubetskoy, VassilyMattheisen, ManuelWang, YunpengColeman, Jonathan RIGaspar, Héléna Ade Leeuw, Christiaan ASteinberg, StacyPavlides, Jennifer M WhiteheadTrzaskowski, MaciejByrne, Enda MPers, Tune HHolmans, Peter ARichards, Alexander LAbbott, LiamAgerbo, EsbenAkil, HudaAlbani, DiegoAlliey-Rodriguez, NeyAls, Thomas DAnjorin, AdebayoAntilla, VerneriAwasthi, SwapnilBadner, Judith ABækvad-Hansen, MarieBarchas, Jack DBass, NicholasBauer, MichaelBelliveau, RichardBergen, Sarah EPedersen, Carsten BøckerBøen, ErlendBoks, Marco PBoocock, JamesBudde, MonikaBunney, WilliamBurmeister, MargitBybjerg-Grauholm, JonasByerley, WilliamCasas, MiquelCerrato, FeleciaCervantes, PabloChambert, KimberlyCharney, Alexander WChen, DanfengChurchhouse, ClaireClarke, Toni-KimCoryell, WilliamCraig, David WCruceanu, CristianaCurtis, DavidCzerski, Piotr MDale, Anders Mde Jong, SimoneDegenhardt, FranziskaDel-Favero, JurgenDePaulo, J RaymondDjurovic, SrdjanDobbyn, Amanda LDumont, AshleyElvsåshagen, TorbjørnEscott-Price, ValentinaFan, Chun ChiehFischer, Sascha BFlickinger, MatthewForoud, Tatiana MForty, LizFrank, JosefFraser, ChristineFreimer, Nelson BFrisén, LouiseGade, KatrinGage, DianeGarnham, JulieGiambartolomei, ClaudiaPedersen, Marianne GiørtzGoldstein, JaquelineGordon, Scott DGordon-Smith, KatherineGreen, Elaine KGreen, Melissa JGreenwood, Tiffany AGrove, JakobGuan, WeihuaGuzman-Parra, JoséHamshere, Marian LHautzinger, MartinHeilbronner, UrsHerms, StefanHipolito, MariaHoffmann, PerHolland, DominicHuckins, LauraJamain, StéphaneJohnson, Jessica SJuréus, Anders
Source
Nature Genetics. 51(5)
Subject
Biological Sciences
Genetics
Serious Mental Illness
Mental Health
Human Genome
Brain Disorders
Schizophrenia
Aetiology
2.1 Biological and endogenous factors
Mental health
Bipolar Disorder
Case-Control Studies
Depressive Disorder
Major
Female
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Polymorphism
Single Nucleotide
Psychotic Disorders
Systems Biology
eQTLGen Consortium
BIOS Consortium
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Medical and Health Sciences
Developmental Biology
Agricultural biotechnology
Bioinformatics and computational biology
Language
Abstract
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P