학술논문
Stable Colloidal Drug Aggregates Catch and Release Active Enzymes
Document Type
article
Author
Source
ACS Chemical Biology. 11(4)
Subject
Language
Abstract
Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the coaggregation of seven molecules chosen because they had been previously intensely studied as colloidal aggregators, coformulating them with bis-azo dyes. The coformulation reduced colloid sizes to