학술논문
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
Document Type
article
Author
Li, Shaobo; Spitz, Natalia; Ghantous, Akram; Abrishamcar, Sarina; Reimann, Brigitte; Marques, Irene; Silver, Matt J; Aguilar-Lacasaña, Sofía; Kitaba, Negusse; Rezwan, Faisal I; Röder, Stefan; Sirignano, Lea; Tuhkanen, Johanna; Mancano, Giulia; Sharp, Gemma C; Metayer, Catherine; Morimoto, Libby; Stein, Dan J; Zar, Heather J; Alfano, Rossella; Nawrot, Tim; Wang, Congrong; Kajantie, Eero; Keikkala, Elina; Mustaniemi, Sanna; Ronkainen, Justiina; Sebert, Sylvain; Silva, Wnurinham; Vääräsmäki, Marja; Jaddoe, Vincent WV; Bernstein, Robin M; Prentice, Andrew M; Cosin-Tomas, Marta; Dwyer, Terence; Håberg, Siri Eldevik; Herceg, Zdenko; Magnus, Maria C; Munthe-Kaas, Monica Cheng; Page, Christian M; Völker, Maja; Gilles, Maria; Send, Tabea; Witt, Stephanie; Zillich, Lea; Gagliardi, Luigi; Richiardi, Lorenzo; Czamara, Darina; Räikkönen, Katri; Chatzi, Lida; Vafeiadi, Marina; Arshad, S Hasan; Ewart, Susan; Plusquin, Michelle; Felix, Janine F; Moore, Sophie E; Vrijheid, Martine; Holloway, John W; Karmaus, Wilfried; Herberth, Gunda; Zenclussen, Ana; Streit, Fabian; Lahti, Jari; Hüls, Anke; Hoang, Thanh T; London, Stephanie J; Wiemels, Joseph L
Source
Communications Biology. 7(1)
Subject
Language
Abstract
Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P