학술논문
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors
Document Type
article
Author
Garg, Shreeya; Kreutzfeld, Oriana; Chelebieva, Sevil; Tumwebaze, Patrick K; Byaruhanga, Oswald; Okitwi, Martin; Orena, Stephen; Katairo, Thomas; Nsobya, Samuel L; Conrad, Melissa D; Aydemir, Ozkan; Legac, Jennifer; Gould, Alexandra E; Bayles, Brett R; Bailey, Jeffrey A; Duffey, Maelle; Lin, Gang; Kirkman, Laura A; Cooper, Roland A; Rosenthal, Philip J
Source
Antimicrobial Agents and Chemotherapy. 66(10)
Subject
Language
Abstract
The proteasome is a promising target for antimalarial chemotherapy. We assessed ex vivo susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven proteasome inhibitors: two asparagine ethylenediamines, two macrocyclic peptides, and three peptide boronates; five had median IC50 values