학술논문

Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803
Document Type
article
Source
Journal of the National Cancer Institute. 104(22)
Subject
Nutrition
Digestive Diseases
Cancer
Colo-Rectal Cancer
Clinical Research
Prevention
Good Health and Well Being
Adult
Aged
Blood Glucose
Body Mass Index
Colonic Neoplasms
Dietary Carbohydrates
Dietary Sucrose
Disease-Free Survival
Energy Intake
Female
Follow-Up Studies
Fructose
Glycemic Index
Humans
Male
Middle Aged
Neoplasm Recurrence
Local
Neoplasm Staging
Odds Ratio
Proportional Hazards Models
Prospective Studies
Randomized Controlled Trials as Topic
Risk Factors
Survival Analysis
United States
Oncology and Carcinogenesis
Oncology & Carcinogenesis
Language
Abstract
BackgroundThe influence of glycemic load and related measures on survival among colon cancer patients remains largely unknown.MethodsWe conducted a prospective, observational study of 1011 stage III colon cancer patients reporting dietary intake during and 6 months after participation in an adjuvant chemotherapy trial. We examined the influence of glycemic load, glycemic index, fructose, and carbohydrate intakes on cancer recurrence and mortality using Cox proportional hazards regression; all tests of statistical significance were two-sided.ResultsStage III colon cancer patients in the highest quintile of dietary glycemic load experienced an adjusted hazard ratio (HR) for disease-free survival of 1.79 (95% confidence interval [CI] = 1.29 to 2.48), compared with those in the lowest quintile (P (trend) across quintiles