학술논문
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
Document Type
article
Author
Wang, Xin; Xie, Hong; Chen, Tian; Cotton, Andrew S; Salminen, Lauren E; Logue, Mark W; Clarke-Rubright, Emily K; Wall, John; Dennis, Emily L; O’Leary, Brian M; Abdallah, Chadi G; Andrew, Elpiniki; Baugh, Lee A; Bomyea, Jessica; Bruce, Steven E; Bryant, Richard; Choi, Kyle; Daniels, Judith K; Davenport, Nicholas D; Davidson, Richard J; DeBellis, Michael; deRoon-Cassini, Terri; Disner, Seth G; Fani, Negar; Fercho, Kelene A; Fitzgerald, Jacklynn; Forster, Gina L; Frijling, Jessie L; Geuze, Elbert; Gomaa, Hassaan; Gordon, Evan M; Grupe, Dan; Harpaz-Rotem, Ilan; Haswell, Courtney C; Herzog, Julia I; Hofmann, David; Hollifield, Michael; Hosseini, Bobak; Hudson, Anna R; Ipser, Jonathan; Jahanshad, Neda; Jovanovic, Tanja; Kaufman, Milissa L; King, Anthony P; Koch, Saskia BJ; Koerte, Inga K; Korgaonkar, Mayuresh S; Krystal, John H; Larson, Christine; Lebois, Lauren AM; Levy, Ifat; Li, Gen; Magnotta, Vincent A; Manthey, Antje; May, Geoffrey; McLaughlin, Katie A; Mueller, Sven C; Nawijn, Laura; Nelson, Steven M; Neria, Yuval; Nitschke, Jack B; Olff, Miranda; Olson, Elizabeth A; Peverill, Matthew; Phan, K Luan; Rashid, Faisal M; Ressler, Kerry; Rosso, Isabelle M; Sambrook, Kelly; Schmahl, Christian; Shenton, Martha E; Sierk, Anika; Simons, Jeffrey S; Simons, Raluca M; Sponheim, Scott R; Stein, Murray B; Stein, Dan J; Stevens, Jennifer S; Straube, Thomas; Suarez-Jimenez, Benjamin; Tamburrino, Marijo; Thomopoulos, Sophia I; van der Wee, Nic JA; van der Werff, Steven JA; van Erp, Theo GM; van Rooij, Sanne JH; van Zuiden, Mirjam; Varkevisser, Tim; Veltman, Dick J; Vermeiren, Robert RJM; Walter, Henrik; Wang, Li; Zhu, Ye; Zhu, Xi; Thompson, Paul M; Morey, Rajendra A; Liberzon, Israel
Source
Molecular Psychiatry. 26(8)
Subject
Language
Abstract
Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = -0.111 to -0.068, FDR corrected P values