학술논문

Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment
Document Type
article
Author
Georghiou, Sophia BRodwell, Timothy CKorobitsyn, AlexeiAbbadi, Said HAjbani, KanchanAlffenaar, Jan-WillemAlland, DavidAlvarez, NatalyAndres, SönkeArdizzoni, ElisaAubry, AlexandraBaldan, RossellaBallif, MarieBarilar, IvanBöttger, Erik CChakravorty, SoumiteshClaxton, Pauline MCirillo, Daniela MComas, IñakiCoulter, ChrisDenkinger, Claudia MDerendinger, BrigittaDesmond, Edward Pde Steenwinkel, Jurriaan EMDheda, KeertanDiacon, Andreas HDolinger, David LDooley, Kelly EEgger, MatthiasEhsani, SoudehFarhat, Maha RFattorini, LanfrancoFinci, IrisLe Ray, Laure FournierFurió, VictoriaGroenheit, RamonaGumbo, TawandaHeysell, Scott KHillemann, DorisHoffmann, HaraldHsueh, Po-RenHu, YiHuang, HairongHussain, AlamdarIsmail, FarzanaIzumi, KiyohikoJagielski, TomaszJohnson, John LKambli, PritiKaniga, KonéKarunaratne, GHR ErangaSharma, Meenu KaushalKeller, Peter MKelly, Ellis CKholina, MargaritaKohli, MikashmiKranzer, KatharinaLaurenson, Ian FLimberis, JasonLin, S-Y GraceLiu, YonggeLópez-Gavín, AlexandreLyander, AnnaMachado, DianaMartinez, ElenaMasood, FaisalMitarai, SatoshiMvelase, Nomonde RNiemann, StefanNikolayevskyy, VladyslavMaurer, Florian PMerker, MatthiasMiotto, PaoloOmar, Shaheed VOtto-Knapp, RalfPalaci, MoisésGutiérrez, Juan José PalaciosPeacock, Sharon JPeloquin, Charles APerera, JenniferPierre-Audigier, CatherinePholwat, SupornPosey, James EPrammananan, TherdsakRigouts, LeenRobledo, JaimeRockwood, NeeshaRodrigues, CamillaSalfinger, MaxSchechter, Marcos CSeifert, MarvaSengstake, SarahShinnick, ThomasShubladze, NataliaSintchenko, VitaliSirgel, FrederickSomasundaram, SulochanaSterling, Timothy RSpitaleri, AndreaStreicher, Elizabeth
Source
European Respiratory Journal. 59(4)
Subject
Medical Microbiology
Biomedical and Clinical Sciences
Clinical Sciences
Infectious Diseases
Biodefense
Antimicrobial Resistance
Prevention
Rare Diseases
Emerging Infectious Diseases
Tuberculosis
Clinical Research
Vaccine Related
Orphan Drug
5.1 Pharmaceuticals
Development of treatments and therapeutic interventions
Infection
Good Health and Well Being
Antitubercular Agents
Drug Resistance
Bacterial
Drug Resistance
Multiple
Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Tuberculosis
Multidrug-Resistant
Antimycobacterial Susceptibility Testing Group
Medical and Health Sciences
Respiratory System
Cardiovascular medicine and haematology
Language
Abstract
Inappropriately high breakpoints have resulted in systematic false-susceptible AST results to anti-TB drugs. MIC, PK/PD and clinical outcome data should be combined when setting breakpoints to minimise the emergence and spread of antimicrobial resistance. https://bit.ly/3i43wb6