학술논문
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
Document Type
article
Author
Meddens, S Fleur W; de Vlaming, Ronald; Bowers, Peter; Burik, Casper AP; Linnér, Richard Karlsson; Lee, Chanwook; Okbay, Aysu; Turley, Patrick; Rietveld, Cornelius A; Fontana, Mark Alan; Ghanbari, Mohsen; Imamura, Fumiaki; McMahon, George; van der Most, Peter J; Voortman, Trudy; Wade, Kaitlin H; Anderson, Emma L; Braun, Kim VE; Emmett, Pauline M; Esko, Tonũ; Gonzalez, Juan R; Kiefte-de Jong, Jessica C; Langenberg, Claudia; Luan, Jian’an; Muka, Taulant; Ring, Susan; Rivadeneira, Fernando; Snieder, Harold; van Rooij, Frank JA; Wolffenbuttel, Bruce HR; Smith, George Davey; Franco, Oscar H; Forouhi, Nita G; Ikram, M Arfan; Uitterlinden, Andre G; van Vliet-Ostaptchouk, Jana V; Wareham, Nick J; Cesarini, David; Harden, K Paige; Lee, James J; Benjamin, Daniel J; Chow, Carson C; Koellinger, Philipp D
Source
Molecular Psychiatry. 26(6)
Subject
Language
Abstract
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P