학술논문
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.
Document Type
article
Author
Groenewold, Nynke; Bas-Hoogendam, Janna; Amod, Alyssa; Laansma, Max; Van Velzen, Laura; Aghajani, Moji; Hilbert, Kevin; Oh, Hyuntaek; Salas, Ramiro; Jackowski, Andrea; Pan, Pedro; Salum, Giovanni; Blair, James; Blair, Karina; Hirsch, Joy; Pantazatos, Spiro; Schneier, Franklin; Talati, Ardesheer; Roelofs, Karin; Volman, Inge; Blanco-Hinojo, Laura; Cardoner, Narcís; Pujol, Jesus; Beesdo-Baum, Katja; Ching, Christopher; Thomopoulos, Sophia; Jansen, Andreas; Kircher, Tilo; Krug, Axel; Nenadić, Igor; Stein, Frederike; Dannlowski, Udo; Grotegerd, Dominik; Lemke, Hannah; Meinert, Susanne; Winter, Alexandra; Erb, Michael; Kreifelts, Benjamin; Gong, Qiyong; Lui, Su; Zhu, Fei; Mwangi, Benson; Soares, Jair; Wu, Mon-Ju; Bayram, Ali; Canli, Mesut; Tükel, Raşit; Westenberg, P; Heeren, Alexandre; Cremers, Henk; Hofmann, David; Straube, Thomas; Doruyter, Alexander; Lochner, Christine; Peterburs, Jutta; Van Tol, Marie-José; Gur, Raquel; Kaczkurkin, Antonia; Larsen, Bart; Satterthwaite, Theodore; Filippi, Courtney; Gold, Andrea; Harrewijn, Anita; Zugman, André; Bülow, Robin; Grabe, Hans; Völzke, Henry; Wittfeld, Katharina; Böhnlein, Joscha; Dohm, Katharina; Kugel, Harald; Schrammen, Elisabeth; Zwanzger, Peter; Leehr, Elisabeth; Sindermann, Lisa; Ball, Tali; Fonzo, Gregory; Paulus, Martin; Stein, Murray; Klumpp, Heide; Phan, K; Furmark, Tomas; Månsson, Kristoffer; Manzouri, Amirhossein; Avery, Suzanne; Blackford, Jennifer; Clauss, Jacqueline; Feola, Brandee; Harper, Jennifer; Sylvester, Chad; Lueken, Ulrike; Veltman, Dick; Winkler, Anderson; Jahanshad, Neda; Pine, Daniel; Thompson, Paul; Stein, Dan; Van der Wee, Nic; Simmons, Alan
Source
Molecular Psychiatry. 28(3)
Subject
Language
Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, pFWE = 0.037; right: d = -0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, pFWE