학술논문
Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The Cocoa-Pad Pilot Randomized Clinical Trial
Document Type
article
Author
McDermott, Mary M; Criqui, Michael H; Domanchuk, Kathryn; Ferrucci, Luigi; Guralnik, Jack M; Kibbe, Melina R; Kosmac, Kate; Kramer, Christopher M; Leeuwenburgh, Christiaan; Li, Lingyu; Lloyd-Jones, Donald; Peterson, Charlotte A; Polonsky, Tamar S; Stein, James H; Sufit, Robert; Van Horn, Linda; Villarreal, Francisco; Zhang, Dongxue; Zhao, Lihui; Tian, Lu
Source
Circulation Research. 126(5)
Subject
Language
Abstract
RationaleCocoa and its major flavanol component, epicatechin, have therapeutic properties that may improve limb perfusion and increase calf muscle mitochondrial activity in people with lower extremity peripheral artery disease (PAD).ObjectiveIn a phase II randomized clinical trial, to assess whether 6 months of cocoa improved walking performance in people with PAD, compared with placebo.Methods and resultsSix-month double-blind, randomized clinical trial in which participants with PAD were randomized to either cocoa beverage versus placebo beverage. The cocoa beverage contained 15 g of cocoa and 75 mg of epicatechin daily. The identical appearing placebo contained neither cocoa nor epicatechin. The 2 primary outcomes were 6-month change in 6-minute walk distance measured 2.5 hours after a study beverage at 6-month follow-up and 24 hours after a study beverage at 6-month follow-up, respectively. A 1-sided P