학술논문
Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos
Document Type
article
Author
Zhang, Yuan; Elgart, Michael; Granot-Hershkovitz, Einat; Wang, Heming; Tarraf, Wassim; Ramos, Alberto R; Stickel, Ariana M; Zeng, Donglin; Garcia, Tanya P; Testai, Fernando D; Wassertheil-Smoller, Sylvia; Isasi, Carmen R; Daviglus, Martha L; Kaplan, Robert; Fornage, Myriam; DeCarli, Charles; Redline, Susan; González, Hector M; Sofer, Tamar
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Abstract
BackgroundSleep phenotypes have been reported to be associated with cognitive ageing outcomes. However, there is limited research using genetic variants as proxies for sleep traits to study their associations. We estimated associations between Polygenic Risk Scores (PRSs) for sleep duration, insomnia, daytime sleepiness, and obstructive sleep apnoea (OSA) and measures of cogntive ageing in Hispanic/Latino adults.MethodsWe used summary statistics from published genome-wide association studies to construct PRSs representing the genetic basis of each sleep trait, then we studied the association of the PRSs of the sleep phenotypes with cognitive outcomes in the Hispanic Community Healthy Study/Study of Latinos. The primary model adjusted for age, sex, study centre, and measures of genetic ancestry. Associations are highlighted if their p-value