학술논문

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials.
Document Type
article
Source
Cancer. 125(1)
Subject
Animals
Humans
Melanoma
Skin Neoplasms
Anticarcinogenic Agents
Radiation-Protective Agents
Chemoprevention
Female
Male
Clinical Trials
Phase III as Topic
Drug Repositioning
Drug Development
biomarkers
chemoprevention
human model systems
melanoma
natural products
Climate-Related Exposures and Conditions
Clinical Research
Clinical Trials and Supportive Activities
Prevention
Cancer
5.1 Pharmaceuticals
Prevention of disease and conditions
and promotion of well-being
Development of treatments and therapeutic interventions
3.3 Nutrition and chemoprevention
6.1 Pharmaceuticals
Evaluation of treatments and therapeutic interventions
Oncology and Carcinogenesis
Public Health and Health Services
Oncology & Carcinogenesis
Language
Abstract
Recent progress in the treatment of advanced melanoma has led to unprecedented improvements in overall survival and, as these new melanoma treatments have been developed and deployed in the clinic, much has been learned about the natural history of the disease. Now is the time to apply that knowledge toward the design and clinical evaluation of new chemoprevention agents. Melanoma chemoprevention has the potential to reduce dramatically both the morbidity and the high costs associated with treating patients who have metastatic disease. In this work, scientific and clinical melanoma experts from the national Melanoma Prevention Working Group, composed of National Cancer Trials Network investigators, discuss research aimed at discovering and developing (or repurposing) drugs and natural products for the prevention of melanoma and propose an updated pipeline for translating the most promising agents into the clinic. The mechanism of action, preclinical data, epidemiological evidence, and results from available clinical trials are discussed for each class of compounds. Selected keratinocyte carcinoma chemoprevention studies also are considered, and a rationale for their inclusion is presented. These data are summarized in a table that lists the type and level of evidence available for each class of agents. Also included in the discussion is an assessment of additional research necessary and the likelihood that a given compound may be a suitable candidate for a phase 3 clinical trial within the next 5 years.