학술논문
Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome
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article
Author
Niarchou, Maria; Chawner, Samuel JRA; Fiksinski, Ania; Vorstman, Jacob AS; Maeder, Johanna; Schneider, Maude; Eliez, Stephan; Armando, Marco; Pontillo, Maria; Vicari, Stefano; McDonald-McGinn, Donna M; Emanuel, Beverly S; Zackai, Elaine H; Bearden, Carrie E; Shashi, Vandana; Hooper, Stephen R; Owen, Michael J; Gur, Raquel E; Wray, Naomi R; van den Bree, Marianne BM; Thapar, Anita; Consortium, International 22q11 2 Deletion Syndrome Brain and Behavior
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Abstract
Individuals with 22q11.2 Deletion Syndrome (22q11.2DS) are at substantially heightened risk for psychosis. Thus, prevention and early intervention strategies that target the antecedents of psychosis in this high-risk group are a clinical priority. Attention Deficit Hyperactivity Disorder (ADHD) is one the most prevalent psychiatric disorders in children with 22q11.2DS, particularly the inattentive subtype. The aim of this study was to test the hypothesis that ADHD inattention symptoms predict later psychotic symptoms and/or psychotic disorder in those with 22q11.2DS. 250 children and adolescents with 22q11.2DS without psychotic symptoms at baseline took part in a longitudinal study. Assessments were performed using well-validated structured diagnostic instruments at two time points (T1 (mean age = 11.2, SD = 3.1) and T2 (mean age = 14.3, SD = 3.6)). Inattention symptoms at T1 were associated with development of psychotic symptoms at T2 (OR:1.2, p = 0.01) but weak associations were found with development of psychotic disorder (OR:1.2, p = 0.15). ADHD diagnosis at T1 was strongly associated with development of psychotic symptoms at T2 (OR:4.5, p