학술논문

Identifying a low‐flow phenotype in heart failure with preserved ejection fraction: a secondary analysis of the RELAX trial
Document Type
article
Source
ESC Heart Failure. 6(4)
Subject
Biomedical and Clinical Sciences
Cardiovascular Medicine and Haematology
Cardiovascular
Heart Disease
Clinical Research
Clinical Trials and Supportive Activities
Aged
Exercise Tolerance
Female
Heart Failure
Humans
Male
Middle Aged
Natriuretic Peptide
Brain
Peptide Fragments
Phenotype
Stroke Volume
Heart failure with preserved ejection fraction
Stroke volume
Fitness
Biomarkers
Cardiorespiratory Medicine and Haematology
Cardiovascular medicine and haematology
Language
Abstract
AimsThe relationship between resting stroke volume (SV) and prognostic markers in heart failure with preserved ejection fraction (HFpEF) is not well established. We evaluated the association of SV index (SVI) at rest with exercise capacity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in stable patients with HFpEF.Methods and resultsParticipants enrolled in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure (RELAX) trial with available data on SVI by the Doppler method were included in this analysis (n = 185). A low-flow state defined by resting SVI